Otitis media with effusion
diseaseOn this page
Also known as OMEsecretory otitis Mediaserous otitis Media
Summary
Otitis media with effusion (MONDO:0005892) is a disease and 51 clinical trials. Top therapeutic interventions include lansoprazole, streptococcus pneumoniae polysaccharide conjugated to corynebacterium diphtheriae crm197, and mometasone. A subtype of chronic non-suppurative otitis media — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 51
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | otitis media with effusion |
| Mondo ID | MONDO:0005892 |
| EFO | EFO:0007415 |
| MeSH | D010034 |
| NCIT | C34886 |
| SNOMED CT | 78868004 |
| UMLS | C0456498 |
| MedGen | 629314 |
| Is cancer (heuristic) | no |
Also known as: OME · secretory otitis Media · serous otitis Media
Disease family
This is a subtype of chronic non-suppurative otitis media. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › auditory system disorder › middle ear disorder › otitis media › non-suppurative otitis media › chronic non-suppurative otitis media › otitis media with effusion
Related subtypes (1): serous glue ear
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 3 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Mometasone | Phase 3 (in late-stage trials) |
| Sodium Chloride | Phase 3 (in late-stage trials) |
| Triamcinolone Acetonide | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Xylitol.
Clinical trials & evidence
Clinical trials
Clinical trials: 51.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 39 |
| PHASE3 | 6 |
| PHASE4 | 2 |
| PHASE2/PHASE3 | 2 |
| PHASE2 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01082029 | PHASE4 | COMPLETED | Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children |
| NCT03590912 | PHASE4 | COMPLETED | Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With Effusion |
| NCT07189572 | PHASE3 | NOT_YET_RECRUITING | Intranasal Corticosteroid Spray for Preventing Otitis Media With Effusion After Radiotherapy in Nasopharyngeal Carcinoma |
| NCT00016497 | PHASE3 | TERMINATED | Adenoidectomy for Otitis Media in 2-3 Year Old Children |
| NCT00279916 | PHASE3 | COMPLETED | Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays |
| NCT01202578 | PHASE2/PHASE3 | COMPLETED | Evaluation of the Tympanostomy Tube Delivery System |
| NCT01949142 | PHASE3 | COMPLETED | OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement |
| NCT01949155 | PHASE3 | COMPLETED | OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement |
| NCT02858388 | PHASE3 | COMPLETED | Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media |
| NCT02950311 | PHASE2/PHASE3 | WITHDRAWN | Xylitol for Otitis Media |
| NCT00629694 | PHASE2 | COMPLETED | Adenoidectomy, Myringotomy and Tubes’ Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy |
| NCT03491098 | EARLY_PHASE1 | UNKNOWN | The Efficacy of Nasal Steroids in Treatment of Otitis Media With Effusion: Acomparative Study |
| NCT05353569 | Not specified | RECRUITING | Coherent Optical Detection of Middle Ear Disease |
| NCT05535634 | Not specified | RECRUITING | Sound Ear Check (SEC) in Hearing Diagnostics in Young Children |
| NCT05915078 | Not specified | RECRUITING | Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry |
| NCT06191562 | Not specified | ACTIVE_NOT_RECRUITING | Posterior vs. Anterior Tympanostomy Tube Placement |
| NCT06838403 | Not specified | RECRUITING | Effect of Masgutova Neurosensorimotor Reflex Integration on Oro-Motor Functional Skills in Children With Cerebral |
| NCT07242001 | Not specified | RECRUITING | Laser Acupuncture for Otitis Media With Effusion in Children |
| NCT00195611 | Not specified | COMPLETED | Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media |
| NCT00393900 | Not specified | COMPLETED | Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion |
| NCT00520039 | Not specified | COMPLETED | Osteopathic Otitis Media Research Study |
| NCT00546117 | Not specified | COMPLETED | A Clinical Trial of Proton Pump Inhibitors to Treat Children With Chronic Otitis Media With Effusion |
| NCT00547326 | Not specified | WITHDRAWN | The Effect of Osteopatic Cranial Techniques on the Audiometric and Tympanometric Values in Children Suffering From Otitis Media With Effusion. |
| NCT00736112 | Not specified | WITHDRAWN | Food Allergy - Tubes - Adenoids (FATA) Trial |
| NCT00939796 | Not specified | COMPLETED | Clinical Study of the Tympanostomy Tube Delivery System |
| NCT01421199 | Not specified | UNKNOWN | Device Study to Evaluate the Detection and Characterization of Middle Ear Fluid in Children |
| NCT01967498 | Not specified | UNKNOWN | Montelukast for Children With Chronic Otitis Media With Effusion (COME): A Double-blind, Placebo-controlled Study |
| NCT02019888 | Not specified | COMPLETED | Wide Frequency Band Test of Hearing in Veterans |
| NCT02179541 | Not specified | COMPLETED | A Novel Objective Diagnostic Test for Otitis Media With Effusion |
| NCT02183961 | Not specified | COMPLETED | Three Methods Used in the Diagnosis of EER in Children With OME |
| NCT02183974 | Not specified | COMPLETED | Suitable Method for Routine Diagnostics of EER in Children With Otitis Media With Effusion |
| NCT02215681 | Not specified | UNKNOWN | Acupuncture Effect on Inflammatory Markers in Pediatric Otitis Media With Effusion: A Pilot Study |
| NCT02282540 | Not specified | COMPLETED | Novel Imaging of the Eustachian Tube; Patient Study |
| NCT02409693 | Not specified | WITHDRAWN | Retrospective Analysis of Perioperative Anesthetic Care and Analgesia Management of Patient Undergoing Bilateral Myringotomy With Tube Insertion |
| NCT02477735 | Not specified | UNKNOWN | The Effect of Tympanostomy Tube Insertion on Sleep in Children With Chronic Otitis Media With Effusion |
| NCT02546518 | Not specified | UNKNOWN | A Comparison of Surgical and a New Non-Surgical Treatment Methods for Secretory Otitis Media in Children |
| NCT02549612 | Not specified | UNKNOWN | The Effect of Early Non-Surgical Treatment of Children With Middle Ear Effusion on the Hearing |
| NCT02716376 | Not specified | COMPLETED | Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy |
| NCT03109496 | Not specified | COMPLETED | The URT and Middle Ear Microbiota in Health and During Chronic OME |
| NCT03277820 | Not specified | COMPLETED | Effect of Probiotics on Nasopharyngeal Microbiome of Children With Otitis Media With Effusion |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LANSOPRAZOLE | 4 | 2 |
| STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE CONJUGATED TO CORYNEBACTERIUM DIPHTHERIAE CRM197 | 4 | 1 |
| MOMETASONE | 3 | 1 |