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Atlas / Disease / Ossification of the posterior longitudinal ligament of the spine

Ossification of the posterior longitudinal ligament of the spine

disease
On this page

Also known as OPLLossification of Posterior longitudinal ligamentossification of the POSTERIOR longitudinal ligament of spine

Summary

Ossification of the posterior longitudinal ligament of the spine (MONDO:0011230) is a disease with 11 cohort genes (34 GWAS associations across 4 studies) and 9 clinical trials.

At a glance

  • Cohort genes: 11
  • GWAS associations: 34
  • Clinical trials: 9

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical nameossification of the posterior longitudinal ligament of the spine
Mondo IDMONDO:0011230
EFOEFO:0005895
MeSHC537143
OMIM602475
DOIDDOID:0060887
NCITC84975
SNOMED CT90448008
UMLSC1865343
MedGen355447
GARD0027799
Is cancer (heuristic)no

Also known as: OPLL · ossification of Posterior longitudinal ligament · ossification of the POSTERIOR longitudinal ligament of spine

Data availability: 34 GWAS associations (4 studies) · 6 cell lines.

Disease family

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › ossification of the posterior longitudinal ligament of the spine

Related subtypes (47): symphalangism, cartilage cancer, vertebral column disorder, patellar tendinitis, necrosis of ear ossicle, laryngeal cartilage cancer, ochronosis disorder, chondroma, periodontal disorder, posterior cranial fossa meningioma, anterior cranial fossa meningioma, middle cranial fossa meningioma, bone marrow disorder, cranial nodular fasciitis, flatfoot, bone disorder, skeletal tuberculosis, arthropathy, tooth disorder, primary basilar invagination, Brachymorphism-onychodysplasia-dysphalangism syndrome, cherubism, fibrodysplasia ossificans progressiva, Marfan syndrome, Buschke-Ollendorff syndrome, scalp defects-postaxial polydactyly syndrome, cartilage-hair hypoplasia, Teebi-Shaltout syndrome, short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome, temtamy preaxial brachydactyly syndrome, metaphyseal undermodeling, spondylar dysplasia, and overgrowth, Al-Gazali syndrome, brachydactyly-syndactyly syndrome, endocrine-cerebro-osteodysplasia syndrome, metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria, multiple congenital anomalies-hypotonia-seizures syndrome 3, Rienhoff syndrome, Coffin-Siris syndrome, microcephaly-brachydactyly-kyphoscoliosis syndrome, cartilage development disorder, syndactyly, polydactyly, brachydactyly, sternal neoplasm, short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis, skeletal ligament disorder, brachydactyly-syndactyly-oligodactyly syndrome

Genetics & variants

GWAS landscape

34 GWAS associations across 4 studies. Top hits map to 12 distinct genes (as reported by GWAS).

Top associations by p-value

rsIDp-valueGeneRisk alleleOdds ratio
rs3748101e-15RSPO2 - AURKBP1?0.75
rs61404423e-14SRSF10P2 - HSPBAP1P1?1.39
rs24232941e-13SRSF10P2 - HSPBAP1P1T1.41
rs110495291e-13CCDC91?0.77
rs352810601e-12RNU1-146P - TCP1P3?0.79
rs108414421e-12TCP1P3 - LINC02468?0.78
rs19796794e-12CCDC91T1.3
rs1498697122e-11CAPZA1P1 - CPXCR1?3.48
rs110450003e-11TCP1P3 - LINC02468A1.28
rs132797991e-10LINC00536 - EIF3HG1.28
rs18982872e-10LINC00536 - EIF3H?0.8
rs10386665e-10CCDC91 - FAR2?0.81
rs355052487e-10TMEM135?0.81
rs9274852e-09CDC5L - SUPT3H?0.76
rs46659727e-09SNX17?1.23
rs1912350327e-09MSR1?3.5
rs107706078e-09TCP1P3 - LINC02468?0.74
rs3769893761e-08WWP2?0.79
rs5704418761e-08KAZN?6.9
rs172534811e-08NAB1P1 - Metazoa_SRP?2.62
rs582555982e-08LINC03033 - HIF1A?0.81
rs1896467422e-08AGBL1 - RNU6-185P?2.03
rs2019713012e-08RN7SL547P - SRSF10P2?1.43
rs747074242e-08ZBTB40?2.88
rs5691203012e-08RPL12P42 - CACNA1A?1.96
rs111577333e-08L2HGDH?1.21
rs1826417923e-08RPL29P19 - LINC02947?3.48
rs756605713e-08EMP1?3.23
rs5773950343e-08ZNF85?5.63
rs1389977804e-08SPANXN3 - SLITRK4?2.77

