Ovarian mixed germ cell neoplasm
disease diseaseOn this page
Also known as mixed germ cell neoplasm of ovarymixed germ cell neoplasm of the ovarymixed germ cell tumormixed germ cell tumor of ovarymixed germ cell tumor of the ovarymixed germ cell tumourmixed germ cell tumour of ovarymixed germ cell tumour of the ovaryovarian mixed germ cell tumorovarian mixed germ cell tumourovary mixed germ cell tumorovary mixed germ cell tumour
Summary
Ovarian mixed germ cell neoplasm (MONDO:0003710) is a cancer and 7 clinical trials. Top therapeutic interventions include ifosfamide and etoposide phosphate. A subtype of ovarian primitive germ cell tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 7
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | ovarian mixed germ cell neoplasm |
| Mondo ID | MONDO:0003710 |
| DOID | DOID:5936 |
| NCIT | C8114 |
| UMLS | C0280135 |
| MedGen | 83602 |
| GARD | 0023629 |
| Anatomy (UBERON) | UBERON:0000992 |
| Is cancer (heuristic) | yes |
Also known as: mixed germ cell neoplasm of ovary · mixed germ cell neoplasm of the ovary · mixed germ cell tumor · mixed germ cell tumor of ovary · mixed germ cell tumor of the ovary · mixed germ cell tumour · mixed germ cell tumour of ovary · mixed germ cell tumour of the ovary · ovarian mixed germ cell neoplasm · ovarian mixed germ cell tumor · ovarian mixed germ cell tumour · ovary mixed germ cell tumor · ovary mixed germ cell tumour
Data availability: 8 cell lines · 10 intOGen driver records.
Disease family
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › malignant germ cell tumor › malignant germ cell tumor of ovary › ovarian primitive germ cell tumor › ovarian mixed germ cell neoplasm
Related subtypes (3): dysgerminoma of ovary, non-gestational ovarian choriocarcinoma, malignant non-dysgerminomatous germ cell tumor of ovary
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 7.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 3 |
| PHASE1 | 2 |
| PHASE3 | 1 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02375204 | PHASE3 | ACTIVE_NOT_RECRUITING | Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors |
| NCT04684368 | PHASE2 | RECRUITING | A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT |
| NCT00060372 | PHASE1 | COMPLETED | Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer |
| NCT00638898 | PHASE1 | COMPLETED | Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor |
| NCT05564026 | Not specified | RECRUITING | Molecular Epidemiology of Pediatric Germ Cell Tumors |
| NCT01080521 | Not specified | COMPLETED | Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy |
| NCT01434355 | Not specified | COMPLETED | DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| IFOSFAMIDE | 4 | 2 |
| ETOPOSIDE PHOSPHATE | 4 | 1 |
Related Atlas pages
- Drugs: Ifosfamide, Etoposide Phosphate