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Atlas / Disease / Patellofemoral pain syndrome

Patellofemoral pain syndrome

disease
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Summary

Patellofemoral pain syndrome (MONDO:0006894) is a disease and 185 clinical trials. Top therapeutic interventions include hylan g-f 20. A subtype of arthropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 185

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namepatellofemoral pain syndrome
Mondo IDMONDO:0006894
EFOEFO:1001092
MeSHD046788
DOIDDOID:14284
SNOMED CT430725003
UMLSC0877149
MedGen164080
MedDRA10049143
Anatomy (UBERON)UBERON:0011166
Is cancer (heuristic)no

Disease family

This is a subtype of arthropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › arthropathy › patellofemoral pain syndrome

Related subtypes (23): transient arthropathy, synovial plica syndrome, hypermobility syndrome, Tietze syndrome, neurogenic arthropathy, Behcet syndrome arthropathy, ankylosis, bursitis, synovium neoplasm, hydrarthrosis, articular cartilage disorder, hemarthrosis, tenosynovitis, ganglion or cyst of synovium/tendon/bursa, spondyloarthropathy, temporomandibular joint disorder, arthritic joint disease, de Quervain disease, frozen shoulder, secondary hypertrophic osteoarthropathy, shoulder impingement syndrome, crystal arthropathy, vertebral joint disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

DrugDevelopment status
OnabotulinumtoxinaPhase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): HYLAN G-F 20.

Clinical trials & evidence

Clinical trials

Clinical trials: 185.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified173
PHASE1/PHASE25
PHASE34
PHASE21
PHASE11
EARLY_PHASE11

