Periprosthetic joint infection
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Summary
Periprosthetic joint infection (MONDO:0800179) is a disease and 29 clinical trials. Top therapeutic interventions include povidone-iodine, chlorhexidine gluconate, and vancomycin. A subtype of bacterial arthritis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 29
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | periprosthetic joint infection |
| Mondo ID | MONDO:0800179 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of bacterial arthritis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › bacterial arthritis › periprosthetic joint infection
Related subtypes (5): gonococcal infection of joint, staphylococcus discitis, escherichia coli discitis, streptococcus pneumoniae discitis, salmonella discitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 29.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 22 |
| PHASE3 | 2 |
| PHASE2 | 2 |
| PHASE1/PHASE2 | 2 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06126614 | PHASE3 | RECRUITING | Infection Prophylaxis in Total Joint Replacement |
| NCT05084378 | PHASE3 | COMPLETED | Evaluation of Emerging New Treatments for Infection Prevention in Total Joint Replacement |
| NCT06428448 | PHASE2 | RECRUITING | Study to Evaluate the REMEDY SPECTRUM GV IM Spacer Nail in the Treatment of Ankle-Related Infections |
| NCT06889701 | PHASE1/PHASE2 | RECRUITING | A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in PJI Participants |
| NCT06942624 | PHASE1/PHASE2 | NOT_YET_RECRUITING | Phage Therapy for the Treatment of a Chronic Enterococcus Faecium Periprosthetic Joint Infection |
| NCT07599865 | PHASE2 | NOT_YET_RECRUITING | Periprosthetic Joint Infection Bubble Study |
| NCT06827041 | PHASE1 | ACTIVE_NOT_RECRUITING | Use of Phage Therapy for Treatment of a Periprosthetic Joint Infection |
| NCT05159739 | Not specified | ENROLLING_BY_INVITATION | Genetic Susceptibility to Periprosthetic Joint Infections |
| NCT05284318 | Not specified | RECRUITING | Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI. |
| NCT05361941 | Not specified | RECRUITING | Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth In/near Infected Bone Cavities |
| NCT05640336 | Not specified | ENROLLING_BY_INVITATION | Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression |
| NCT06189885 | Not specified | NOT_YET_RECRUITING | Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial |
| NCT06268795 | Not specified | RECRUITING | A Diagnostic Test Accuracy Study Comparing Biopsy to Aspiration in Shoulder and Elbow Arthroplasty Revision Surgery (BASE Study) |
| NCT06440564 | Not specified | ENROLLING_BY_INVITATION | Laser Disinfection in Periprosthetic Joint Infection |
| NCT06464770 | Not specified | RECRUITING | Optimizing Infection Prophylaxis Prior to Shoulder Surgery |
| NCT06804265 | Not specified | RECRUITING | Molecular Biology in the Identification of Pathogens at Reimplantation in the Two-Stage Treatment of Periprosthetic Infections |
| NCT07313215 | Not specified | RECRUITING | Rifampin-combined Antibiotic Therapy for Staphylococcal PJI |
| NCT07358455 | Not specified | NOT_YET_RECRUITING | Preop Biomarkers as Outcome Predictors in 2 Stage Revision Surgery for PJI |
| NCT07494630 | Not specified | ACTIVE_NOT_RECRUITING | Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing. |
| NCT02530229 | Not specified | UNKNOWN | Arthrocentesis Study |
| NCT02868736 | Not specified | UNKNOWN | Clinical Validation of CD Diagnostics Synovasure PJI ELISA Test and Synovasure PJI Lateral Flow Test for Detection of Periprosthetic Joint Infection in Synovial Fluid |
| NCT03139539 | Not specified | COMPLETED | Intraoperative Microbial Contamination |
| NCT04274517 | Not specified | TERMINATED | Microbial Growth in Operative Splash Basins During Total Joint Arthroplasty |
| NCT04583241 | Not specified | TERMINATED | Prospective Study of Patients Treated for Bone and Joint Infection (BJI) Due to Staphylococcus Aureus, Aiming at Identifying Biomarkers of Diagnosis Interest in Chronic BJI |
| NCT05117671 | Not specified | COMPLETED | Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice? |
| NCT05320354 | Not specified | UNKNOWN | Diagnosis and Bacterial Identification of Periprosthetic Joint Infection With Microbial-ID |
| NCT05357287 | Not specified | UNKNOWN | Closed Incisional Negative Pressure Wound Therapy in Post-surgical Wound Care of Patients With Periprosthetic Joint Infection |
| NCT05495815 | Not specified | WITHDRAWN | Proper Duration of Suppressive Antibiotic Therapy After Debridement, Antibiotics, and Implant Retention |
| NCT07232771 | Not specified | COMPLETED | Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| POVIDONE-IODINE | 4 | 2 |
| CHLORHEXIDINE GLUCONATE | 4 | 1 |
| VANCOMYCIN | 4 | 1 |
| RIFAQUIZINONE | 2 | 1 |
| CHEMBL1628 | 0 | 2 |
| CHEMBL3747636 | 0 | 1 |
| 17 | 0 | 1 |