Peripartum cardiomyopathy
diseaseOn this page
Also known as Meadows' syndromepostpartum cardiomyopathy
Summary
Peripartum cardiomyopathy (MONDO:0018920) is a disease and 12 clinical trials. Top therapeutic interventions include bromocriptine, sodium chloride, and sodium selenate. A subtype of non-familial dilated cardiomyopathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 6-9 / 10 000 (Singapore) [Orphanet-validated]
- Phenotypes (HPO): 45
- Clinical trials: 12
Clinical features
Epidemiology
Prevalence records
6 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Prevalence at birth | 6-9 / 10 000 | 89 | Singapore | Validated |
| Prevalence at birth | 1-9 / 100 000 | 5 | Japan | Validated |
| Prevalence at birth | >1 / 1000 | 334 | Haiti | Validated |
| Prevalence at birth | >1 / 1000 | 100 | South Africa | Validated |
| Prevalence at birth | 1-5 / 10 000 | 30 | Worldwide | Not yet validated |
| Prevalence at birth | 1-5 / 10 000 | 36 | United States | Not yet validated |
Signs & symptoms
Clinical features (HPO)
45 HPO clinical features (Orphanet curated; top 45 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000822 | Hypertension | Frequent (30-79%) |
| HP:0001635 | Congestive heart failure | Frequent (30-79%) |
| HP:0001644 | Dilated cardiomyopathy | Frequent (30-79%) |
| HP:0001649 | Tachycardia | Frequent (30-79%) |
| HP:0001712 | Left ventricular hypertrophy | Frequent (30-79%) |
| HP:0001962 | Palpitations | Frequent (30-79%) |
| HP:0002094 | Dyspnea | Frequent (30-79%) |
| HP:0002875 | Exertional dyspnea | Frequent (30-79%) |
| HP:0005135 | Abnormal T-wave | Frequent (30-79%) |
| HP:0010741 | Pedal edema | Frequent (30-79%) |
| HP:0011703 | Sinus tachycardia | Frequent (30-79%) |
| HP:0012378 | Fatigue | Frequent (30-79%) |
| HP:0012664 | Reduced left ventricular ejection fraction | Frequent (30-79%) |
| HP:0012764 | Orthopnea | Frequent (30-79%) |
| HP:0025169 | Left ventricular systolic dysfunction | Frequent (30-79%) |
| HP:0030848 | Elevated jugular venous pressure | Frequent (30-79%) |
| HP:0001653 | Mitral regurgitation | Occasional (5-29%) |
| HP:0001708 | Right ventricular failure | Occasional (5-29%) |
| HP:0001907 | Thromboembolism | Occasional (5-29%) |
| HP:0002092 | Pulmonary arterial hypertension | Occasional (5-29%) |
| HP:0004756 | Ventricular tachycardia | Occasional (5-29%) |
| HP:0005120 | Abnormal cardiac atrium morphology | Occasional (5-29%) |
| HP:0005133 | Right ventricular dilatation | Occasional (5-29%) |
| HP:0006705 | Abnormal atrioventricular valve morphology | Occasional (5-29%) |
| HP:0012398 | Peripheral edema | Occasional (5-29%) |
| HP:0012763 | Paroxysmal dyspnea | Occasional (5-29%) |
| HP:0012819 | Myocarditis | Occasional (5-29%) |
| HP:0030148 | Heart murmur | Occasional (5-29%) |
| HP:0030356 | Increased serum interferon-gamma level | Occasional (5-29%) |
| HP:0030830 | Crackles | Occasional (5-29%) |
| HP:0031295 | Left atrial enlargement | Occasional (5-29%) |
| HP:0100602 | Preeclampsia | Occasional (5-29%) |
| HP:0100603 | Toxemia of pregnancy | Occasional (5-29%) |
| HP:0100749 | Chest pain | Occasional (5-29%) |
| HP:0000819 | Diabetes mellitus | Very rare (<1-4%) |
