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Atlas / Disease / Periodontal disorder

Periodontal disorder

disease
On this page

Also known as disease of periodontiumdisease or disorder of periodontiumdisorder of periodontiumperiodontal diseaseperiodontium diseaseperiodontium disease or disorder

Summary

Periodontal disorder (MONDO:0002635) is a disease with 20 GWAS associations across 8 studies and 674 clinical trials. Top therapeutic interventions include chlorhexidine, doxycycline anhydrous, and methylene blue cation. A subtype of skeletal system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • GWAS associations: 20
  • Clinical trials: 674

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical nameperiodontal disorder
Mondo IDMONDO:0002635
MeSHD010510
DOIDDOID:3388
NCITC63743
SNOMED CT2556008
UMLSC0031090
MedGen10658
Anatomy (UBERON)UBERON:0001758
Is cancer (heuristic)no

Also known as: disease of periodontium · disease or disorder of periodontium · disorder of periodontium · periodontal disease · periodontal disorder · periodontium disease · periodontium disease or disorder

Data availability: 20 GWAS associations (8 studies).

Disease family

This is a subtype of skeletal system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › periodontal disorder

Related subtypes (47): symphalangism, cartilage cancer, vertebral column disorder, patellar tendinitis, necrosis of ear ossicle, laryngeal cartilage cancer, ochronosis disorder, chondroma, posterior cranial fossa meningioma, anterior cranial fossa meningioma, middle cranial fossa meningioma, bone marrow disorder, cranial nodular fasciitis, flatfoot, bone disorder, skeletal tuberculosis, arthropathy, tooth disorder, primary basilar invagination, Brachymorphism-onychodysplasia-dysphalangism syndrome, cherubism, fibrodysplasia ossificans progressiva, Marfan syndrome, Buschke-Ollendorff syndrome, scalp defects-postaxial polydactyly syndrome, cartilage-hair hypoplasia, Teebi-Shaltout syndrome, short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome, ossification of the posterior longitudinal ligament of the spine, temtamy preaxial brachydactyly syndrome, metaphyseal undermodeling, spondylar dysplasia, and overgrowth, Al-Gazali syndrome, brachydactyly-syndactyly syndrome, endocrine-cerebro-osteodysplasia syndrome, metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria, multiple congenital anomalies-hypotonia-seizures syndrome 3, Rienhoff syndrome, Coffin-Siris syndrome, microcephaly-brachydactyly-kyphoscoliosis syndrome, cartilage development disorder, syndactyly, polydactyly, brachydactyly, sternal neoplasm, short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis, skeletal ligament disorder, brachydactyly-syndactyly-oligodactyly syndrome

Subtypes (4): gingival disorder, periodontitis, Papillon-Lefevre disease, regional odontodysplasia

Genetics & variants

GWAS landscape

20 GWAS associations across 8 studies. Top hits map to 10 distinct genes (as reported by GWAS).

Top associations by p-value

rsIDp-valueGeneRisk alleleOdds ratio
rs48018822e-08SIGLEC5G5.66
rs126245795e-07SYNDIG1T0.74
rs1423644481e-06LARP1BG1.46
rs751461591e-06DHFRP5 - FKBP1CG1.19
rs2012373213e-06LINC01141 - CAMK2N1A1.22
rs716249373e-06PPARG - TSEN2A1.39
rs753849993e-06CFAP44A1.21
rs118777434e-06NPM1P1 - PIK3C3A0.89
rs1170702664e-06MBPT1.25
rs117030144e-06EPIC1 - MIR3201T2.66
rs728339315e-06AAK1T1.15
rs169515305e-06LINC01228 - DYNLRB2-AS1A1.12
rs126033366e-06CCR7 - SMARCE1C1.11
rs38977096e-06LINC01904 - SLC25A3P3G0.91
rs1469493187e-06LINC01676 - SEPTIN2P1A1.64
rs76367527e-06KALRNC0.92
rs5502838297e-06FCHO2CTATT1.65
rs728961868e-06ITGA4C1.1
rs168445468e-06LINC02789G1.24
rs1447935648e-06CHCHD4P2 - RPL36P14C1.54

Top studies (by case count)

StudyLead authorYearCasesControlsTitle
GCST90565219Nogawa S202436,332470,262Genome-wide association meta-analysis identifies two novel loci associated with dental caries.
GCST90565217Nogawa S20247,05938,466Genome-wide association meta-analysis identifies two novel loci associated with dental caries.
GCST90473757UK Biobank Whole-Genome Sequencing Consortium20251,934456,506Whole-genome sequencing of 490,640 UK Biobank participants.
GCST90080170Backman JD20211,081386,036Exome sequencing and analysis of 454,787 UK Biobank participants.
GCST90084156Backman JD20211,081386,036Exome sequencing and analysis of 454,787 UK Biobank participants.
GCST90726972Kim HI202691243,114Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity.
GCST90473758UK Biobank Whole-Genome Sequencing Consortium2025809457,631Whole-genome sequencing of 490,640 UK Biobank participants.
GCST90726973Kim HI202637343,653Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

