Pediatric acute respiratory distress syndrome
diseaseOn this page
Also known as PARDS
Summary
Pediatric acute respiratory distress syndrome (MONDO:0100131) is a disease and 8 clinical trials. Top therapeutic interventions include desflurane. A subtype of acute respiratory distress syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Phenotypes (HPO): 16
- Clinical trials: 8
Clinical features
Signs & symptoms
Clinical features (HPO)
16 HPO clinical features (Orphanet curated; top 16 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0012418 | Hypoxemia | Very frequent (80-99%) |
| HP:0000765 | Abnormal thorax morphology | Frequent (30-79%) |
| HP:0000961 | Cyanosis | Frequent (30-79%) |
| HP:0001622 | Premature birth | Frequent (30-79%) |
| HP:0002789 | Tachypnea | Frequent (30-79%) |
| HP:0002878 | Respiratory failure | Frequent (30-79%) |
| HP:0030863 | Nasal flaring | Frequent (30-79%) |
| HP:0100598 | Pulmonary edema | Frequent (30-79%) |
| HP:0100750 | Atelectasis | Frequent (30-79%) |
| HP:0001649 | Tachycardia | Occasional (5-29%) |
| HP:0001662 | Bradycardia | Occasional (5-29%) |
| HP:0001695 | Cardiac arrest | Occasional (5-29%) |
| HP:0002090 | Pneumonia | Occasional (5-29%) |
| HP:0002615 | Hypotension | Occasional (5-29%) |
| HP:0011947 | Respiratory tract infection | Occasional (5-29%) |
| HP:0100806 | Sepsis | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | pediatric acute respiratory distress syndrome |
| Mondo ID | MONDO:0100131 |
| Orphanet | 685082 |
| UMLS | C6012346 |
| MedGen | 1876564 |
| GARD | 0027370 |
| Is cancer (heuristic) | no |
Also known as: PARDS
Disease family
This is a subtype of acute respiratory distress syndrome. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › acute disease › acute respiratory failure › acute respiratory distress syndrome › pediatric acute respiratory distress syndrome
Related subtypes (1): adult acute respiratory distress syndrome
Subtypes (1): newborn respiratory distress syndrome
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 8.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 6 |
| PHASE4 | 1 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05783518 | PHASE4 | UNKNOWN | Effect of Desflurane on Pediatric Acute Respiratory Distress Syndrome After Living Donor Liver Transplant Recipients |
| NCT07123961 | PHASE2 | RECRUITING | Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial |
| NCT06051292 | Not specified | RECRUITING | Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement |
| NCT06369584 | Not specified | RECRUITING | Prone Position During ECMO in Pediatric Patients With Severe ARDS |
| NCT06684119 | Not specified | RECRUITING | Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT) |
| NCT06836050 | Not specified | RECRUITING | IPV and Lung Compliance in Invasively Ventilated Children |
| NCT03585582 | Not specified | UNKNOWN | Post-discharge Outcomes of Pediatric Acute Respiratory Distress Syndrome |
| NCT06586411 | Not specified | COMPLETED | Comparison of Oxygenation Index and Oxygen Stretch Index |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DESFLURANE | 4 | 1 |
Related Atlas pages
- Drugs: Desflurane