◎ Sugi Atlas

Atlas / Disease / Periapical periodontitis

Periapical periodontitis

disease
On this page

Summary

Periapical periodontitis (MONDO:0004508) is a disease and 53 clinical trials. Top therapeutic interventions include hydrogen peroxide, minocycline, and sodium hypochlorite. A subtype of periodontitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 53

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical nameperiapical periodontitis
Mondo IDMONDO:0004508
EFOEFO:1001391
MeSHD010485
DOIDDOID:823
ICD-111395124674
SNOMED CT39273001
UMLSC0031030
MedGen45396
Is cancer (heuristic)no

Disease family

This is a subtype of periodontitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › periodontal disorder › periodontitis › periapical periodontitis

Related subtypes (3): acute pericementitis, chronic periodontitis, pericoronitis

Subtypes (4): chronic apical periodontitis, acute apical periodontitis, periapical granuloma, suppurative periapical periodontitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated or in trials for this disease

No drug has an approved disease-direct ChEMBL indication for this disease.

3 drugs in clinical trials for this disease (phase 2–3, investigational): efficacy not established — a trial record, not an indication.

DrugHighest phase
AmoxicillinPhase 2
Clavulanic AcidPhase 2
ClindamycinPhase 2

Clinical trials & evidence

Clinical trials

Clinical trials: 53.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified48
PHASE12
PHASE41
PHASE21
EARLY_PHASE11

Top trials by phase / activity

NCTPhaseStatusTitle
NCT01817413PHASE4COMPLETEDComparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma
NCT02747082PHASE2COMPLETEDAntibacterial Effectiveness of Two Root Canal Irrigants
NCT02947763PHASE1COMPLETEDSingle Versus Multiple Visits Endodontic Treatment
NCT05599087PHASE1UNKNOWNEncapsulated Acellular System From Mesenchymal Stem Cells for Dental Pulp Regeneration
NCT00226148EARLY_PHASE1COMPLETEDImmediate Implant Placement in the Molar Regions
NCT05763420Not specifiedENROLLING_BY_INVITATIONClinical Efficacy of AH Plus Bioceramic Sealer
NCT07018284Not specifiedRECRUITINGPostoperative Pain Evaluation After Obturation With Different Sealers
NCT07019298Not specifiedRECRUITINGSuccess of Endodontic Treatment With Different Obturation Techniques and Sealer Cements
NCT07197658Not specifiedRECRUITINGHealing After Endodontic Microsurgery Using a Rotary Bur Versus Piezoelectric Unit for Osteotomy and Root Resection
NCT07239739Not specifiedNOT_YET_RECRUITINGComparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment
NCT07239752Not specifiedNOT_YET_RECRUITINGInfluence of Maintaining Apical Patency on Post-Endodontic Pain in Molars
NCT07252258Not specifiedACTIVE_NOT_RECRUITINGComparison of Frequency of Calcium Hydroxide Mixed With 0.2% Chlorhexidine Versus Saline as Intracanal Medicament in Periapical Periodontitis-A Randomized Controlled Trial
NCT07343804Not specifiedRECRUITINGTHE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE
NCT07418840Not specifiedNOT_YET_RECRUITINGClinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic Retreatments
NCT07439614Not specifiedNOT_YET_RECRUITINGComparison of Root Canal Desinfection Protocols
NCT07501585Not specifiedRECRUITINGHyaluronic Acid in Endodontic Microsurgery
NCT00223327Not specifiedCOMPLETEDMeasurement of Bite Force in Humans
NCT00762840Not specifiedUNKNOWNSafety and Efficacy of the Apexum Ablator
NCT01312194Not specifiedCOMPLETEDPeriapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients
NCT01799187Not specifiedUNKNOWNResearch of Revascularization in Immature Teeth With Periapical Periodontitis
NCT02528240Not specifiedCOMPLETEDEndodontic Microsurgery With the Use of L-PRF and an Occlusive Membrane: a Randomized Controlled Clinical Trial
NCT02632513Not specifiedCOMPLETEDEffect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment
NCT02801552Not specifiedCOMPLETEDRegenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF
NCT03102879Not specifiedCOMPLETEDEncapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
NCT03537664Not specifiedCOMPLETEDAdjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections
NCT03660163Not specifiedUNKNOWNAssessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography.
NCT03708081Not specifiedCOMPLETEDComparative Evaluation of Different File Systems in Postoperative Pain
NCT03918733Not specifiedUNKNOWNComparision of Non Surgical Retreatment and Endodontic Surgery of Failed Root Canal Treated Teeth
NCT03990584Not specifiedCOMPLETEDEffects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment
NCT04358861Not specifiedCOMPLETEDHealing Outcome of Root Canal Therapy in Maxillary Molars With DOM
NCT04373018Not specifiedUNKNOWNEvaluation of Three Irrigants, Sodium Hypochlorite, Chlorhexidine and Combination of CHX+H2O2 in Endodontic Treatment.
NCT04495270Not specifiedCOMPLETED2-year Treatment Outcomes of Teeth Estimated by Means of Periapical and Endodontic Status Scale
NCT04812171Not specifiedCOMPLETEDHealing of Apical periodontitis-the Effect of Diabetes Mellitus and Tobacco Smoking
NCT04978545Not specifiedCOMPLETEDThe Effect of Ca(OH)2 in Apical Periodontitis
NCT04980768Not specifiedUNKNOWNAssociation of Apical Periodontitis With Hs-CRP and Hemogram Indices
NCT05297747Not specifiedCOMPLETEDAdrenomedullin Upregulation in Apical Periodontitis
NCT05525013Not specifiedCOMPLETEDEffect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8
NCT05555043Not specifiedCOMPLETEDComparison of Clinical Outcomes Between GentleWave® and Biolase®
NCT05585359Not specifiedUNKNOWNEffect of Injectable Platelet Rich Fibrin Augmented With Vitamin C Compared to Injectable Platelet Rich Fibrin Alone on Healing of Necrotic Mature Single Rooted Teeth With Chronic Peri-apical Periodontitis Following Regenerative Endodontics (A Randomized Controlled Trial)
NCT05690763Not specifiedCOMPLETEDQuantitative Assessment of the Efficacy of Two Irrigation Activation Systems

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
HYDROGEN PEROXIDE41
MINOCYCLINE41
SODIUM HYPOCHLORITE41
CALCIUM HYDROXIDE33

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 20

This page pulls from 20 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogenccgwasgwas_studyhgncicd11medgenmeshmimmondomondochildmondoparentorphanetsctidumls