Pineocytoma

Summary

Pineocytoma (MONDO:0016723) is a disease and 1 clinical trial. Top therapeutic interventions include perillyl alcohol. A subtype of benign endocrine neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Phenotypes (HPO): 13
• Clinical trials: 1

Clinical features

Signs & symptoms

Clinical features (HPO)

13 HPO clinical features (Orphanet curated; top 13 by frequency):

HPO ID	Term	Frequency
HP:0000238	Hydrocephalus	Very frequent (80-99%)
HP:0002017	Nausea and vomiting	Very frequent (80-99%)
HP:0002315	Headache	Very frequent (80-99%)
HP:0002354	Memory impairment	Very frequent (80-99%)
HP:0002516	Increased intracranial pressure	Very frequent (80-99%)
HP:0000492	Abnormal eyelid morphology	Frequent (30-79%)
HP:0000639	Nystagmus	Frequent (30-79%)
HP:0002131	Episodic ataxia	Frequent (30-79%)
HP:0002922	Increased CSF protein concentration	Frequent (30-79%)
HP:0030531	Altitudinal visual field defect	Frequent (30-79%)
HP:0100543	Cognitive impairment	Frequent (30-79%)
HP:0000364	Hearing abnormality	Occasional (5-29%)
HP:0001288	Gait disturbance	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	pineocytoma
Mondo ID	MONDO:0016723
EFO	EFO:1000476
Orphanet	251912
DOID	DOID:0081248
ICD-11	2055142333
NCIT	C6966
SNOMED CT	255045009
UMLS	C0917890
MedGen	183004
GARD	0008207
MedDRA	10035059
Is cancer (heuristic)	no

Also known as: benign pinealoma · pinealocytoma · pineocytoma · pineocytoma (disease) · Pineocytoma (WHO grade I) · pineocytoma, benign

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of benign endocrine neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › endocrine gland neoplasm › benign endocrine neoplasm › pineocytoma

Related subtypes (13): liver lipoma, liver hemangioma, bile duct papillary neoplasm, liver leiomyoma, benign carotid body paraganglioma, benign thyroid gland neoplasm, hepatocellular adenoma, benign neoplasm of pituitary gland, benign neoplasm of parathyroid gland, benign neoplasm of adrenal gland, benign neoplasm of thymus, TMEM127-related tumor predisposition, MAX-related tumor predisposition

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06357377	PHASE1	NOT_YET_RECRUITING	A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PERILLYL ALCOHOL	2	1