Peritoneal carcinomatosis
disease diseaseOn this page
Also known as abdominal carcinomatosiscarcinomatosis of the peritoneum
Summary
Peritoneal carcinomatosis (MONDO:0700336) is a disease and 120 clinical trials. Top therapeutic interventions include paclitaxel, indocyanine green acid form, and sodium thiosulfate. A subtype of peritoneum cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 120
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | peritoneal carcinomatosis |
| Mondo ID | MONDO:0700336 |
| ICD-11 | 1523083931 |
| NCIT | C27382 |
| UMLS | C0346990 |
| MedGen | 577752 |
| Is cancer (heuristic) | no |
Also known as: abdominal carcinomatosis · carcinomatosis of the peritoneum · peritoneal carcinomatosis
Disease family
This is a subtype of peritoneum cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › peritoneum cancer › peritoneal carcinomatosis
Related subtypes (5): round ligament malignant neoplasm, peritoneal carcinoma, malignant peritoneal solitary fibrous tumor, malignant peritoneal mesothelioma, malignant peritoneal germ cell tumor
Subtypes (1): pseudomyxoma peritonei
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 120.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 46 |
| PHASE2 | 36 |
| PHASE1 | 21 |
| PHASE1/PHASE2 | 8 |
| PHASE2/PHASE3 | 3 |
| PHASE3 | 3 |
| EARLY_PHASE1 | 2 |
| PHASE4 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05250648 | PHASE4 | RECRUITING | Clinical Trial on HIPEC With Mitomycin C in Colon Cancer Peritoneal Metastases (GECOP-MMC) |
| NCT02758951 | PHASE2/PHASE3 | ACTIVE_NOT_RECRUITING | Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases |
| NCT03348150 | PHASE3 | ACTIVE_NOT_RECRUITING | Gastrectomy + Cytoreductive Surgery + HIPEC for Gastric Cancer With Peritoneal Dissemination. |
| NCT07001748 | PHASE2/PHASE3 | RECRUITING | Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity |
| NCT01683864 | PHASE2/PHASE3 | TERMINATED | Randomized Controlled Trial to Prevent Peritoneal Seeding in Gastric Cancer |
| NCT02840331 | PHASE3 | UNKNOWN | Pilot Study on Intra-abdominal Photodynamic Diagnosis in Peritoneal Carcinosis |
| NCT03179579 | PHASE3 | UNKNOWN | Efficacy of HIPEC Combined With Systemic Chemotherapy and CRS on Peritoneal Metastases From Gastric Cancer |
| NCT03127774 | PHASE2 | ACTIVE_NOT_RECRUITING | Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma |
| NCT03280511 | PHASE2 | RECRUITING | Adjuvant Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in Resected High Risk Colon Cancer Patients |
| NCT04107077 | PHASE2 | RECRUITING | Phase II Study of the Effects of Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Gastric Cancer |
| NCT04762953 | PHASE2 | ACTIVE_NOT_RECRUITING | Study of Sequential Systemic Therapy + Intraperitoneal Paclitaxel in Gastric/GEJ Peritoneal Carcinomatosis |
| NCT04779554 | PHASE2 | RECRUITING | Flat Dose vs. Weight-based IP Chemotherapy for CRS/HIPEC |
| NCT04840264 | PHASE2 | RECRUITING | Docetaxel, Oxaliplatin and 5-FU for Gastric Cancer With Inoperable Malignant Bowel Obstruction |
| NCT05700656 | PHASE1/PHASE2 | RECRUITING | Galunisertib Combined With Capecitabine in Advanced CRC With PM |
| NCT05913674 | PHASE2 | RECRUITING | Technical Feasibility of Modified Early Post-Operative Intraperitoneal Chemotherapy (mEPIC) |
| NCT06504147 | PHASE2 | RECRUITING | A Study of Radspherin® in Patients With Primary Advanced Epithelial Cancer, With Peritoneal Metastasis That Are Homologous Recombination Proficient Scheduled to Undergo Neoadjuvant Chemotherapy and Interval Debulking Surgery |
| NCT07282834 | PHASE2 | RECRUITING | Heated Versus Aerosol-based Laparoscopic Chemotherapy for Cancer That Has Spread to the Peritoneum (Abdominal Lining) |
