Overlap myositis
diseaseOn this page
Also known as adult-onset overlap myositisnon-specific myositis
Summary
Overlap myositis (MONDO:0016099) is a disease and 1 clinical trial. Top therapeutic interventions include abatacept. A subtype of acquired idiopathic inflammatory myopathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Europe)
- Phenotypes (HPO): 40
- Clinical trials: 1
Clinical features
Signs & symptoms
Clinical features (HPO)
40 HPO clinical features (Orphanet curated; top 40 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000822 | Hypertension | Frequent (30-79%) |
| HP:0001369 | Arthritis | Frequent (30-79%) |
| HP:0002015 | Dysphagia | Frequent (30-79%) |
| HP:0002960 | Autoimmunity | Frequent (30-79%) |
| HP:0003119 | Abnormal circulating lipid concentration | Frequent (30-79%) |
| HP:0003236 | Elevated circulating creatine kinase concentration | Frequent (30-79%) |
| HP:0003493 | Antinuclear antibody positivity | Frequent (30-79%) |
| HP:0003701 | Proximal muscle weakness | Frequent (30-79%) |
| HP:0008997 | Proximal muscle weakness in upper limbs | Frequent (30-79%) |
| HP:0011838 | Sclerodactyly | Frequent (30-79%) |
| HP:0025131 | Finger swelling | Frequent (30-79%) |
| HP:0025142 | Constitutional symptom | Frequent (30-79%) |
| HP:0030859 | Anti-topoisomerase I antibody positivity | Frequent (30-79%) |
| HP:0030880 | Raynaud phenomenon | Frequent (30-79%) |
| HP:0032169 | Severe infection | Frequent (30-79%) |
| HP:0033040 | Anti-Sm antibody positivity | Frequent (30-79%) |
| HP:0033555 | Anti-Ro/SS-A antibody positivity | Frequent (30-79%) |
| HP:0033560 | Anti-PM-Scl antibody positivity | Frequent (30-79%) |
| HP:0034088 | Anti-Ku antibody positivity | Frequent (30-79%) |
| HP:0034093 | Anti-Ro52/TRIM21 antibody positivity | Frequent (30-79%) |
| HP:0100296 | Perifascicular muscle fiber atrophy | Frequent (30-79%) |
| HP:0000077 | Abnormality of the kidney | Occasional (5-29%) |
| HP:0000819 | Diabetes mellitus | Occasional (5-29%) |
| HP:0001288 | Gait disturbance | Occasional (5-29%) |
| HP:0001627 | Abnormal heart morphology | Occasional (5-29%) |
| HP:0001873 | Thrombocytopenia | Occasional (5-29%) |
| HP:0001882 | Leukopenia | Occasional (5-29%) |
| HP:0002092 | Pulmonary arterial hypertension | Occasional (5-29%) |
| HP:0002273 | Tetraparesis | Occasional (5-29%) |
| HP:0002725 | Systemic lupus erythematosus | Occasional (5-29%) |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | Occasional (5-29%) |
| HP:0003549 | Abnormality of connective tissue | Occasional (5-29%) |
| HP:0003551 | Difficulty climbing stairs | Occasional (5-29%) |
| HP:0004269 | Subluxation of the small joints of the hand | Occasional (5-29%) |
| HP:0006530 | Abnormal pulmonary interstitial morphology | Occasional (5-29%) |
| HP:0009053 | Distal lower limb muscle weakness | Occasional (5-29%) |
| HP:0009763 | Limb pain | Occasional (5-29%) |
| HP:0011121 | Abnormal skin morphology | Occasional (5-29%) |
| HP:0100324 | Scleroderma | Occasional (5-29%) |
| HP:0001370 | Rheumatoid arthritis | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | overlap myositis |
| Mondo ID | MONDO:0016099 |
| Orphanet | 206572 |
| UMLS | C5679784 |
| MedGen | 1814440 |
| GARD | 0020352 |
| Is cancer (heuristic) | no |
Also known as: adult-onset overlap myositis · non-specific myositis
Disease family
This is a subtype of acquired idiopathic inflammatory myopathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › muscle tissue disorder › skeletal muscle disorder › acquired skeletal muscle disease › acquired idiopathic inflammatory myopathy › overlap myositis
Related subtypes (8): eosinophilic fasciitis, immune-mediated necrotizing myopathy, inflammatory myopathy with abundant macrophages, idiopathic eosinophilic myositis, juvenile idiopathic inflammatory myopathy, focal myositis, polymyositis, antisynthetase syndrome
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 1.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02971683 | PHASE3 | COMPLETED | Trial to Evaluate the Efficacy and Safety of Abatacept in Combination With Standard Therapy Compared to Standard Therapy Alone in Improving Disease Activity in Adults With Active Idiopathic Inflammatory Myopathy |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ABATACEPT | 4 | 1 |
Related Atlas pages
- Drugs: Abatacept