Pandas

Summary

PANDAS (MONDO:0019020) is a disease and 11 clinical trials. Top therapeutic interventions include human immunoglobulin g and naproxen sodium. A subtype of pediatric acute-onset neuropsychiatric syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 24
• Clinical trials: 11

Clinical features

Signs & symptoms

Clinical features (HPO)

24 HPO clinical features (Orphanet curated; top 24 by frequency):

HPO ID	Term	Frequency
HP:0100033	Tics	Very frequent (80-99%)
HP:0000712	Emotional lability	Frequent (30-79%)
HP:0000716	Depression	Frequent (30-79%)
HP:0000737	Irritability	Frequent (30-79%)
HP:0000751	Personality changes	Frequent (30-79%)
HP:0002072	Chorea	Frequent (30-79%)
HP:0002360	Sleep abnormality	Frequent (30-79%)
HP:0002376	Developmental regression	Frequent (30-79%)
HP:0007018	Attention deficit hyperactivity disorder	Frequent (30-79%)
HP:0008770	Obsessive-compulsive trait	Frequent (30-79%)
HP:0010865	Oppositional defiant disorder	Frequent (30-79%)
HP:0100710	Impulsivity	Frequent (30-79%)
HP:0100852	Abnormal fear/anxiety-related behavior	Frequent (30-79%)
HP:0000756	Agoraphobia	Occasional (5-29%)
HP:0000805	Enuresis	Occasional (5-29%)
HP:0002039	Anorexia	Occasional (5-29%)
HP:0002183	Phonophobia	Occasional (5-29%)
HP:0002312	Clumsiness	Occasional (5-29%)
HP:0002829	Arthralgia	Occasional (5-29%)
HP:0005366	Recurrent streptococcus pneumoniae infections	Occasional (5-29%)
HP:0025253	Claustrophobia	Occasional (5-29%)
HP:0031468	Separation insecurity	Occasional (5-29%)
HP:0040183	Encopresis	Occasional (5-29%)
HP:0100754	Mania	Excluded (0%)

Identifiers

Disease identifiers

Field	Value
Canonical name	PANDAS
Mondo ID	MONDO:0019020
MeSH	C537163
Orphanet	66624
UMLS	C2931429
MedGen	419798
GARD	0007312
Is cancer (heuristic)	no

Also known as: paediatric autoimmune disorders associated with Streptococcus infections · paediatric autoimmune neuropsychiatric disorder associated with Streptococcus · paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections · paediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections · pediatric autoimmune disorders associated with Streptococcus infections · pediatric autoimmune neuropsychiatric disorder associated with Streptococcus · pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections · pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections

Disease family

Classification path: disease › human disease › disease by body system or component › nervous system disorder › autoimmune disorder of the nervous system › pediatric acute-onset neuropsychiatric syndrome › PANDAS

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE4	2
PHASE2	2
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03348618	PHASE4	UNKNOWN	A Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
NCT04015596	PHASE4	TERMINATED	Trial of Naproxen Sodium for the Treatment of OCD in Children With PANDAS
NCT01281969	PHASE3	COMPLETED	Intravenous Immunoglobulin for PANDAS
NCT01617083	PHASE2	COMPLETED	Antibiotic Treatment Trial for the PANDAS/PANS Phenotype
NCT01769027	PHASE2	WITHDRAWN	Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS
NCT02889016	Not specified	RECRUITING	Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS
NCT04806620	Not specified	RECRUITING	Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
NCT06811935	Not specified	RECRUITING	PEDI Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcus Study
NCT02190292	Not specified	COMPLETED	PANS - A Detailed Study of the Patients, Their Symptoms, Biomarkers and Treatment Offered in a Scandinavian Cohort
NCT04382716	Not specified	COMPLETED	Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Clinical Characterization and Prospective Course
NCT06818656	Not specified	COMPLETED	The Unhide™ Project: Economic Impact Study of IVIG Treatment for PANS

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
HUMAN IMMUNOGLOBULIN G	4	1
NAPROXEN SODIUM	4	1
CHEMBL4299381	0	1