persistent polyclonal B-cell lymphocytosis

Summary

persistent polyclonal B-cell lymphocytosis (MONDO:0011672) is a disease and 1 clinical trial. A subtype of lymphoid hemopathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]
• Clinical trials: 1

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		154	Worldwide	Validated
Point prevalence	<1 / 1 000 000		Worldwide	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	persistent polyclonal B-cell lymphocytosis
Mondo ID	MONDO:0011672
MeSH	C564707
OMIM	606445
Orphanet	300324
SNOMED CT	763864008
UMLS	C1847973
MedGen	341117
GARD	0017366
Is cancer (heuristic)	no

Also known as: persistent polyclonal B-cell lymphocytosis · persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes · PPBL

Disease family

This is a subtype of lymphoid hemopathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › hematopoietic and lymphoid system neoplasm › lymphoid hemopathy › persistent polyclonal B-cell lymphocytosis

Related subtypes (3): lymphoma, histiocytic and dendritic cell neoplasm, immunodeficiency-associated lymphoproliferative disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03296046	Not specified	COMPLETED	Epidemiologic Study of Persistent Polyclonal B-cell Lymphocytosis (PPBL)