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Atlas / Disease / Perihilar intrahepatic cholangiocarcinoma

Perihilar intrahepatic cholangiocarcinoma

disease
On this page

Also known as perihilar bile duct carcinomaperihilar cholangiocarcinomaperihilar ICC

Summary

Perihilar intrahepatic cholangiocarcinoma (MONDO:0044788) is a disease and 18 clinical trials. Top therapeutic interventions include cisplatin. A subtype of intrahepatic cholangiocarcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 18

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical nameperihilar intrahepatic cholangiocarcinoma
Mondo IDMONDO:0044788
NCITC96804
GARD0025911
Is cancer (heuristic)no

Also known as: perihilar bile duct carcinoma · perihilar cholangiocarcinoma · perihilar ICC · perihilar intrahepatic cholangiocarcinoma

Disease family

This is a subtype of intrahepatic cholangiocarcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › digestive system cancer › liver cancer › biliary tract cancer › bile duct cancer › intrahepatic bile duct cancer › intrahepatic cholangiocarcinoma › perihilar intrahepatic cholangiocarcinoma

Related subtypes (5): hilar cholangiocarcinoma, mucinous intrahepatic cholangiocarcinoma, cholangiolocellular carcinoma, signet ring cell intrahepatic cholangiocarcinoma, sarcomatous intrahepatic cholangiocarcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 18.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified13
PHASE24
PHASE2/PHASE31

Top trials by phase / activity

NCTPhaseStatusTitle
NCT06923475PHASE2/PHASE3NOT_YET_RECRUITINGNeoadjuvant Gemcitabine and Cisplatin in Combination With Perioperative Pembrolizumab Versus Upfront Surgery for Patients With Primary Resectable and Borderline Resectable Perihilar and Distal Cholangiocarcinoma
NCT05430698PHASE2RECRUITINGPD-1 Antibody Plus GEMOX as Postoperative Adjuvant Therapy in Perihilar Cholangiocarcinoma
NCT07471165PHASE2NOT_YET_RECRUITINGA Prospective, Single-Arm, Phase II Study: PD-L1 Monoclonal Antibody + Chemoradiotherapy as Bridge Therapy to Liver Transplantation for Locally Advanced Perihilar Cholangiocarcinoma (ACHIEVE-LT)
NCT05024513PHASE2COMPLETEDBiliary Drainage Plus HAIC in Locally Advanced pCCA
NCT06739252PHASE2TERMINATEDPerioperative Treatment of High-risk Resectable CCA With HAIC Plus A+T: Neobrave CCA
NCT04993131Not specifiedRECRUITINGLiver Transplantation for Non-resectable Perihilar Cholangiocarcinoma
NCT05546372Not specifiedRECRUITINGEndobiliary Radiofrequency Ablation for Malignant Biliary Obstruction Due to Perihilar Cholangiocarcinoma
NCT06125769Not specifiedRECRUITINGLIver TrAnspLantation for Non-resectable Peri-HIlar cholangioCArcinoma (LITALHICA)
NCT06720883Not specifiedRECRUITINGRobotically Assisted Surgery For Perihilar Cholangiocarcinoma: A Prospective Study
NCT06986486Not specifiedRECRUITINGLiver Transplantation for Unresectable Perihilar Cholangiocarcinoma
NCT07161869Not specifiedNOT_YET_RECRUITINGPreoperative Evaluation of Lymph Nodes of Cholangiocarcinoma (POELH-III)
NCT04561453Not specifiedTERMINATEDFeasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer
NCT04846192Not specifiedUNKNOWNPrognosis of Nutritional Status for Surgical Peri Hilar Cholangiocarcinoma
NCT05078801Not specifiedUNKNOWNEndoscopic Versus Radiologic Biliary Drainage for Perihilar Malignant Obstruction
NCT05402618Not specifiedCOMPLETEDMinimally Invasive Versus Open Surgery for PHC
NCT05563870Not specifiedUNKNOWNEndoscopy and Radiology-guided Ablation for Inoperable Cholangiocarcinoma
NCT05874934Not specifiedCOMPLETEDEndoscopic Drainage of Presumed Resectable pCCA Using an Intrahepatic Plastic Stent With Retrieval String
NCT06357117Not specifiedCOMPLETEDExtent of Intrahepatic Infiltration of Perihilar Cholangiocarcinoma

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
CISPLATIN41

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 17

This page pulls from 17 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvarefogardgenccgwasgwas_studyhgncmeshmimmondomondochildmondoparentncitorphanet