| HP:0001513 | Obesity | Very rare (<1-4%) |
| HP:0001903 | Anemia | Very rare (<1-4%) |
| HP:0002027 | Abdominal pain | Very rare (<1-4%) |
| HP:0002099 | Asthma | Very rare (<1-4%) |
| HP:0002401 | Stroke-like episode | Very rare (<1-4%) |
| HP:0002878 | Respiratory failure | Very rare (<1-4%) |
| HP:0002926 | Abnormality of thyroid physiology | Very rare (<1-4%) |
| HP:0002960 | Autoimmunity | Very rare (<1-4%) |
| HP:0011713 | Left bundle branch block | Very rare (<1-4%) |
| HP:0030149 | Cardiogenic shock | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | peripartum cardiomyopathy |
| Mondo ID | MONDO:0018920 |
| EFO | EFO:0002628 |
| Orphanet | 563 |
| DOID | DOID:9997 |
| ICD-10-CM | O90.3 |
| ICD-11 | 1218807936 |
| NCIT | C171602 |
| SNOMED CT | 62377009 |
| UMLS | C0877208 |
| MedGen | 163756 |
| GARD | 0000220 |
| MedDRA | 10049430 |
| Is cancer (heuristic) | no |
Also known as: Meadows’ syndrome · peripartum cardiomyopathy · postpartum cardiomyopathy
Data availability: 4 cell lines.
Disease family
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › muscle tissue disorder › cardiomyopathy › intrinsic cardiomyopathy › dilated cardiomyopathy › non-familial dilated cardiomyopathy › peripartum cardiomyopathy
Related subtypes (1): cirrhotic cardiomyopathy
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Bromocriptine | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Sodium Chloride.
Clinical trials & evidence
Clinical trials
Clinical trials: 12.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 8 |
| PHASE4 | 1 |
| PHASE3 | 1 |
| PHASE2/PHASE3 | 1 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03081949 | PHASE4 | COMPLETED | Peripartum Cardiomyopathy in Nigeria Registry |
| NCT02590601 | PHASE3 | WITHDRAWN | Bromocriptine in the Treatment of Peripartum Cardiomyopathy |
| NCT03907267 | PHASE2/PHASE3 | COMPLETED | Taurine in Peripartum Cardiomyopathy |
| NCT00998556 | PHASE2 | COMPLETED | Effect of Bromocriptine on Left Ventricular Function in Women With Peripartum Cardiomyopathy |
| NCT06607471 | Not specified | RECRUITING | Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study. |
| NCT03364140 | Not specified | UNKNOWN | A Registry of Peripartum Cardiomyopathy in Turkey |
| NCT04049136 | Not specified | COMPLETED | NT-proBNP Levels and Obesity in Pregnancy |
| NCT04143997 | Not specified | WITHDRAWN | Diastolic Dysfunction PPCM in Patients With Documented Left Ventricular Systolic Function Recovery |
| NCT04144660 | Not specified | COMPLETED | Treatment Use of ECMO In Pregnancy or Peripartum Patient. |
| NCT04234659 | Not specified | COMPLETED | PPCM Observational Study (Peripartum Cardiomyopathy) |
| NCT04927715 | Not specified | UNKNOWN | Irisin Expression and Gene Polymorphism With Peripartum Cardiomyopathy. |
| NCT05878041 | Not specified | UNKNOWN | Creation of a Multicenter National Registry for Peripartum Cardiomyopathy. |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BROMOCRIPTINE | 4 | 6 |
| SODIUM CHLORIDE | 4 | 1 |
| SODIUM SELENATE | 3 | 1 |
| SODIUM SELENITE | 3 | 1 |
| TAURINE | 3 | 1 |
| CHEMBL1625141 | 0 | 2 |
| CHEMBL4206476 | 0 | 2 |
| CHEMBL4206925 | 0 | 2 |