Peptic ulcer perforation

Summary

Peptic ulcer perforation (MONDO:0004260) is a disease and 8 clinical trials. A subtype of peptic ulcer disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 8

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	peptic ulcer perforation
Mondo ID	MONDO:0004260
EFO	EFO:1001389
MeSH	D010439
DOID	DOID:752
SNOMED CT	79118000
UMLS	C0030925
MedGen	45385
Is cancer (heuristic)	no

Disease family

This is a subtype of peptic ulcer disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › peptic ulcer disease › peptic ulcer perforation

Related subtypes (5): gastric ulcer, gastrojejunal ulcer, active peptic ulcer disease, duodenal ulcer, peptic esophagitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 8.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	7
PHASE4	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01620671	PHASE4	COMPLETED	Fast-track Surgery for Perforated Peptic Ulcers
NCT00624169	Not specified	COMPLETED	Peptic Ulcer Perforation Study
NCT01376414	Not specified	COMPLETED	H. Pylori Testing for Patients With Non-specific Upper Abdominal Pain in the Emergency Department
NCT04194060	Not specified	COMPLETED	ERAS vs Conventional Approach in Peptic Perforation-RCT
NCT04447170	Not specified	UNKNOWN	Laparoscopic Versus Open Repair of Peptic Ulcer Perforation
NCT05489497	Not specified	COMPLETED	Morbidity After Surgical Treatment of Perforated Ulcer
NCT06042933	Not specified	COMPLETED	Early Oral Feeding Versus Traditional Delayed Oral Feeding Post-perforated Peptic Ulcer Repair
NCT06084741	Not specified	COMPLETED	Omitting Drains After Repair of Peptic Ulcer Perforations