Pediatric multiple sclerosis

Summary

Pediatric multiple sclerosis (MONDO:0018784) is a disease and 7 clinical trials. A subtype of multiple sclerosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 7

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	pediatric multiple sclerosis
Mondo ID	MONDO:0018784
Orphanet	477738
UMLS	C5568571
MedGen	1799994
GARD	0010443
Is cancer (heuristic)	no

Also known as: MS paediatric · MS pediatric · multiple sclerosis, paediatric · multiple sclerosis, pediatric · paediatric MS · pediatric MS

Disease family

This is a subtype of multiple sclerosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › autoimmune disorder of central nervous system › multiple sclerosis › pediatric multiple sclerosis

Related subtypes (3): chronic progressive multiple sclerosis, relapsing-remitting multiple sclerosis, Marburg acute multiple sclerosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 7.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	7

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04782466	Not specified	ACTIVE_NOT_RECRUITING	ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research Program
NCT01396343	Not specified	COMPLETED	Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis
NCT03066752	Not specified	COMPLETED	Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes
NCT03067025	Not specified	COMPLETED	Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis
NCT03137602	Not specified	COMPLETED	ATOMIC (Active Teens With MultIple sClerosis) Teens: A Feasibility Study
NCT04441229	Not specified	COMPLETED	Mobile Attentional Bias Modification Training in Pediatric MS
NCT04660227	Not specified	COMPLETED	Exercise Training in Pediatric-Onset Multiple Sclerosis Patients