Paraphilic disorder

Summary

Paraphilic disorder (MONDO:0000596) is a disease (an umbrella term covering 5 Mondo subtypes) and 7 clinical trials. A subtype of psychosexual disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 5 Mondo subtypes
• Clinical trials: 7

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	paraphilic disorder
Mondo ID	MONDO:0000596
MeSH	D010262
DOID	DOID:0060044
SNOMED CT	50299009
UMLS	C0030482
MedGen	18299
Is cancer (heuristic)	no

Also known as: deviation, Sex · Deviations, Sex · disorder of sexual preference · disorder, Paraphilic · disorders, Paraphilic · paraphilia · Paraphilias · paraphilic disorder · Sex deviation · Sex Deviations

Disease family

This is a subtype of psychosexual disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › sexual disorder › psychosexual disorder › paraphilic disorder

Related subtypes (4): psychologic vaginismus, psychologic dyspareunia, hypoactive sexual desire disorder, orgasm disorder

Subtypes (5): exhibitionism, voyeurism, fetishistic disorder, pedophilia, zoophilia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 7.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00379626	PHASE1	TERMINATED	Cognitive and Hormonal Treatment of Sex Offenders
NCT05861752	Not specified	RECRUITING	Paraphilic Disorders and Other Conditions With Risk for Sexual Violence: a Case-control Study
NCT06404684	Not specified	RECRUITING	Psychological Treatment for Paraphilic Disorders
NCT01743209	Not specified	COMPLETED	Descriptive Epidemiology Study for Patients With Paraphilia Sex Offenders and Receiving Androgen Antagonists
NCT04316650	Not specified	WITHDRAWN	Study of Maintenance of the Efficiency and Adverse Effects of Pharmacological Treatments in Sex Offenders With Paraphilia
NCT05482412	Not specified	UNKNOWN	Acute Intense Paraphilic Desire (DSM-V) Down-Regulation Via taVNS Neuro-Modulation [Transcutaneous Afferent Vagus Nerve] With Future Operative Implant Consideration
NCT05628402	Not specified	UNKNOWN	Exhibitionnists’s Cognitive Mecanisms

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CHEMBL454299	0	1