Pituitary cancer
diseaseOn this page
Also known as cancer of pituitary glandmalignant neoplasm of pituitarymalignant neoplasm of pituitary glandmalignant neoplasm of the pituitarymalignant neoplasm of the pituitary glandmalignant pituitary gland neoplasmmalignant pituitary gland tumormalignant pituitary gland tumourmalignant pituitary neoplasmmalignant pituitary tumormalignant pituitary tumourmalignant tumor of pituitarymalignant tumor of pituitary glandmalignant tumor of the pituitarymalignant tumor of the pituitary glandmalignant tumour of pituitarymalignant tumour of pituitary glandmalignant tumour of the pituitarymalignant tumour of the pituitary gland
Summary
Pituitary cancer (MONDO:0002109) is a cancer and 25 clinical trials. Top therapeutic interventions include cabergoline, corticorelin ovine triflutate, and hydrocortisone. A subtype of skull cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 25
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | pituitary cancer |
| Mondo ID | MONDO:0002109 |
| EFO | EFO:0005578 |
| DOID | DOID:1785 |
| ICD-10-CM | C75.1 |
| ICD-11 | 1130461249 |
| NCIT | C4769 |
| SNOMED CT | 363482009 |
| UMLS | C0496842 |
| MedGen | 96922 |
| GARD | 0023064 |
| Anatomy (UBERON) | UBERON:0000007 |
| Is cancer (heuristic) | yes |
Also known as: cancer of pituitary gland · malignant neoplasm of pituitary · malignant neoplasm of pituitary gland · malignant neoplasm of the pituitary · malignant neoplasm of the pituitary gland · malignant pituitary gland neoplasm · malignant pituitary gland tumor · malignant pituitary gland tumour · malignant pituitary neoplasm · malignant pituitary tumor · malignant pituitary tumour · malignant tumor of pituitary · malignant tumor of pituitary gland · malignant tumor of the pituitary · malignant tumor of the pituitary gland · malignant tumour of pituitary · malignant tumour of pituitary gland · malignant tumour of the pituitary · malignant tumour of the pituitary gland · pituitary cancer (+5 more)
Disease family
An umbrella term covering 4 Mondo subtypes.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › musculoskeletal system cancer › bone cancer › skull cancer › pituitary cancer
Related subtypes (5): jaw cancer, orbital cancer, skull base chordoma, malignant jugulotympanic paraganglioma, paranasal sinus cancer
Subtypes (4): growth hormone-producing pituitary gland carcinoma, pituicytoma, pituitary adenocarcinoma, pituitary blastoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 25.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 16 |
| PHASE2 | 3 |
| PHASE4 | 2 |
| EARLY_PHASE1 | 2 |
| PHASE3 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02190994 | PHASE4 | UNKNOWN | Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions |
| NCT02549768 | PHASE4 | UNKNOWN | Effect of Dexmedetomidine on Plasmatic Cortisol Response in Transsphenoidal Surgery |
| NCT02288962 | PHASE3 | ACTIVE_NOT_RECRUITING | Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas |
| NCT04042753 | PHASE2 | ACTIVE_NOT_RECRUITING | Nivolumab and Ipilimumab in People With Aggressive Pituitary Tumors |
| NCT00001860 | PHASE2 | COMPLETED | Sandostatin LAR Depot vs. Surgery for Treating Acromegaly |
| NCT00958841 | PHASE2 | TERMINATED | Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin |
| NCT02629549 | PHASE1 | TERMINATED | Intraoperative Imaging of Pituitary Adenomas by OTL |
| NCT07254104 | EARLY_PHASE1 | ENROLLING_BY_INVITATION | Clinical Evaluation of [68Ga]Ga-NOTA-RF PET Imaging Targeting RFVT3 in Patients With Pituitary Tumors |
| NCT01459237 | EARLY_PHASE1 | COMPLETED | Effects of Hormone Stimulation on Brain Scans for Cushing s Disease |
| NCT03382158 | Not specified | RECRUITING | International PPB/DICER1 Registry |
| NCT03665064 | Not specified | ACTIVE_NOT_RECRUITING | Long Term Outcome Study in Patients With Pituitary Disorders |
| NCT03678389 | Not specified | RECRUITING | Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery |
| NCT06282224 | Not specified | RECRUITING | Application of Augmented Reality Neuronavigation in Transnasal Endoscopic Skull Base Surgery |
| NCT06973824 | Not specified | RECRUITING | A Twenty-years’ Experience in Pituitary Disease. |
| NCT00001171 | Not specified | COMPLETED | Evaluation of Factors in Human Brain Tumors |
| NCT00001981 | Not specified | COMPLETED | The Treatment and Natural History of Acromegaly |
| NCT00005664 | Not specified | TERMINATED | Evaluation of Patients With Endocrine-Related Conditions |
| NCT01504399 | Not specified | COMPLETED | Rhinological Outcomes in Endonasal Pituitary Surgery |
| NCT01775332 | Not specified | UNKNOWN | Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools |
| NCT02632084 | Not specified | COMPLETED | Follow-up Evaluation of Photo-Dynamic Therapy for Pituitary Tumours |
| NCT02743442 | Not specified | TERMINATED | Da Vinci Transoral Robotic-assisted Surgery of Pituitary Gland |
| NCT05088252 | Not specified | COMPLETED | Desflurane and Anesthesia Recovery Period in Endonasal Endoscopic Pituitary Adenoma Resection |
| NCT05108064 | Not specified | UNKNOWN | Radiomic and Pathomic Study of Pituitary Adenoma Using Machine Learning |
| NCT06752824 | Not specified | COMPLETED | Analgesia Nociception Index (ANI) in Intracranial Surgical Anesthesia |
| NCT06826170 | Not specified | COMPLETED | Hypofractionated Radiosurgery to Treat Residual/Recurrent Non Secreting Pituitary Adenoma (HYPOADENO) |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CABERGOLINE | 4 | 1 |
| CORTICORELIN OVINE TRIFLUTATE | 4 | 1 |
| HYDROCORTISONE | 4 | 1 |
| PAFOLACIANINE | 4 | 1 |
| PREDNISONE | 4 | 1 |
| CHEMBL15720 | 0 | 1 |
| CHEMBL4593105 | 0 | 1 |
| CHEMBL5192470 | 0 | 1 |