Top studies (by case count)

StudyLead authorYearCasesControlsTitle
GCST90319436Koike Y20232,01020,006Genetic insights into ossification of the posterior longitudinal ligament of the spine.
GCST002545Nakajima M20141,1126,810A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
GCST90319437Koike Y202382014,576Genetic insights into ossification of the posterior longitudinal ligament of the spine.
GCST90319438Koike Y202365120,007Genetic insights into ossification of the posterior longitudinal ligament of the spine.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

TierVariants
Tier 1: coding0
Tier 2: splice/UTR1
Tier 3: regulatory1
Tier 4: intronic/intergenic30

MAF distribution

BucketVariants
common (>=0.05)23
low_freq (0.01-0.05)0
rare (<0.01)0
unknown9

Functional consequences

ConsequenceCount
intron_variant20
intergenic_variant10
regulatory_region_variant1
3_prime_UTR_variant1

Top variants

rsIDChrPosAllelesMAFConsequenceGenep-valueTier
rs3748108108083801G>A0.05intron_variantRSPO2 - AURKBP11e-15Tier 4: intronic/intergenic
rs6140442207848750C>A,T0.05intergenic_variantSRSF10P2 - HSPBAP1P13e-14Tier 4: intronic/intergenic
rs2423294207839121G>A,C0.155intergenic_variantSRSF10P2 - HSPBAP1P11e-13Tier 4: intronic/intergenic
rs110495291228318571C>A,T0.05intron_variantCCDC911e-13Tier 4: intronic/intergenic
rs352810601219823249TG>T,TGG0.05intron_variantRNU1-146P - TCP1P31e-12Tier 4: intronic/intergenic
rs108414421220060666T>A,C0.05intron_variantTCP1P3 - LINC024681e-12Tier 4: intronic/intergenic
rs19796791228253582T>A,C,G0.362intron_variantCCDC914e-12Tier 4: intronic/intergenic
rs149869712X88591778C>Tintron_variantCAPZA1P1 - CPXCR12e-11Tier 4: intronic/intergenic
rs110450001220031212G>A0.46intron_variantTCP1P3 - LINC024683e-11Tier 4: intronic/intergenic
rs132797998116529369T>A,C0.319intergenic_variantLINC00536 - EIF3H1e-10Tier 4: intronic/intergenic
rs18982878116567732A>C,G,T0.05intergenic_variantLINC00536 - EIF3H2e-10Tier 4: intronic/intergenic
rs10386661228932072G>A,C,T0.05intergenic_variantCCDC91 - FAR25e-10Tier 4: intronic/intergenic
rs355052481187119885T>A0.05intron_variantTMEM1357e-10Tier 4: intronic/intergenic
rs927485644570402G>A0.05regulatory_region_variantCDC5L - SUPT3H2e-09Tier 3: regulatory
rs4665972227375230T>C0.05intron_variantSNX177e-09Tier 4: intronic/intergenic
rs191235032816298645T>A,Cintergenic_variantMSR17e-09Tier 4: intronic/intergenic
rs107706071220027307C>T0.05intron_variantTCP1P3 - LINC024688e-09Tier 4: intronic/intergenic
rs3769893761669820427TAG>T0.05intron_variantWWP21e-08Tier 4: intronic/intergenic
rs570441876114938485T>Gintron_variantKAZN1e-08Tier 4: intronic/intergenic
rs17253481X151264532T>G0.05intergenic_variantNAB1P1 - Metazoa_SRP1e-08Tier 4: intronic/intergenic
rs582555981461665087C>T0.05intergenic_variantLINC03033 - HIF1A2e-08Tier 4: intronic/intergenic
rs1896467421587473824G>A0.05intron_variantAGBL1 - RNU6-185P2e-08Tier 4: intronic/intergenic
rs201971301207788066T>A,C0.05intron_variantRN7SL547P - SRSF10P22e-08Tier 4: intronic/intergenic
rs74707424122526921G>A,C,T3_prime_UTR_variantZBTB402e-08Tier 2: splice/UTR
rs5691203011913185065A>Gintron_variantRPL12P42 - CACNA1A2e-08Tier 4: intronic/intergenic
rs111577331450260805G>A,C0.05intron_variantL2HGDH3e-08Tier 4: intronic/intergenic
rs182641792848496518G>A,C,Tintergenic_variantRPL29P19 - LINC029473e-08Tier 4: intronic/intergenic
rs756605711213203470A>Gintron_variantEMP13e-08Tier 4: intronic/intergenic
rs5773950341920933075C>Tintron_variantZNF853e-08Tier 4: intronic/intergenic
rs138997780X143591874C>Tintergenic_variantSPANXN3 - SLITRK44e-08Tier 4: intronic/intergenic