Top trials by phase / activity

NCTPhaseStatusTitle
NCT03184545PHASE3RECRUITINGComparing the Outcome of Electrical Stimulation and Physical Therapy in Patellofemoral Pain Syndrome
NCT00118521PHASE3COMPLETEDA Clinical Study in the Use of Orthotics in Treating Pain in the Front of the Knee
NCT00496964PHASE3TERMINATEDBotox for Non-surgical Lateral Release in Patellofemoral Pain
NCT02379364PHASE3COMPLETEDDiacutaneous Fibrolysis and Patellofemoral Pain Syndrome
NCT00451347PHASE1/PHASE2UNKNOWNComparison of The Clinical Effects Between Different Physical Therapy Tools in Patellofemoral Pain Patients
NCT01332110PHASE1/PHASE2COMPLETEDTreatment for Patellofemoral Pain Syndrome Using Footwear
NCT01691170PHASE1/PHASE2COMPLETEDComparison of Two Protocols for Patellofemoral Pain Syndrome
NCT02613247PHASE2UNKNOWNIntra-articular Hyaluronic Acid Injection for Therapy-resistant Patellofemoral Pain Syndrome
NCT02810002PHASE1/PHASE2COMPLETEDAssessing Foot Injuries in Infantry Recruits Wearing Different Boots
NCT06439251PHASE1/PHASE2COMPLETEDEffects of Mulligan Technique With or Without Diclofenac Phonophoresis on Patellofemoral Pain Syndrome.
NCT00451087PHASE1UNKNOWNComparisons of Mechanical Properties of Tendon Structures
NCT02854774EARLY_PHASE1TERMINATEDNeural Mechanisms of Muscle Control in Individuals With Knee Pain
NCT00051857Not specifiedRECRUITINGMRI Study of Musculoskeletal Function
NCT02890485Not specifiedRECRUITINGThe Effects of Dry Needling on Patients With Knee Pain
NCT04631614Not specifiedNOT_YET_RECRUITINGAddition Effect of the Ankle Manual Therapy to Muscle Strengthening Exercise in Women With Patellofemoral Pain
NCT05561153Not specifiedENROLLING_BY_INVITATIONCentral Neuromuscular Dysfunction in Patellofemoral Pain
NCT06257862Not specifiedACTIVE_NOT_RECRUITINGTranslation, Cross-cultural Validity and Reliability of a Danish Version of the Anterior Knee Pain Scale
NCT06260865Not specifiedACTIVE_NOT_RECRUITINGA Confirmatory Trial of Multidisciplinary Digital Therapeutics for Patellofemoral Pain Syndrome
NCT06387524Not specifiedRECRUITINGEffects of Eccentric Exercises on Gait Parameters in Patellofemoral Pain Syndrome: A Quasi-Experimental Study
NCT06502795Not specifiedRECRUITINGQuadriceps Strengthening At Different Angles in Patellofemoral Pain
NCT06511362Not specifiedRECRUITINGComparative Effects of Perturbation and Functional Stabilization Training on Patellofemoral Pain Syndrome
NCT06517056Not specifiedRECRUITINGEmovi 3D Knee Assessment Device Intervention for Operational Readiness
NCT06565520Not specifiedRECRUITINGModulating Cortical Excitability to Improve Functional Movements in Individuals With Patellofemoral Pain
NCT06566950Not specifiedRECRUITINGBFR Training on Muscle Morphology
NCT06598618Not specifiedRECRUITINGComparison of IASTM and Muscle Energy Technique in Patellofemoral Pain Syndrome.
NCT06674707Not specifiedRECRUITINGEffects of Agility Training With and Without Foot Mobilization In Patellofemoral Pain Syndrome.
NCT06736756Not specifiedRECRUITINGImpact of Tensor Fascia Lata Stretch on Vastus Medialis Obliqus Activity
NCT06757959Not specifiedACTIVE_NOT_RECRUITINGEffectiveness of Wet Needling Technique in Patients of Patellofemoral Pain Syndrome
NCT06758050Not specifiedRECRUITINGEffect of Core Exercises on Patellofemoral Pain Syndrome
NCT06875804Not specifiedRECRUITINGCompressive Myofascial Release of the Vastus Lateralis on Lateral Patellar Tracking in Patellofemoral Pain Syndrome
NCT06913426Not specifiedACTIVE_NOT_RECRUITINGEffects of Pelvic Tilt Exercises Along With Hip and Knee Focused Exercises on Patients With Patellofemoral Pain Syndrome
NCT07004881Not specifiedRECRUITINGComparison Between the Effects of Mulligan and Maitland Mobilization on Patellofemoral Pain Syndrome
NCT07013617Not specifiedNOT_YET_RECRUITINGEffect of Specific Versus General Hamstring Stretch on Clinical Outcomes in Patellofemoral Pain Syndrome (PFPS)
NCT07064044Not specifiedNOT_YET_RECRUITINGMuscle Energy Technique With and Without Patellar Inferior Glide in Patients With Patellofemoral Pain Syndrome
NCT07290296Not specifiedRECRUITINGPopliteus Muscle Release Versus Kinesio Taping
NCT07318987Not specifiedRECRUITINGEFFECT OF SAPHENOUS NERVE RELEASE ON PATIENTS WITH PATELLOFEMORAL PAIN SYNDROME
NCT07411027Not specifiedNOT_YET_RECRUITINGBody Awareness-Based Rehabilitation on Physical Psychosocial Status in Patellofemoral Pain Syndrome
NCT07423819Not specifiedNOT_YET_RECRUITINGSports Rehabilitation Therapy for Knee Joint Sports Injuries: A Case Study of Anterior Cruciate Ligament Injury and Patellar Chondromalacia
NCT07445607Not specifiedNOT_YET_RECRUITINGMulligan Technique vs Phonophoresis With Chitosan for Patellofemoral Pain
NCT07465380Not specifiedNOT_YET_RECRUITINGStabilization vs Corrective Exercise in PFP

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
HYLAN G-F 2031
CHEMBL44323202

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 21

This page pulls from 21 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogenccgwasgwas_studyhgncmeddramedgenmeshmimmondomondochildmondoparentorphanetsctiduberonumls