Osteoradionecrosis

Summary

Osteoradionecrosis (MONDO:0043735) is a disease and 14 clinical trials. Top therapeutic interventions include oxygen, pentoxifylline, and alpha-tocopherol. A subtype of osteonecrosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 14

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	osteoradionecrosis
Mondo ID	MONDO:0043735
MeSH	D010025
NCIT	C63707
SNOMED CT	109333005
UMLS	C0029461
MedGen	10500
GARD	0025865
Is cancer (heuristic)	no

Also known as: Osteoradionecroses · osteoradionecrosis

Disease family

This is a subtype of osteonecrosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › osteonecrosis › osteoradionecrosis

Related subtypes (6): Kummell disease, avascular necrosis, osteochondrosis, osteonecrosis of genetic origin, idiopathic phalangeal acro-osteolysis, Dieterich disease

Subtypes (1): osteoradionecrosis of the mandible

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Oxygen.

Clinical trials & evidence

Clinical trials

Clinical trials: 14.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	9
PHASE4	2
PHASE2/PHASE3	1
PHASE3	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04265430	PHASE4	RECRUITING	Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors
NCT02368457	PHASE4	COMPLETED	Management of Mandibular ORN: PENTO as Medical Treatment
NCT06055257	PHASE3	RECRUITING	Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible
NCT00989820	PHASE2/PHASE3	TERMINATED	Efficacy of Hyperbaric Oxygen Therapy in the Treatment of Osteoradionecrosis
NCT00760682	PHASE2	UNKNOWN	Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical Study
NCT02057510	Not specified	ACTIVE_NOT_RECRUITING	Observational Study of Dental Outcomes in Head and Neck Cancer Patients
NCT02661139	Not specified	RECRUITING	Prospective Registry of Prosthodontic Rehabilitation in Oncology Patients Undergoing Jaw Reconstruction
NCT05325970	Not specified	ACTIVE_NOT_RECRUITING	Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients
NCT05412849	Not specified	RECRUITING	Radiation Field, Dose and Fractionation Related to Mandibular Complications
NCT01147315	Not specified	COMPLETED	ORN Study: Curative Treatment of Osteoradionecrosis (ORN) With Hybrid Bone Substitution
NCT04009161	Not specified	UNKNOWN	Osteoradionecrosis Rate in Patients Undergoing Radiotherapy for Head and Neck Cancer Treatment.
NCT04717765	Not specified	COMPLETED	Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention
NCT04934644	Not specified	UNKNOWN	The Effect of Hyperbaric Oxygen Treatment in Patients With Osteoradionecrosis.
NCT06428994	Not specified	COMPLETED	Risk for Subsequent Osteoradionecrosis in A Transferred Fibula Flap in Head and Neck Cancer Patients Undergoing Segmental Mandibulectomy: a Cohort Study

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
OXYGEN	4	1
PENTOXIFYLLINE	4	1
ALPHA-TOCOPHEROL	0	1