TierVariants
Tier 1: coding0
Tier 2: splice/UTR1
Tier 3: regulatory0
Tier 4: intronic/intergenic19

MAF distribution

BucketVariants
common (>=0.05)12
low_freq (0.01-0.05)8
rare (<0.01)0
unknown0

Functional consequences

ConsequenceCount
intron_variant10
intergenic_variant9
3_prime_UTR_variant1

Top variants

rsIDChrPosAllelesMAFConsequenceGenep-valueTier
rs48018821951623800G>A0.05intron_variantSIGLEC52e-08Tier 4: intronic/intergenic
rs126245792024507057C>T0.079intron_variantSYNDIG15e-07Tier 4: intronic/intergenic
rs1423644484128066678A>G0.022intron_variantLARP1B1e-06Tier 4: intronic/intergenic
rs75146159663210372A>G0.073intergenic_variantDHFRP5 - FKBP1C1e-06Tier 4: intronic/intergenic
rs201237321120454485G>A0.075intergenic_variantLINC01141 - CAMK2N13e-06Tier 4: intronic/intergenic
rs71624937312448369G>A,T0.019intergenic_variantPPARG - TSEN23e-06Tier 4: intronic/intergenic
rs753849993113332981G>A0.072intron_variantCFAP443e-06Tier 4: intronic/intergenic
rs118777431841816792A>G0.216intergenic_variantNPM1P1 - PIK3C34e-06Tier 4: intronic/intergenic
rs1170702661876996198C>A,T0.042intron_variantMBP4e-06Tier 4: intronic/intergenic
rs117030142248102600C>T0.013intergenic_variantEPIC1 - MIR32014e-06Tier 4: intronic/intergenic
rs72833931269462377A>T0.1353_prime_UTR_variantAAK15e-06Tier 2: splice/UTR
rs169515301679848461G>A0.179intergenic_variantLINC01228 - DYNLRB2-AS15e-06Tier 4: intronic/intergenic
rs126033361740613955T>C0.254intergenic_variantCCR7 - SMARCE16e-06Tier 4: intronic/intergenic
rs389770918936511A>G0.349intergenic_variantLINC01904 - SLC25A3P36e-06Tier 4: intronic/intergenic
rs1469493181105669907T>A,G0.011intron_variantLINC01676 - SEPTIN2P17e-06Tier 4: intronic/intergenic
rs76367523124257947T>A,C,G0.493intron_variantKALRN7e-06Tier 4: intronic/intergenic
rs550283829573050295C>CTATCTATCTATT,CTATCTATCTATTTATT,CTATCTATT,CTATCTATTTATT,CTATCTATTTATTTATT,CTATCTATTTATTTATTTATT,CTATCTCTT0.025intron_variantFCHO27e-06Tier 4: intronic/intergenic
rs728961862181465856T>C,G0.285intron_variantITGA48e-06Tier 4: intronic/intergenic
rs168445461199280238T>C,G0.04intron_variantLINC027898e-06Tier 4: intronic/intergenic
rs1447935649108205577T>C0.011intergenic_variantCHCHD4P2 - RPL36P148e-06Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

DrugDevelopment status
Sodium FluoridePhase 3 (in late-stage trials)
TriclosanPhase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Aloe, Amoxicillin, Chlorhexidine, Metronidazole, Olive Oil, Propolis Wax, Sodium Chloride.

Clinical trials & evidence

Clinical trials

Clinical trials: 674.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified577
PHASE439
PHASE321
PHASE216
PHASE1/PHASE26
PHASE2/PHASE35
EARLY_PHASE15
PHASE15

