Osteonecrosis of the jaw

Summary

Osteonecrosis of the jaw (MONDO:0018378) is a disease and 10 clinical trials. A subtype of secondary avascular necrosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 10

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	osteonecrosis of the jaw
Mondo ID	MONDO:0018378
Orphanet	399293
NCIT	C63924
SNOMED CT	441809006
UMLS	C2711248
MedGen	751019
GARD	0021663
Is cancer (heuristic)	no

Also known as: jaw osteonecrosis · ONJ · osteonecrosis of jaw

Disease family

This is a subtype of secondary avascular necrosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › osteonecrosis › avascular necrosis › secondary avascular necrosis › osteonecrosis of the jaw

Related subtypes (5): Gaucher disease type I, hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency, hereditary antithrombin deficiency, traumatic avascular necrosis, secondary non-traumatic avascular necrosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 10.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	9
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02566681	PHASE1	UNKNOWN	Clinical Trial of Use of Autologous Bone Marrow Stem Cells Seeded on Porous Tricalcium Phosphate Matrix and Demineralized Bone Matrix in Patients With Osteonecrosis
NCT05329558	Not specified	ENROLLING_BY_INVITATION	Local and Systemic Changes in Osteonecrosis of the Jawbone
NCT06419010	Not specified	NOT_YET_RECRUITING	Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw
NCT06457776	Not specified	RECRUITING	Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive Drugs
NCT06622421	Not specified	NOT_YET_RECRUITING	Piezoeletric Surgery vs Conventional Surgery for Treatment of MRONJ
NCT07588269	Not specified	NOT_YET_RECRUITING	Bone Quality Evolution in Medication-Related Osteonecrosis of the Jaw Assessed by CBCT (B-ONJ EVOL)
NCT01130389	Not specified	COMPLETED	CONDOR Study of Osteonecrosis of the Jaws (TMJ)
NCT01201330	Not specified	COMPLETED	DPBRN Retrospective Cohort Study of Osteonecrosis of the Jaw
NCT01666106	Not specified	COMPLETED	Osteonecrosis of the Jaw (ONJ) Case Registry
NCT01967160	Not specified	COMPLETED	Osteonecrosis of the Jaw (ONJ) and Infection Among Nordic Cancer Patients Treated With XGEVA™ or Zoledronic Acid