| NCT07514494 | PHASE2 | RECRUITING | Intensification Treatment of Ovarian Cancer by PIPAC |
| NCT07593261 | PHASE2 | NOT_YET_RECRUITING | MRI-Guided Adaptive Radiotherapy for Limited Peritoneal Metastases (MARACAS Trial). |
| NCT01095523 | PHASE2 | WITHDRAWN | Prospective Randomized Trial Evaluating Mandatory Second Look Surgery With HIPEC and CRS vs. Standard of Care in Subjects at High Risk of Developing Colorectal Peritoneal Metastases |
| NCT01116791 | PHASE2 | TERMINATED | Cytoreductive Surgery(CRS) Plus Hyperthermic Intraoperative Peritoneal Chemotherapy(HIPC) With Cisplatin to Treat Peritoneal Carcinomatosis From Upper Gastrointestinal Cancer |
| NCT01342653 | PHASE2 | SUSPENDED | Clinical Trial at Neoadjuvant Peritoneal and Systemic Chemotherapy Plus HIPEC in Gastric Carcinomatosis |
| NCT01379482 | PHASE2 | COMPLETED | Neo-adjuvant Chemo + Peritonectomy + Hyperthermic Intraperitoneal Chemo in Peritoneal Carcinomatosis From Gastric Cancer |
| NCT01443260 | PHASE1/PHASE2 | COMPLETED | A Study of GL-ONC1, an Oncolytic Vaccinia Virus, in Patients With Advanced Peritoneal Carcinomatosis |
| NCT01540344 | PHASE2 | TERMINATED | Combined Anticancer Treatment of Advanced Colon Cancer |
| NCT01575730 | PHASE2 | COMPLETED | Cytoreduction Followed by Normothermic Versus Hyperthermic Intraperitoneal Intraoperative Chemoperfusion (HIPEC): a Study in Peritoneal Carcinomatosis |
| NCT01833832 | PHASE2 | COMPLETED | Surgery and Heated Chemotherapy for Adrenocortical Carcinoma |
| NCT01834469 | PHASE1/PHASE2 | COMPLETED | Imaging of Peritoneal Carcinomatosis From Ovarian Carcinoma Patients |
| NCT02032485 | PHASE2 | COMPLETED | Near-Infrared Imaging of Peritoneal Carcinomatosis From Colorectal Cancer |
| NCT02040142 | PHASE2 | COMPLETED | HIPEC for Peritoneal Carcinomatosis |
| NCT02151448 | PHASE1/PHASE2 | COMPLETED | αDC1 Vaccine + Chemokine Modulatory Regimen (CKM) as Adjuvant Treatment of Peritoneal Surface Malignancies |
| NCT02320448 | PHASE2 | COMPLETED | Treating Peritoneal Carcinomatosis With PIPAC |
| NCT02604784 | PHASE1/PHASE2 | COMPLETED | Study of Efficacy and Safety of Laparoscopic Intra-abdominal Chemotherapy (PIPAC) Performed in Patients With Peritoneal Carcinomatosis From Colorectal, Ovarian, Gastric Cancer and Primary Peritoneal Tumors |
| NCT02739698 | PHASE2 | COMPLETED | Role of Intraperitoneal Intraoperative Chemotherapy With Paclitaxel in the Surgical Treatment of Peritoneal Carcinomatosis From Ovarian Cancer. Hyperthermia Versus Normothermia |
| NCT02759588 | PHASE1/PHASE2 | COMPLETED | GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent or Refractory Ovarian Cancer |
| NCT02891447 | PHASE2 | COMPLETED | Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer |
| NCT03150628 | PHASE2 | TERMINATED | Cytoreductive Surgery and Intraperitoneal Chemotherapy for Stomach CAncer: a Feasibility Study |
| NCT03246321 | PHASE2 | COMPLETED | PIPAC for Peritoneal Metastases of Colorectal Cancer |
| NCT03618758 | PHASE1/PHASE2 | COMPLETED | Intraperitoneal Paclitaxel Plus Systemic mFOLFOX6 |
| NCT03699332 | PHASE1/PHASE2 | UNKNOWN | Multi-modality Imaging in Peritoneal Carcinomatosis of Colorectal Origin |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PACLITAXEL | 4 | 8 |
| INDOCYANINE GREEN ACID FORM | 4 | 4 |
| SODIUM THIOSULFATE | 4 | 3 |
| INTERFERON ALFA-2B | 4 | 1 |
| PASIREOTIDE | 4 | 1 |
| VELIPARIB | 3 | 2 |
| OLVIMULOGENE NANIVACIREPVEC | 3 | 1 |
| RINTATOLIMOD | 3 | 1 |
| ST. JOHN’S WORT | 3 | 1 |
| EFTILAGIMOD ALFA | 2 | 1 |
| PEGSITACIANINE | 2 | 1 |
| CHEMBL3753202 | 0 | 3 |
| CHEMBL4071382 | 0 | 3 |
| CHEMBL5175144 | 0 | 3 |
| CHEMBL454299 | 0 | 1 |