Osteochondritis of tarsal/metatarsal bone
diseaseOn this page
Also known as aseptic necrosis of the tarsal bonejuvenile osteochondrosis of footKohler diseaseKohler's diseaseKohler's disease of the tarsal navicularKohler's Osteochondrosis of the tarsal navicularnavicular OsteochondrosisOsteochondrosis of the tarsal bone
Summary
Osteochondritis of tarsal/metatarsal bone (MONDO:0016086) is a disease. A subtype of osteochondrosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide) [Orphanet-validated]
- Phenotypes (HPO): 13
Clinical features
Signs & symptoms
Clinical features (HPO)
13 HPO clinical features (Orphanet curated; top 13 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0008131 | Tarsal stippling | Frequent (30-79%) |
| HP:0008144 | Flattening of the talar dome | Frequent (30-79%) |
| HP:0008369 | Abnormal tarsal ossification | Frequent (30-79%) |
| HP:0010741 | Pedal edema | Frequent (30-79%) |
| HP:0025238 | Foot pain | Frequent (30-79%) |
| HP:0030840 | Ankle pain | Frequent (30-79%) |
| HP:0031051 | Tarsal sclerosis | Frequent (30-79%) |
| HP:0031955 | Antalgic gait | Frequent (30-79%) |
| HP:0100662 | Chondritis | Frequent (30-79%) |
| HP:0001369 | Arthritis | Occasional (5-29%) |
| HP:0010885 | Avascular necrosis | Occasional (5-29%) |
| HP:0010886 | Osteochondritis Dissecans | Occasional (5-29%) |
| HP:0100323 | Juvenile aseptic necrosis | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | osteochondritis of tarsal/metatarsal bone |
| Mondo ID | MONDO:0016086 |
| Orphanet | 563991, 2054 |
| DOID | DOID:11760 |
| SNOMED CT | 203392007 |
| UMLS | C0158444 |
| MedGen | 510539 |
| GARD | 0006842 |
| Is cancer (heuristic) | no |
Also known as: aseptic necrosis of the tarsal bone · juvenile osteochondrosis of foot · Kohler disease · Kohler’s disease · Kohler’s disease of the tarsal navicular · Kohler’s Osteochondrosis of the tarsal navicular · navicular Osteochondrosis · osteochondritis of tarsal/metatarsal bone · Osteochondrosis of the tarsal bone
Disease family
This is a subtype of osteochondrosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › osteonecrosis › osteochondrosis › osteochondritis of tarsal/metatarsal bone
Related subtypes (10): Osgood-Schlatter disease, Legg-Calve-Perthes disease, Thiemann disease, familial form, Scheuermann disease, dihydropyrimidine dehydrogenase deficiency, medial condensing osteitis of the clavicle, Kienbock disease, panner disease, Sinding-Larsen-Johansson disease, Freiberg disease
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.