Genes & proteins

Mendelian disease overlap and somatic drivers

GenCC: 0 · Orphanet: 3 · OMIM-shared: 0 · Dual-evidence (GWAS+Mendelian): 0

Orphanet rare-disease linkage (cohort genes)

GeneOrphanet IDRare disease
CCDC91Orphanet:38Acrokeratoelastoidosis of Costa
RSPO2Orphanet:3301Tetraamelia-multiple malformations syndrome
PTHLHOrphanet:93387Brachydactyly type E

Cohort genes → proteins

11 cohort genes, 9 distinct canonical proteins.

Evidence partition

SubsetGenes
gwas_only11

Cohort genes (full)

SymbolHGNCEnsemblUniProtNameEvidence
SUPT3HHGNC:11466ENSG00000196284O75486Transcription initiation protein SPT3 homologgwas
CDC5LHGNC:1743ENSG00000096401Q99459Cell division cycle 5-like proteingwas
CCDC91HGNC:24855ENSG00000123106Q7Z6B0Coiled-coil domain-containing protein 91gwas
RSPO2HGNC:28583ENSG00000147655Q6UXX9R-spondin-2gwas
EMC2HGNC:28963ENSG00000104412Q15006ER membrane protein complex subunit 2gwas
EIF3HHGNC:3273ENSG00000147677O15372Eukaryotic translation initiation factor 3 subunit Hgwas
EIF3EHGNC:3277ENSG00000104408P60228Eukaryotic translation initiation factor 3 subunit Egwas
MIR4642HGNC:41865ENSG00000266619microRNA 4642gwas
LINC00536HGNC:43645ENSG00000249917long intergenic non-protein coding RNA 536gwas
HAO1HGNC:4809ENSG00000101323Q9UJM82-Hydroxyacid oxidase 1gwas
PTHLHHGNC:9607ENSG00000087494P12272Parathyroid hormone-related proteingwas

Cohort function summary

Lead sentence per gene, UniProt-curated.

SymbolProtein nameFunction (lead sentence)
SUPT3HTranscription initiation protein SPT3 homologProbable transcriptional activator.
CDC5LCell division cycle 5-like proteinDNA-binding protein involved in cell cycle control.
CCDC91Coiled-coil domain-containing protein 91Involved in the regulation of membrane traffic through the trans-Golgi network (TGN).
RSPO2R-spondin-2Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors.
EMC2ER membrane protein complex subunit 2Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
EIF3HEukaryotic translation initiation factor 3 subunit HComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.
EIF3EEukaryotic translation initiation factor 3 subunit EComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.
HAO12-Hydroxyacid oxidase 1Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate.
PTHLHParathyroid hormone-related proteinNeuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport.

Protein-family classification

Druggable: 2 · Difficult: 1 · Unknown: 8 · Druggable fraction: 0.18

Family distribution

Cohort families vs a genome-wide background (hypergeometric, BH-FDR; fold = observed/expected). Counts kept; sorted by enrichment, so the catch-all Other/Unknown bucket no longer leads.

