Osteoid osteoma

Summary

Osteoid osteoma (MONDO:0009808) is a disease and 6 clinical trials. Top therapeutic interventions include zoledronic acid. A subtype of bone benign neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 6

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	osteoid osteoma
Mondo ID	MONDO:0009808
MeSH	D010017
OMIM	259550
NCIT	C3297
SNOMED CT	302859004
UMLS	C0029441
MedGen	18221
GARD	0024697
Is cancer (heuristic)	no

Also known as: osteoid osteoma · osteoid osteoma (disease)

Data availability: 1 HPO phenotype · 3 cell lines.

Disease family

This is a subtype of bone benign neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › musculoskeletal system benign neoplasm › benign connective and soft tissue neoplasm › bone benign neoplasm › osteoid osteoma

Related subtypes (18): bone ameloblastoma, phalanx chondroma, ossifying fibroma, periosteal chondroma, chondroblastoma, osteoma, paranasal sinus Schneiderian papilloma, CHILD syndrome, chondromyxoid fibroma, craniopharyngioma, osteoblastoma, benign neoplasm of pituitary gland, benign neoplasm of sphenoidal sinus, benign neoplasm of frontal sinus, benign neoplasm of maxillary sinus, benign neoplasm of ethmoidal sinus, benign neoplasm of lower jaw bone, desmoplastic fibroma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 6.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3
PHASE3	2
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02923011	PHASE3	RECRUITING	Comparative Effectiveness of MRgFUS Versus CTgRFA for Osteoid Osteomas
NCT02739555	PHASE3	TERMINATED	Zoledronic Acid Compared to Percutaneous Treatment in Osteoid Osteoma
NCT04658771	PHASE2	ACTIVE_NOT_RECRUITING	MR-HIFU Treatment of Painful Osteoid Osteoma
NCT01466010	Not specified	COMPLETED	Treatment Outcome After Surgical Treatment of Osteoid Osteoma
NCT02349971	Not specified	COMPLETED	Safety and Feasibility of MR-Guided High Intensity Focused Ultrasound (MR-HIFU) Ablation of Osteoid Osteoma in Children
NCT02618369	Not specified	COMPLETED	MR-Guided High Intensity Focused Ultrasound for Pain Management Of Osteoid Osteoma & Benign Bone Tumors in Children and Adults

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ZOLEDRONIC ACID	4	1