◎ Sugi Atlas

Atlas / Disease / Personality disorder

Personality disorder

disease
On this page

Also known as personality disorder (disease)

Summary

Personality disorder (MONDO:0002028) is a disease (an umbrella term covering 10 Mondo subtypes) and 83 clinical trials. Top therapeutic interventions include fluoxetine, guanfacine, and desipramine. A subtype of psychiatric disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Umbrella term: 10 Mondo subtypes
  • Clinical trials: 83

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namepersonality disorder
Mondo IDMONDO:0002028
DOIDDOID:1510
ICD-11941859884
NCITC34922
SNOMED CT33449004
UMLSC0031212
MedGen45827
Is cancer (heuristic)no

Also known as: personality disorder · personality disorder (disease)

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of psychiatric disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › personality disorder

Related subtypes (13): sexual disorder, dissociative disorder, impulse control disorder, cognitive disorder, factitious disorder, substance-related disorder, somatoform disorder, mental disorder, eating disorder, enuresis, Alice in Wonderland syndrome, catatonia, body integrity dysphoria

Subtypes (10): schizotypal personality disorder, borderline personality disorder, dependent personality disorder, obsessive-compulsive personality disorder, schizoid personality disorder, paranoid personality disorder, antisocial personality disorder, avoidant personality disorder, narcissistic personality disorder, histrionic personality disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 83.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified74
PHASE42
PHASE1/PHASE22
PHASE12
PHASE2/PHASE31
PHASE31
PHASE21

Top trials by phase / activity

NCTPhaseStatusTitle
NCT00353379PHASE4TERMINATEDPharmacology of Cognition in Schizotypal Personality Disorder
NCT01182012PHASE4UNKNOWNReduction of Cardiovascular Risk in Severe Mental Illness
NCT00423462PHASE2/PHASE3COMPLETEDFirst Experimental Study of Transference-Interpretations (FEST)
NCT02751632PHASE3COMPLETEDThe Staged Treatment in Early Psychosis Study
NCT00291031PHASE1/PHASE2COMPLETEDStudy of the Effect of Imagery Rehearsal Therapy (IRT) of Nightmares
NCT00521417PHASE2UNKNOWNShort- and Long-term Group Psychotherapy
NCT00980824PHASE1/PHASE2UNKNOWNENGAGE - Meeting Mental Health Needs of Complex Comorbid Patients
NCT06993662PHASE1ACTIVE_NOT_RECRUITINGThe Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective.
NCT00400933PHASE1TERMINATEDEvaluation of a Six-session Psycho-education Group Program
NCT04822987Not specifiedACTIVE_NOT_RECRUITINGFactors Predicting Outcome in Group Treatment of Alcohol Use Disorders (AUDs)
NCT05074732Not specifiedRECRUITINGDundrum Forensic Redevelopment Evaluation Study: D-FOREST Study.
NCT05157386Not specifiedACTIVE_NOT_RECRUITINGPhysical Exercise as Adjunctive Therapy for Affective Disorder and Anxiety
NCT06115200Not specifiedNOT_YET_RECRUITINGNorwegian Adult Mental Health Registry
NCT06182787Not specifiedRECRUITINGDevelopment of a Model for Digital Monitoring of the Mental State of the Hospitalized Patient
NCT06415812Not specifiedRECRUITINGEvolutionary Systems Therapy for Personality Pathology
NCT06471010Not specifiedACTIVE_NOT_RECRUITINGB-DIT Feasibility Study
NCT06591754Not specifiedENROLLING_BY_INVITATIONFeasibility, Acceptability, and Preliminary Effects of ISTDP for Personality Disorders in a Specialized Psychiatric Clinic
NCT06592963Not specifiedRECRUITINGUnfolding Severe and Enduring Eating Disorders (U-SEED)
NCT06623838Not specifiedRECRUITINGAn Evolutionarily Informed Conceptualization of Personality Pathology
NCT06693089Not specifiedACTIVE_NOT_RECRUITINGMetacognitive Interpersonal Therapy Across Transdiagnostic Eating Disorders, Including Underweight
NCT06789380Not specifiedRECRUITINGThe (Cost-)Effectiveness of Generalist Versus Specialist Treatment for Severe Personality Disorders'
NCT06804369Not specifiedACTIVE_NOT_RECRUITINGBenchmarking and Change Mechanisms in Personality Disorder Treatment
NCT06839950Not specifiedRECRUITINGSensory Profile and Early Clinical Signs of Calm Room Users
NCT06863909Not specifiedENROLLING_BY_INVITATIONStudy on the Effectiveness of Journaling as an add-on to Cognitive Behavioral Therapy
NCT06913738Not specifiedRECRUITINGEvaluation of a Dimensional Adaptation of Good Psychiatric Management (GPM-extended) for the Treatment of Borderline Personality Disorder
NCT06983002Not specifiedNOT_YET_RECRUITINGBridging Affect Consciousness, Mentalization and Trauma- Exploring an Integrative Treatment Approach for Personality Disorder (PD).
NCT07017543Not specifiedACTIVE_NOT_RECRUITINGDynamics of Psychotherapy and Treatment Outcomes
NCT07078227Not specifiedRECRUITINGLong-term Follow-up of Depressive Disorders in Psychiatric Care
NCT07082777Not specifiedRECRUITINGRecovery in Telling Life Stories
NCT07342270Not specifiedNOT_YET_RECRUITINGSensorimotor Psychotherapy for Personality Disorders
NCT07398365Not specifiedRECRUITINGMedical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients
NCT00000376Not specifiedCOMPLETEDCognitive and Drug Therapy for Drug-Resistant Depression
NCT00137189Not specifiedCOMPLETEDResource-oriented Music Therapy for Psychiatric Patients With Low Therapy Motivation
NCT00153959Not specifiedCOMPLETEDPsychiatric Day Hospital Treatment
NCT00184301Not specifiedCOMPLETEDA Comparison Study of Treatments Given to Patients With Concurrent Eating Disorder and Personality Disorder.
NCT00184418Not specifiedCOMPLETEDThe Immune System and Psychiatric Disorders
NCT00264069Not specifiedCOMPLETEDADH.E.R.E.: Therapeutic ADHerence and Treatment Strategies: A Mental Health Registry
NCT00378248Not specifiedUNKNOWNUllevål PersonalityProject
NCT00458094Not specifiedCOMPLETEDPeer Support for Increasing Physical Activity in People With Serious Mental Illnesses
NCT01070134Not specifiedUNKNOWNMindfulness-based Behavioural Therapy (MIBT) Versus Psychodynamic Therapy for Patients With Major Depressive Disorder in Psychotherapeutic Day Treatment. A Randomised Clinical Pilot Trial

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
FLUOXETINE43
GUANFACINE43
DESIPRAMINE41

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 21

This page pulls from 21 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogenccgwasgwas_studyhgncicd11medgenmeshmimmondomondochildmondoparentncitorphanetsctidumls