Pituicytoma

Summary

Pituicytoma (MONDO:0006372) is a disease. A subtype of pituitary cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 20

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		171	Worldwide	Validated
Point prevalence	<1 / 1 000 000		Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

20 HPO clinical features (Orphanet curated; top 20 by frequency):

HPO ID	Term	Frequency
HP:0011752	Neoplasm of the posterior pituitary	Obligate (100%)
HP:0011754	Pituicytoma	Obligate (100%)
HP:0012503	Abnormality of the pituitary gland	Very frequent (80-99%)
HP:0001123	Visual field defect	Frequent (30-79%)
HP:0002315	Headache	Frequent (30-79%)
HP:0000044	Hypogonadotropic hypogonadism	Occasional (5-29%)
HP:0000141	Amenorrhea	Occasional (5-29%)
HP:0000802	Impotence	Occasional (5-29%)
HP:0000824	Decreased response to growth hormone stimulation test	Occasional (5-29%)
HP:0000870	Increased circulating prolactin concentration	Occasional (5-29%)
HP:0002354	Memory impairment	Occasional (5-29%)
HP:0008214	Decreased serum estradiol	Occasional (5-29%)
HP:0008245	Pituitary hypothyroidism	Occasional (5-29%)
HP:0011043	Abnormality of circulating adrenocorticotropin level	Occasional (5-29%)
HP:0012378	Fatigue	Occasional (5-29%)
HP:0030018	Decreased female libido	Occasional (5-29%)
HP:0040075	Hypopituitarism	Occasional (5-29%)
HP:0040171	Decreased serum testosterone concentration	Occasional (5-29%)
HP:0000863	Central diabetes insipidus	Very rare (<1-4%)
HP:0100829	Galactorrhea	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	pituicytoma
Mondo ID	MONDO:0006372
EFO	EFO:1000477
Orphanet	251623
DOID	DOID:0081280
NCIT	C94524
SNOMED CT	608817003
UMLS	C2986550
MedGen	458776
GARD	0020711
Is cancer (heuristic)	no

Also known as: pituicytoma · pituicytoma (WHO grade I) · posterior pituitary astrocytoma · PTCY

Data availability: 1 cell line.

Disease family

This is a subtype of pituitary cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › musculoskeletal system cancer › bone cancer › skull cancer › pituitary cancer › pituicytoma

Related subtypes (3): growth hormone-producing pituitary gland carcinoma, pituitary adenocarcinoma, pituitary blastoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.