Periapical granuloma

Summary

Periapical granuloma (MONDO:0006897) is a disease and 3 clinical trials. A subtype of periapical periodontitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	periapical granuloma
Mondo ID	MONDO:0006897
EFO	EFO:1001096
MeSH	D010484
DOID	DOID:4617
SNOMED CT	81407003
UMLS	C0031029
MedGen	45395
MedDRA	10060985
Is cancer (heuristic)	no

Disease family

This is a subtype of periapical periodontitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › periodontal disorder › periodontitis › periapical periodontitis › periapical granuloma

Related subtypes (3): chronic apical periodontitis, acute apical periodontitis, suppurative periapical periodontitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05256667	PHASE2/PHASE3	UNKNOWN	Comparison Between RCT in Single and Two Visits, With and Without Intracanal Dressing, in Apical Repair
NCT06521203	Not specified	COMPLETED	Periapical Lesions and Immediate Implants
NCT06643676	Not specified	COMPLETED	Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars