Physiological sexual disorder

Summary

Physiological sexual disorder (MONDO:0002134) is a disease and 226 clinical trials. Top therapeutic interventions include rosuvastatin, sildenafil, and goserelin. A subtype of reproductive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 226

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	physiological sexual disorder
Mondo ID	MONDO:0002134
MeSH	D012735
DOID	DOID:1876
UMLS	C0237873
MedGen	66756
Is cancer (heuristic)	no

Also known as: physiological sexual disorder · physiological sexual disorders · physiological sexual dysfunction · physiological sexual dysfunctions · Sex disorders · sexual disorder, physiological · sexual disorders, physiological · sexual dysfunction · sexual dysfunctions, physiological

Disease family

This is a subtype of reproductive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › physiological sexual disorder

Related subtypes (29): pelvic organ prolapse, cortisone reductase deficiency, gonadal disorder, female reproductive system disorder, male reproductive system disorder, pituitary gland disorder, infertility disorder, hypospadias, reproductive system neoplasm, dysplasia of cervix, female genital tuberculosis, habitual spontaneous abortion, aromatase excess syndrome, hand-foot-genital syndrome, mullerian duct anomalies-limb anomalies syndrome, Currarino triad, double uterus-hemivagina-renal agenesis syndrome, congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency, classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency, congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency, spondylocostal dysostosis-anal and genitourinary malformations syndrome, congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency, hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism, estrogen resistance syndrome, short stature, microcephaly, and endocrine dysfunction, diethylstilbestrol syndrome, sexually transmitted disease, NR5A1-related sex development disorder

Subtypes (1): erectile dysfunction

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 6 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Bremelanotide	Phase 3 (in late-stage trials)
Dapoxetine	Phase 3 (in late-stage trials)
Estradiol	Phase 3 (in late-stage trials)
Norethindrone	Phase 3 (in late-stage trials)
Prasterone	Phase 3 (in late-stage trials)
Tibolone	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Alprostadil, Buspirone, Ginkgo, Oxytocin, Sildenafil, Tadalafil, Testosterone Undecanoate.

Clinical trials & evidence

Clinical trials

Clinical trials: 226.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	179
PHASE4	21
PHASE3	15
PHASE2	4
PHASE2/PHASE3	3
PHASE1/PHASE2	2
PHASE1	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00174850	PHASE4	COMPLETED	Switching From an SSRI to Tiagabine(GABITRIL) in Order to Alleviate SSRI Induced Sexual Dysfunction
NCT00334048	PHASE4	COMPLETED	Treating Sexual Dysfunction From Selective Serotonin Reuptake Inhibitor (SSRI) Medication: a Study Comparing Requip CR to Placebo
NCT00375297	PHASE4	COMPLETED	Study of Sildenafil for Treatment of SSRI-Antidepressant Sexual Dysfunction in Women
NCT00377793	PHASE4	COMPLETED	Levitra (Vardenafil, BAY38-9456) Partner Satisfaction Study II
NCT00456820	PHASE4	COMPLETED	Wellbutrin XL Effects on SSRIs Induced Changes
NCT00923676	PHASE4	UNKNOWN	Treatment of Hyperlipidemia and Sexual Dysfunction
NCT01238705	PHASE4	UNKNOWN	Combined Antihypertensive Therapy and Sexual Dysfunction
NCT01312259	PHASE4	UNKNOWN	Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome
NCT01554735	PHASE4	COMPLETED	Effects of Lifestyle-modification Induced Weight Loss on Sexual and Urinary Function, and Quality of Life in Obese Men
NCT01554865	PHASE4	COMPLETED	Effects of Diet-induced Weight Loss in Obese Men
NCT01642576	PHASE4	COMPLETED	Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men
NCT01742390	PHASE4	UNKNOWN	A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders
NCT01856127	PHASE4	TERMINATED	Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?
NCT02472652	PHASE4	TERMINATED	Aripiprazole, Abilify Maintena Collaborative Clinical Protocol
NCT02554045	PHASE4	COMPLETED	Daily Tadalafil on Body Fat and Lean Mass
NCT02612714	PHASE4	COMPLETED	Statin Lowering Testosterone and Sexual Function
NCT03801031	PHASE4	TERMINATED	Sexual Dysfunction in Gynecologic Oncology Patients
NCT04560283	PHASE4	COMPLETED	HYDEAL-D® Application for Promoting the Restoration of Sexual Function in the Postpartum Period
NCT05317364	PHASE4	TERMINATED	Topical Vaginal Estrogen for Postpartum Obstetric Anal Sphincter Injury Recovery
NCT05484167	PHASE4	WITHDRAWN	Natesto Testosterone Nasal Gel for Hypogonadal Men
NCT06031493	PHASE4	UNKNOWN	A Multimodal Intervention Program to Improve Sexual Health and Self-perceived Quality of Life in Patients Treated for Cervical Cancer (PROVIDENCE)
NCT00070733	PHASE3	UNKNOWN	The Effect of 5-Alpha Reductase on Testosterone in Men
NCT00075855	PHASE3	COMPLETED	Low-Dose Testosterone in Improving Libido in Postmenopausal Female Cancer Survivors
NCT00181961	PHASE3	COMPLETED	Safety and Effectiveness Study of Maca Root to Treat Antidepressant-Induced Sexual Dysfunction
NCT00210613	PHASE3	COMPLETED	A Study of Withdrawal Effects With Dapoxetine in the Treatment of Premature Ejaculation
NCT00413764	PHASE3	COMPLETED	Efficacy of Tibolone Versus Transdermal E2/NETA on Sexual Function in Naturally Postmenopausal Women (P06089)
NCT00541047	PHASE3	COMPLETED	RADICALS - Radiotherapy and Androgen Deprivation In Combination After Local Surgery
NCT00575328	PHASE3	TERMINATED	Study of Maca Root to Treat Sexual Dysfunction Associated With the Treatment Regimen for Bipolar Disorder in Females
NCT00632138	PHASE3	COMPLETED	Pelvic Floor Muscle Training and Biofeedback or Standard Therapy in Men Who Have Undergone Radical Prostatectomy or Transurethral Resection of the Prostate
NCT00652262	PHASE3	COMPLETED	BAY38-9456 - Supportive Trial for Spinal Injury
NCT00931528	PHASE3	COMPLETED	Tadalafil in Preventing Erectile Dysfunction in Patients With Prostate Cancer Treated With Radiation Therapy
NCT00981305	PHASE3	COMPLETED	Impact of Lactate-Containing Vaginal Lubricant on Sexual Dysfunction in Young Breast Cancer Survivors
NCT01063855	PHASE3	COMPLETED	Concomitant Use of PriLigy in Men Treated for Erectile Dysfunction
NCT01230762	PHASE3	COMPLETED	An Open-Label Study of the Long-Term Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation
NCT01573442	PHASE3	COMPLETED	Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment
NCT02091765	PHASE3	COMPLETED	RCT of an Internet-based CBT Program for Sexuality and Intimacy Problems in Women Treated for Breast Cancer
NCT03102762	PHASE2/PHASE3	COMPLETED	Botulinum Toxin for Erectile Dysfunction
NCT05266651	PHASE2/PHASE3	UNKNOWN	Efficiency of Tadalafil for Management of Female Sexual Dysfunction
NCT06176820	PHASE2/PHASE3	UNKNOWN	Vaginal Hyaluronic Acid, Arginine and Liposome Gel Versus Vaginal Lubricant in Postmenopausal Women With Genitourinary Syndrome of Menopause
NCT04684602	PHASE1/PHASE2	RECRUITING	Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ROSUVASTATIN	4	4
SILDENAFIL	4	4
GOSERELIN	4	3
LEUPROLIDE	4	3
ROPINIROLE	4	3
TADALAFIL	4	3
VILAZODONE	4	3
ARIPIPRAZOLE	4	2
TESTOSTERONE	4	2
BICALUTAMIDE	4	1
BUPROPION HYDROCHLORIDE	4	1
DUTASTERIDE	4	1
DYDROGESTERONE	4	1
ESTRADIOL	4	1
ESTRIOL	4	1
FENOFIBRATE	4	1
SERTRALINE	4	1
TALAZOPARIB	4	1
TESTOSTERONE ENANTHATE	4	1
TIBOLONE	4	1
TRAZODONE	4	1
DAPOXETINE	3	4
AB-101	2	1
FISPEMIFENE	2	1
ISOXSUPRINE	2	1
CHEMBL139521	0	3
CHEMBL177542	0	3
CHEMBL4244897	0	3
CHEMBL1357356	0	2
CHEMBL4746472	0	2