Panniculitis and localized lipodystrophy

Summary

Panniculitis and localized lipodystrophy (MONDO:0019555) is a disease. A subtype of panniculitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 9

Clinical features

Signs & symptoms

Clinical features (HPO)

9 HPO clinical features (Orphanet curated; top 9 by frequency):

HPO ID	Term	Frequency
HP:0100578	Lipoatrophy	Obligate (100%)
HP:0003758	Reduced subcutaneous adipose tissue	Very frequent (80-99%)
HP:0007485	Absence of subcutaneous fat	Frequent (30-79%)
HP:0010701	Abnormal immunoglobulin level	Frequent (30-79%)
HP:0010783	Erythema	Frequent (30-79%)
HP:0011123	Inflammatory abnormality of the skin	Frequent (30-79%)
HP:0200036	Skin nodule	Frequent (30-79%)
HP:0003493	Antinuclear antibody positivity	Occasional (5-29%)
HP:0200029	Vasculitis in the skin	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	panniculitis and localized lipodystrophy
Mondo ID	MONDO:0019555
Orphanet	90159
UMLS	C5190785
MedGen	1678538
GARD	0019128
Is cancer (heuristic)	no

Also known as: panniculitis-induced localised lipodystrophy

Disease family

This is a subtype of panniculitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › integumentary system disorder › panniculitis › panniculitis and localized lipodystrophy

Related subtypes (5): nodular non-suppurative panniculitis, lupus erythematosus panniculitis, cytophagic histiocytic panniculitis, lipodermatosclerosis, erythema nodosum

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.