FamilyGenesFoldFDR
Protease13.3×0.525
Other/Unknown81.3×0.525
Enzyme (other)11.1×0.758
Transcription factor10.8×0.758

Per-gene assignment

SymbolFamilyDruggable?ECInterPro (top 3)
SUPT3HOther/UnknownnoTFIID_TAF13, Histone-fold
CDC5LTranscription factornoSANT/Myb, Homeodomain-like_sf, Myb_dom
CCDC91Other/UnknownnoCCDC91
RSPO2Other/UnknownnoTSP1_rpt, Furin_repeat, Growth_fac_rcpt_cys_sf
EMC2Other/UnknownnoTPR-like_helical_dom_sf, TPR_rpt, EMC2-like
EIF3HProteaseyesJAMM/MPN+_dom, eIF3h, MPN
EIF3EOther/UnknownnoPCI_dom, eIF3e, eIF3e_N
MIR4642Other/Unknownno
LINC00536Other/Unknownno
HAO1Enzyme (other)yes1.1.3.15FMN-dep_DH, FMN_hydac_DH_AS, Alpha-hydoxy_acid_DH_FMN
PTHLHOther/UnknownnoPTH/PTH-rel, PTH-rel

Expression context

Cohort genes with no expression data: 0.

8 cohort genes are a single-cell marker in ≥1 SCXA experiment.

Breadth distribution (Bgee present_calls)

BucketGenes
narrow (1-5 tissues)0
moderate (6-20)0
broad (>20)11
unknown0

Top tissues across cohort

TissueCohort genes
primordial germ cell in gonad4
male germ line stem cell (sensu Vertebrata) in testis3
calcaneal tendon3
sperm2
buccal mucosa cell1
male germ cell1
left testis1
right testis1
testis1
mucosa of stomach1
oocyte1
secondary oocyte1
C1 segment of cervical spinal cord1
corpus callosum1
cortical plate1
ganglionic eminence1
parietal pleura1
tendon of biceps brachii1
blood1
bone marrow1

Per-gene tissue summary (top 30)

SymbolBgee breadthFANTOM5 breadthSCXATop tissues
SUPT3H206ubiquitousyesprimordial germ cell in gonad, sperm, male germ line stem cell (sensu Vertebrata) in testis
CDC5L290ubiquitousmarkerbuccal mucosa cell, sperm, male germ cell
CCDC91282ubiquitousmarkerleft testis, right testis, testis
RSPO2156broadmarkersecondary oocyte, oocyte, mucosa of stomach
EMC2299ubiquitousmarkercalcaneal tendon, C1 segment of cervical spinal cord, corpus callosum
EIF3H299ubiquitousmarkercortical plate, ganglionic eminence, primordial germ cell in gonad
EIF3E298ubiquitousmarkercalcaneal tendon, tendon of biceps brachii, parietal pleura
MIR464271yesbone marrow, blood, calcaneal tendon
LINC0053642markermale germ line stem cell (sensu Vertebrata) in testis, primordial germ cell in gonad, sural nerve
HAO128tissue_specificyesright lobe of liver, liver, male germ line stem cell (sensu Vertebrata) in testis
PTHLH202broadmarkerperiodontal ligament, primordial germ cell in gonad, stromal cell of endometrium

Protein interactions among cohort

Intra-cohort edges: 4.

Hub genes (top 10 by interactor count)

SymbolInteractor count
CDC5L5,930
EIF3E3,313
EIF3H3,091
HAO12,955
EMC22,213
RSPO22,024
SUPT3H1,603
PTHLH1,599
CCDC911,099
MIR46420

Intra-cohort edges

ABSources
CCDC91HAO1string_interaction
CCDC91RSPO2string_interaction
EIF3EEIF3Hbiogrid_interaction, intact, string_interaction
EIF3ERSPO2string_interaction

Structural data

PDB: 9 · AlphaFold-only: 0 · No structure: 2

Cohort genes with PDB structures (top 30)

SymbolUniProtPDB entries
CDC5LQ9945937
EIF3EP6022828
EIF3HO1537227
HAO1Q9UJM821
EMC2Q1500611
PTHLHP1227211
RSPO2Q6UXX98
SUPT3HO754864
CCDC91Q7Z6B01

Function

Pathway analysis

Distinct Reactome pathways touched by cohort: 22. Enrichment computed across 11 evidence-associated genes (7 with Reactome annotation).

