Osteoradionecrosis of the mandible

Summary

Osteoradionecrosis of the mandible (MONDO:0033839) is a disease and 1 clinical trial. A subtype of mouth disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	osteoradionecrosis of the mandible
Mondo ID	MONDO:0033839
Orphanet	521127
ICD-11	677862301
UMLS	C1290728
MedGen	713081
GARD	0022138
Anatomy (UBERON)	UBERON:0001684
Is cancer (heuristic)	no

Disease family

This is a subtype of mouth disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › mouth disorder › osteoradionecrosis of the mandible

Related subtypes (26): uvulitis, adenoid hypertrophy, oral hairy leukoplakia, salivary gland disorder, tongue disorder, alveolar periostitis, lip disorder, oral Crohn disease, maxillary sinusitis, oral candidiasis, oral tuberculosis, Ludwig’s angina, maxillary sinus cholesteatoma, burning mouth syndrome, oral leukoedema, tooth disorder, commissural lip fistula, oral submucous fibrosis, florid cemento-osseous dysplasia, oral cavity neoplasm, neoplasm of floor of mouth, polyp of maxillary sinus, neoplasm of jaw, odontoma, lichen planus, oral, mouth mucosa disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06055257	PHASE3	RECRUITING	Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible