Peeling skin syndrome

Summary

Peeling skin syndrome (MONDO:0019347) is a disease (an umbrella term covering 5 Mondo subtypes) and 1 clinical trial. A subtype of inherited ichthyosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Umbrella term: 5 Mondo subtypes
• Clinical trials: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	peeling skin syndrome
Mondo ID	MONDO:0019347
OMIM	270300
Orphanet	817
DOID	DOID:0060283
ICD-11	523640904
SNOMED CT	239065004
UMLS	C1849193
MedGen	336530
GARD	0007347
NORD	1562
Is cancer (heuristic)	no

Also known as: deciduous skin · familial continuous skin peeling · familial continuous skin peeling syndrome · idiopathic deciduous skin · keratosis exfoliativa congenita · peeling skin disease · PSS · skin peeling syndrome

Disease family

This is a subtype of inherited ichthyosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › integumentary system disorder › skin disorder › epidermal disease › ichthyosis › inherited ichthyosis › peeling skin syndrome

Related subtypes (12): congenital cataract-ichthyosis syndrome, Netherton syndrome, ichthyosis-oral and digital anomalies syndrome, recessive X-linked ichthyosis, neonatal ichthyosis-sclerosing cholangitis syndrome, autosomal recessive congenital ichthyosis, keratinopathic ichthyosis, ichthyosis vulgaris, ichthyosis linearis circumflexa, IFAP syndrome, ichthyosis hystrix, ichthyosis with erythrokeratoderma

Subtypes (5): generalized peeling skin syndrome, peeling skin syndrome 4, acral peeling skin syndrome, peeling skin syndrome 5, peeling skin syndrome 6

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06749561	Not specified	ACTIVE_NOT_RECRUITING	A Comparative Investigation of Efficacy and Complications in Light and Deep Chemical Peels