Top trials by phase / activity

NCTPhaseStatusTitle
NCT04669717PHASE4RECRUITINGAntibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies
NCT06894667PHASE4ACTIVE_NOT_RECRUITINGThe Effect of an Antioxidant Gel Compared to Chlorhexidine Gel During the Soft Tissue Healing Process: A Randomized Controlled Clinical Trial
NCT07489924PHASE4ACTIVE_NOT_RECRUITINGMicrobiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (Lactobacillus Reuteri Prodentis) on Porphyromonas Gingivalis.
NCT07602309PHASE4NOT_YET_RECRUITINGTedlar Bag Stability of Volatile Sulfur Compounds for Remote Halitosis Diagnosis
NCT00064766PHASE4UNKNOWNNorplant and Irregular Bleeding/Spotting
NCT00594334PHASE4WITHDRAWNEffect of Actonel on Periodontal Health of Postmenopausal Women
NCT00757159PHASE4COMPLETEDStudy on Regenerative Treatment of Intra-bony Defects
NCT01591616PHASE4COMPLETEDPediatric Study to Access Pharmacokinetics and Safety of Oraqix Gel
NCT01798225PHASE4COMPLETEDRelationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population
NCT02102360PHASE4COMPLETEDConventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial.
NCT02185209PHASE4COMPLETEDSurgical Treatment of Peri-implantitis With and Without Systemically Adjunctive Antibiotics
NCT02202304PHASE4WITHDRAWNThe Effects of Chlorhexidine/Thymol Varnish on Partial Denture Patient
NCT02461030PHASE4COMPLETEDEfficacy of Two Oral Hygiene Regimens in the Reduction of Dentin Hypersensitivity After Periodontal Treatment
NCT02474498PHASE4COMPLETEDEMD and/or Bone Substitute for the Treatment of Class II Furcations
NCT02487186PHASE4COMPLETEDLocally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy.
NCT02500654PHASE4COMPLETEDRegenerative Surgical Treatment of Peri-implantitis
NCT02666573PHASE4COMPLETEDPhotodynamic Therapy During Supportive Periodontal Therapy
NCT02670135PHASE4COMPLETEDClinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers
NCT02826109PHASE4UNKNOWNThe Efficacy of Cyanoacrylate Adhesive (PeriAcryl®90 HV) in Periodontal Wound Healing
NCT02935322PHASE4COMPLETEDInteraction Between Chlorhexidine and Fluoride
NCT02987634PHASE4UNKNOWNEvaluation and Comparison of Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Mouth Rinse
NCT03219840PHASE4COMPLETEDCetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
NCT03368430PHASE4COMPLETEDMelatonin as an Adjunctive Therapy for Chronic Periodontitis.
NCT03452891PHASE4COMPLETEDEffect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients
NCT04059445PHASE4TERMINATEDMandibular Furcation II Regeneration
NCT04059458PHASE4TERMINATEDMandibular Furcation III Regeneration (FURC-III-REGEN)
NCT04149327PHASE4COMPLETEDSystemic Amoxicillin Plus Metronidazole in Peri-implantitis Treatment
NCT04223076PHASE4UNKNOWNClinical Effect of Chlorhexidine Mouthwash After Periodontal Surgery
NCT04422184PHASE4COMPLETEDComparative Clinical Evaluation of Three Different Agents in Reducing Dental Hypersensitivity in Periodontal Patients
NCT04450849PHASE4COMPLETEDRegenerative Potential of a Collagen Membrane Associated or Not to Bovine Bone in Class II Furcation Defects.
NCT04580355PHASE4UNKNOWNImpact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
NCT05188924PHASE4UNKNOWNEfficacy and Safety of DKF-306 in Patients With Periodontal Diseases
NCT05936450PHASE4COMPLETEDAssessment Of Healing After Periodontal Flap Surgery With And Without The Use Of Placental Extracts
NCT06836401PHASE4COMPLETEDTopical Metronidazole vs Control in Reducing Periodontal Pockets in a Split Mouth Clinical Trial
NCT06904742PHASE4COMPLETEDClinical and Microbiological Evaluation Of The Efficacy Of Herbal Mouthwashes in Gingivitis
NCT07119307PHASE4COMPLETEDPapilla Preservation Technique in Combination With Tooth Enamel Proteins and Animal Derived Bone Graft in Treating Isolated Bone Defects Between Teeth
NCT07135674PHASE4COMPLETEDEvaluation of a Herbal Antiseptic Gel as a Supportive Treatment for Teeth Cleaning in Patients With Periodontal Disease
NCT07183631PHASE4COMPLETEDHealing of Intrabony Defects Following Treatment With PRF or EMD
NCT07605767PHASE4COMPLETEDAdjunctive Topical Melatonin Gel in Non-Surgical Periodontal Therapy for Periodontitis
NCT07553286PHASE3NOT_YET_RECRUITINGPeriodontal Disease and Small Vulnerable Newborns in Rural Nepal: A Community-based Trial

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
CHLORHEXIDINE49
DOXYCYCLINE ANHYDROUS49
METHYLENE BLUE CATION43
TRICLOSAN43
LIDOCAINE42
METRONIDAZOLE42
AMOXICILLIN41
APIXABAN41
DABIGATRAN ETEXILATE41
FLUVASTATIN SODIUM41
HYALURONIC ACID41
INULIN41
MELATONIN41
METHYLCELLULOSE41
MINOCYCLINE HYDROCHLORIDE41
PENICILLIN V41
POLIHEXANIDE41
PRILOCAINE41
RISEDRONIC ACID41
FLUORIDE ION33
CETYLPYRIDINIUM32
HONEY32
PROPOLIS WAX32
CALCIUM HYDROXIDE31
CYPROTERONE ACETATE31
DABIGATRAN31
LICORICE31
NITRIC ACID31
POLIGLUSAM31
PROPYLENE GLYCOL31

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 22

This page pulls from 22 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardbsnpdoidefogenccgwasgwas_studyhgncmedgenmeshmimmondomondochildmondoparentncitorphanetsctiduberonumls