Papilloma

Summary

Papilloma (MONDO:0002363) is a disease (an umbrella term covering 14 Mondo subtypes) and 10 clinical trials. Top therapeutic interventions include cidofovir anhydrous, bevacizumab, and arundine. A subtype of papillary epithelial neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 14 Mondo subtypes
• Clinical trials: 10

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	papilloma
Mondo ID	MONDO:0002363
MeSH	D010212
DOID	DOID:2615
NCIT	C7440
SNOMED CT	711329002
UMLS	C0030354
MedGen	10566
Is cancer (heuristic)	no

Also known as: papilloma · papilloma (except papilloma of bladder M-81201) (morphologic abnormality) · papilloma, benign

Disease family

An umbrella term covering 14 Mondo subtypes.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › papillary epithelial neoplasm › papilloma

Related subtypes (8): gallbladder papillary neoplasm, papillary adenoma, papillary urothelial neoplasm, ovarian papillary tumor, endolymphatic sac tumor, papillary cystic neoplasm, papillary carcinoma, papillomatosis

Subtypes (14): squamous papilloma, intraductal papilloma, serous surface papilloma, fallopian tube papilloma, verrucous papilloma, skin papilloma, inverted papilloma, cervical mullerian papilloma, transitional cell papilloma, lung papilloma, choroid plexus papilloma, glandular papilloma, papilloma of buccal mucosa, laryngeal papillomatosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Bevacizumab, Celecoxib, Pembrolizumab, Propranolol.

Clinical trials & evidence

Clinical trials

Clinical trials: 10.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	7
PHASE2	2
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05797246	PHASE2	ACTIVE_NOT_RECRUITING	Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP)
NCT00038714	PHASE2	COMPLETED	A Trial Study of SGN-00101 in Treating Pediatric Patients With Recurrent Respiratory Papillomatosis
NCT00001126	PHASE1	COMPLETED	Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)
NCT00001603	Not specified	COMPLETED	The Effects of Upper Airway and Digestive Tract Tumors on the Immune System
NCT00006444	Not specified	COMPLETED	The Effects of Combination Anti-HIV Medication on Human Papillomavirus (HPV) in HIV-Infected Women
NCT00591305	Not specified	TERMINATED	New Therapy of Laryngeal Papilloma In Children
NCT01175499	Not specified	WITHDRAWN	Concordance of Two Endoscopic Procedures for Diagnosis of Carcinoma of the Upper Aerodigestive Tract
NCT01234480	Not specified	TERMINATED	Intended Use Study of the BD SurePath Plus™ Pap
NCT01827423	Not specified	COMPLETED	Squamous Cell Carcinoma Antigen Analysis at the University Hospital Ostrava
NCT05625308	Not specified	COMPLETED	Effect of Natural Compounds on the Severity of HPV-induced Cervical Lesions

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CIDOFOVIR ANHYDROUS	4	2
BEVACIZUMAB	4	1
ARUNDINE	3	1