Pineal region immature teratoma

Summary

Pineal region immature teratoma (MONDO:0004017) is a disease and 1 clinical trial. Top therapeutic interventions include ifosfamide. A subtype of malignant pineal area germ cell neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	pineal region immature teratoma
Mondo ID	MONDO:0004017
DOID	DOID:6858
NCIT	C6755
UMLS	C1335416
MedGen	277516
GARD	0023779
Anatomy (UBERON)	UBERON:0001905
Is cancer (heuristic)	no

Also known as: atypical pineal teratoma · immature teratoma of pineal area · immature teratoma of pineal region · immature teratoma of the pineal area · immature teratoma of the pineal region · pineal area immature teratoma

Disease family

This is a subtype of malignant pineal area germ cell neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › central nervous system neoplasm › central nervous system germ cell tumor › malignant pineal area germ cell neoplasm › pineal region immature teratoma

Related subtypes (4): pineal region yolk sac tumor, pineal region dysgerminoma, pineal region choriocarcinoma, pineal region germinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04684368	PHASE2	RECRUITING	A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
IFOSFAMIDE	4	1