Pathways by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 7 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

PathwayCohort genesFoldFDRSample cohort genes
Formation of the ternary complex, and subsequently, the 43S complex261.6×0.004EIF3H, EIF3E
Translation initiation complex formation254.4×0.004EIF3H, EIF3E
Ribosomal scanning and start codon recognition254.4×0.004EIF3H, EIF3E
Formation of a pool of free 40S subunits232.0×0.007EIF3H, EIF3E
L13a-mediated translational silencing of Ceruloplasmin expression228.9×0.007EIF3H, EIF3E
GTP hydrolysis and joining of the 60S ribosomal subunit228.6×0.007EIF3H, EIF3E
Glyoxylate metabolism and glycine degradation1108.8×0.029HAO1
Regulation of FZD by ubiquitination174.2×0.037RSPO2
Class B/2 (Secretin family receptors)127.2×0.087PTHLH
Peroxisomal protein import124.7×0.087HAO1
TCF dependent signaling in response to WNT116.8×0.105RSPO2
Signaling by WNT116.0×0.105RSPO2
mRNA Splicing115.7×0.105CDC5L
Processing of Capped Intron-Containing Pre-mRNA111.7×0.114CDC5L
Chromatin organization111.7×0.114SUPT3H
HATs acetylate histones111.3×0.114SUPT3H
G alpha (s) signalling events110.5×0.114PTHLH
Chromatin modifying enzymes110.3×0.114SUPT3H
mRNA Splicing - Major Pathway17.8×0.140CDC5L
Dengue Virus-Host Interactions16.5×0.158CDC5L
Metabolism of RNA16.0×0.164CDC5L
Signal Transduction11.4×0.516RSPO2

GO biological processes by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 9 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

GO termCohort genesFoldFDRSample cohort genes
formation of cytoplasmic translation initiation complex2249.7×0.001EIF3H, EIF3E
regulation of translational initiation2104.0×0.004EIF3H, EIF3E
glycine biosynthetic process11872.4×0.005HAO1
glycolate catabolic process11872.4×0.005HAO1
translational initiation279.7×0.005EIF3H, EIF3E
bone mineralization260.4×0.005RSPO2, PTHLH
negative regulation of odontogenesis of dentin-containing tooth1936.2×0.006RSPO2
lung growth1936.2×0.006RSPO2
adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway1936.2×0.006PTHLH
trachea cartilage morphogenesis1624.1×0.008RSPO2
negative regulation of chondrocyte development1624.1×0.008PTHLH
cAMP metabolic process1468.1×0.009PTHLH
fatty acid alpha-oxidation1267.5×0.015HAO1
protein insertion into ER membrane by stop-transfer membrane-anchor sequence1170.2×0.020EMC2
Golgi to lysosome transport1170.2×0.020CCDC91
regulation of chondrocyte differentiation1156.0×0.021PTHLH
osteoblast development1110.1×0.028PTHLH
tail-anchored membrane protein insertion into ER membrane1104.0×0.028EMC2
negative regulation of translational initiation198.5×0.028EIF3E
epithelial tube branching involved in lung morphogenesis193.6×0.028RSPO2
negative regulation of chondrocyte differentiation174.9×0.033PTHLH
dopaminergic neuron differentiation169.3×0.034RSPO2
embryonic hindlimb morphogenesis164.6×0.035RSPO2
embryonic forelimb morphogenesis155.1×0.039RSPO2
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay152.0×0.040EIF3E
limb development145.7×0.042RSPO2
negative regulation of proteasomal ubiquitin-dependent protein catabolic process144.6×0.042EIF3H
DNA damage checkpoint signaling143.5×0.042CDC5L
positive regulation of Wnt signaling pathway142.6×0.042RSPO2
regulation of DNA repair130.7×0.056SUPT3H

Therapeutics

Drug target analysis

Approved (phase 4): 0 · Phase ≥3: 0 · Phased (≥1): 1 · Undrugged: 10

Druggability breadth: 6 of 11 evidence-associated genes (55%) have a ChEMBL target (buckets above are over the deeply-mined display cohort).

