Periampullary adenocarcinoma
disease diseaseOn this page
Also known as periampullary cancerperiampullary region of duodenum adenocarcinoma
Summary
Periampullary adenocarcinoma (MONDO:0004465) is a disease and 35 clinical trials. Top therapeutic interventions include cisplatin, cediranib maleate, and tezemlimogene daxadenorepvec. A subtype of ampulla of vater adenocarcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 35
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | periampullary adenocarcinoma |
| Mondo ID | MONDO:0004465 |
| DOID | DOID:8110 |
| NCIT | C27322 |
| UMLS | C1335377 |
| MedGen | 233847 |
| GARD | 0024020 |
| Anatomy (UBERON) | UBERON:0012273 |
| Is cancer (heuristic) | no |
Also known as: periampullary adenocarcinoma · periampullary cancer · periampullary region of duodenum adenocarcinoma
Data availability: 1 cell line.
Disease family
This is a subtype of ampulla of vater adenocarcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease by body system or component › digestive system disorder › digestive system cancer › liver cancer › biliary tract cancer › bile duct cancer › bile duct carcinoma › extrahepatic bile duct carcinoma › extrahepatic bile duct adenocarcinoma › ampulla of vater adenocarcinoma › periampullary adenocarcinoma
Related subtypes (3): ampullary signet ring cell adenocarcinoma, ampulla of vater mucinous adenocarcinoma, ampulla of vater clear cell adenocarcinoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 35.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 22 |
| PHASE2 | 6 |
| PHASE1 | 4 |
| PHASE3 | 3 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05843877 | PHASE3 | RECRUITING | Pancreatic Head Resection or Total Pancreatectomy With Islet Autotransplantation in Patients With Periampullary Cancer and High Risk Profile for the Development of Postoperative Pancreatic Fistula |
| NCT07081360 | PHASE3 | RECRUITING | Neoadjuvant vs Upfront Surgery for Resectable Pancreatic Cancer and Periampullary Cancer |
| NCT07155525 | PHASE3 | RECRUITING | Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas |
| NCT07230509 | PHASE2 | RECRUITING | Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate |
| NCT00832637 | PHASE2 | TERMINATED | Gemcitabine, Oxaliplatin, Tarceva &/or Cisplatin in HCC & Biliary Tree Cancers |
| NCT01229111 | PHASE2 | TERMINATED | Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers |
| NCT01781728 | PHASE2 | COMPLETED | Palliative Stereotactic Radiation for Pancreatic or Periampullary Adenocarcinoma |
| NCT01811277 | PHASE2 | UNKNOWN | SOX Sequential S-1 in Advanced Biliary Tract Carcinoma（BTC）and Pancreatic Cancer |
| NCT05289830 | PHASE2 | TERMINATED | Escitalopram to Placebo in Patients With Localized Pancreatic Cancer |
| NCT07132541 | PHASE1 | RECRUITING | Saleh’s Technique for Pancreaticojejunostomy (Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate) |
| NCT00983268 | PHASE1 | COMPLETED | Capecitabine, Vorinostat, and Radiation Therapy in Treating Patients With Nonmetastatic Pancreatic Cancer |
| NCT00987766 | PHASE1 | COMPLETED | Gemcitabine Hydrochloride, Oxaliplatin, and Erlotinib Hydrochloride in Treating Patients With Advanced Biliary Tract Cancer, Pancreatic Cancer, Duodenal Cancer, or Ampullary Cancer |
| NCT04714983 | PHASE1 | SUSPENDED | DNX-2440 for Resectable Colorectal Liver Metastasis |
| NCT02757859 | Not specified | ACTIVE_NOT_RECRUITING | WASH Trial: Intraoperative Lavage as a Treatment for Pancreatic Cancer |
| NCT05155878 | Not specified | RECRUITING | Prognostic Factors in Periampullary Tumors and Cysts |
| NCT05788029 | Not specified | ENROLLING_BY_INVITATION | Comparing Laparoscopic and Open Pancreaticoduodenectomy for Nonpancreatic Periampullary Adenocarcinomas |
| NCT06069297 | Not specified | RECRUITING | Prehabilitation in Pancreatic Surgery |
| NCT06381882 | Not specified | ENROLLING_BY_INVITATION | The Role of the Human Microbiome in Patients After Pancreatic Resection. |
| NCT07009119 | Not specified | RECRUITING | Laparoscopic Pancreaticoduodenectomy |
| NCT07022015 | Not specified | RECRUITING | Predictive Risk Factors for Pancreatic Fistula After Pancreaticoduodenectomy |
| NCT00841607 | Not specified | COMPLETED | Reconstruction Following Pancreaticoduodenectomy: A Randomized Clinical Trial of Pancreaticojejunostomy vs Pancreaticogastomy |
| NCT01789502 | Not specified | COMPLETED | Comparison Between Fully Covered Metal Stents and Plastic Stents in Preoperative Biliary Drainage |
| NCT01913275 | Not specified | WITHDRAWN | Comparison Between Endoscopic Stenting and Cholecystojejunostomy for PreoperativeDrainage Before Pancreaticoduodenectomy |
| NCT02787512 | Not specified | COMPLETED | Preoperative Biliary Drainage With Metal Versus Plastic Stents in Periampullary Cancer |
| NCT02900950 | Not specified | COMPLETED | Multicolour Versus Monocolour Specimens Inking After Pancreaticoduodenectomy for Periampullary Cancer |
| NCT03063554 | Not specified | UNKNOWN | EUS BD vs ERCP TP for Pancreatic Cancer |
| NCT03138213 | Not specified | UNKNOWN | Comparing Total Laparoscopic Versus Open Pancreaticoduodenectomy |
| NCT03724994 | Not specified | COMPLETED | Chemotherapy, Host Response and Molecular Dynamics in Periampullary Cancer |
| NCT03870698 | Not specified | COMPLETED | Comparison of Functional Recovery Between Laparoscopic and Open Pancreaticoduodenectomy |
| NCT04095312 | Not specified | UNKNOWN | Clinical Study for Evaluating the Clinical Safety and Effectiveness of the Automated Robotic Robot, Revo-i Surgical Robot System (Model MSR-5100), Used for General Endoscopic Surgery. |
| NCT04289831 | Not specified | COMPLETED | Preoperative Biliary Drainage in Patients With Operable Malignant Periampulary Tumors |
| NCT04311047 | Not specified | TERMINATED | Preoperative Detection of Lymph Node Metastases in Pancreatic and Periampullary Carcinoma Using USPIO MRI |
| NCT04401722 | Not specified | COMPLETED | Clinical Impact of Altitude Level on Surgical Outcomes of Pancreaticoduodenectomy |
| NCT04985071 | Not specified | COMPLETED | Complication of Pancreatic Fistula and Bleeding After Pancreaticoduodenectomy in Treatment Periampullary Cancer |
| NCT06009224 | Not specified | UNKNOWN | The Effect of ERAS on Pancreaticoduodenectomy (v2.0) |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CISPLATIN | 4 | 1 |
| CEDIRANIB MALEATE | 3 | 1 |
| TEZEMLIMOGENE DAXADENOREPVEC | 2 | 1 |