parkinsonism with dementia of Guadeloupe

Summary

parkinsonism with dementia of Guadeloupe (MONDO:0019977) is a disease. A subtype of dementia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 27

Clinical features

Signs & symptoms

Clinical features (HPO)

27 HPO clinical features (Orphanet curated; top 27 by frequency):

HPO ID	Term	Frequency
HP:0001300	Parkinsonism	Very frequent (80-99%)
HP:0002063	Rigidity	Very frequent (80-99%)
HP:0002067	Bradykinesia	Very frequent (80-99%)
HP:0000511	Vertical supranuclear gaze palsy	Frequent (30-79%)
HP:0000571	Hypometric saccades	Frequent (30-79%)
HP:0000726	Dementia	Frequent (30-79%)
HP:0000727	Frontal lobe dementia	Frequent (30-79%)
HP:0000738	Hallucinations	Frequent (30-79%)
HP:0001278	Orthostatic hypotension	Frequent (30-79%)
HP:0001332	Dystonia	Frequent (30-79%)
HP:0001336	Myoclonus	Frequent (30-79%)
HP:0002119	Ventriculomegaly	Frequent (30-79%)
HP:0002120	Cerebral cortical atrophy	Frequent (30-79%)
HP:0002172	Postural instability	Frequent (30-79%)
HP:0002186	Apraxia	Frequent (30-79%)
HP:0002193	Pseudobulbar behavioral symptoms	Frequent (30-79%)
HP:0002345	Action tremor	Frequent (30-79%)
HP:0002360	Sleep abnormality	Frequent (30-79%)
HP:0003458	EMG: myopathic abnormalities	Frequent (30-79%)
HP:0005341	Autonomic bladder dysfunction	Frequent (30-79%)
HP:0007045	Midline brain calcifications	Frequent (30-79%)
HP:0007240	Progressive gait ataxia	Frequent (30-79%)
HP:0010549	Weakness due to upper motor neuron dysfunction	Frequent (30-79%)
HP:0012332	Abnormal autonomic nervous system physiology	Frequent (30-79%)
HP:0012753	T2 hypointense basal ganglia	Frequent (30-79%)
HP:0030902	Palmomental reflex	Frequent (30-79%)
HP:0100315	Lewy bodies	Excluded (0%)

Identifiers

Disease identifiers

Field	Value
Canonical name	parkinsonism with dementia of Guadeloupe
Mondo ID	MONDO:0019977
Orphanet	97355
ICD-11	773801248
SNOMED CT	715737004
UMLS	C4275027
MedGen	899794
GARD	0019372
Is cancer (heuristic)	no

Disease family

This is a subtype of dementia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › cognitive disorder › dementia › parkinsonism with dementia of Guadeloupe

Related subtypes (8): vascular dementia, Alzheimer disease, Lewy body dementia, hereditary dementia, dementia pugilistica, AIDS dementia complex, progressive dementia with neuroserpin inclusion bodies, childhood-onset dementia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.