Top cohort targets by molecule count

SymbolMoleculesMax phase
EIF3E12
SUPT3H00
CDC5L00
CCDC9100
RSPO200
EMC200
EIF3H00
MIR464200
LINC0053600
HAO100

Drugs targeting cohort genes (top 30)

MoleculeMax phaseTargets in cohort
MOLIBRESIB2EIF3E

Bioactivity and enzyme data

Enzyme cohort genes (≥1 EC): 1.

Cohort genes with ChEMBL bioactivity (full, sorted by assay count)

SymbolAssaysType breakdown
HAO130Binding:30
EIF3E7Binding:7
CDC5L1Binding:1
EMC21Binding:1
EIF3H1Binding:1

Cohort enzymes (BRENDA EC)

SymbolEC numbersNames
HAO11.1.3.15(S)-2-hydroxy-acid oxidase

Pharmacogenomics

Cohort genes with a PharmGKB record: 9; with CPIC/DPWG dosing guidelines: 0.

No cohort gene has a CPIC/DPWG genotype-guided dosing guideline (PharmGKB).

Chemical tractability of cohort targets

1 approved/phased compounds have measured bioactivity against a cohort gene (and aren’t yet in disease-level trials). This is a research / tractability signal, NOT a therapeutic recommendation — a bioactivity row often reflects off-target or screening binding (e.g. promiscuous kinase inhibitors against a cohort kinase), implying no disease mechanism.

CompoundMax phaseCohort target (bioactivity)
MOLIBRESIB2EIF3E

Druggability pyramid

Cohort genes binned by druggability tier (high → low):

TierDefinitionGenesSymbols
AApproved (phase 4 drug)0
BPhased (≥1) drug, not yet approved1EIF3E
CDruggable family + PDB, no drug2EIF3H, HAO1
DDruggable family + AlphaFold only, no drug0
EDifficult family or no structure, no drug8SUPT3H, CDC5L, CCDC91, RSPO2, EMC2, MIR4642, LINC00536, PTHLH

Undrugged target profiles

10 cohort genes are undrugged. Ranked by ‘starting-point quality’ (assay depth + drugged-partner adjacency).

SymbolChEMBL assaysDrugged partners (top 3)
EIF3H1EIF3E
SUPT3H0—
CDC5L1—
CCDC910—
RSPO20—
EMC21—
MIR46420—
LINC005360—
HAO130—
PTHLH0—

Clinical trials & evidence

Clinical trials

Clinical trials: 9.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified8
PHASE41

Top trials by phase / activity

NCTPhaseStatusTitle
NCT01615328PHASE4COMPLETEDEvaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™
NCT04968028Not specifiedACTIVE_NOT_RECRUITINGMulti-centre Study to Evaluate ACAF Versus Laminoplasty in Treating Cervical Ossification of the Posterior Longitudinal Ligament
NCT02926391Not specifiedCOMPLETEDUNiD 3D VBR Register
NCT03312985Not specifiedUNKNOWNComparison of ACAF and ACCF in the Treatment of Cervical OPLL
NCT03591692Not specifiedUNKNOWNA Multi-center Study：Comparison of ACAF and ACCF in the Treatment of Cervical OPLL
NCT04446221Not specifiedCOMPLETEDLong Term Follow-Up of Post Neck Pain Patients Accompanying Ossification of Posterior Longitudinal Ligament Treated With Integrated Complementary and Alternative Medicine: Observational Study
NCT04963101Not specifiedUNKNOWNRNA-seq Analysis of PBMC in Patients With OPLL
NCT05006495Not specifiedCOMPLETEDComparison Between C3-6 Laminoplasty and C3 Laminectomy With Cervical Laminoplasty
NCT06092138Not specifiedCOMPLETEDEdge Computing Platform for Spine Health Risk Management Based on IoT Technology

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

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