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Atlas / Disease / Placenta accreta

Placenta accreta

disease
On this page

Also known as accreta, placentaIncreta, placentaPercreta, placentaplacenta Incretaplacenta Percreta

Summary

Placenta accreta (MONDO:0005916) is a disease and 86 clinical trials. Top therapeutic interventions include tranexamic acid and relaxin. A subtype of placenta disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 86

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical nameplacenta accreta
Mondo IDMONDO:0005916
EFOEFO:0007440
MeSHD010921
Orphanet662721
DOIDDOID:4744
ICD-10-CMO43.21
ICD-11298160226
NCITC26856
SNOMED CT70129008
UMLSC0032044
MedGen10780
GARD0027124
Is cancer (heuristic)no

Also known as: accreta, placenta · Increta, placenta · Percreta, placenta · placenta Increta · placenta Percreta

Disease family

This is a subtype of placenta disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › uterine disorder › placenta disorder › placenta accreta

Related subtypes (7): placental abruption, fetal growth restriction, oligohydramnios, placenta praevia, placental insufficiency, placenta neoplasm, disorder of extraembryonic membrane

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

DrugDevelopment status
Sodium ChloridePhase 3 (in late-stage trials)
Tranexamic AcidPhase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 86.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified82
PHASE42
PHASE31
PHASE2/PHASE31

Top trials by phase / activity

NCTPhaseStatusTitle
NCT02806024PHASE4COMPLETEDPerioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study
NCT05205304PHASE4UNKNOWNThe Role of Transdermal CO2 in MDA Level in Patient Underwent Abdominal Aortic Temporary Cross Clamp
NCT02329756PHASE3WITHDRAWNTranexamic Acid in Adherent Placenta (TAP)
NCT04609527PHASE2/PHASE3UNKNOWNManagement of Placenta Accreta Spectrum
NCT05139498Not specifiedACTIVE_NOT_RECRUITINGConservative Management for PAS Pilot
NCT05922397Not specifiedRECRUITINGPlacenta Accreta Spectrum Topographic Classification
NCT06185894Not specifiedRECRUITINGSingle-step Placenta Accreta Resective Technique Tourniqueted vs Absence, Conservative Uterine Surgery
NCT06465836Not specifiedRECRUITINGSimplified Conservative Measures in Managing Morbidly Adherent Placenta in Beni-Suef University
NCT06575023Not specifiedNOT_YET_RECRUITINGTamponade vs Partial Myometrial Resection of Lower Uterine Segment in Management of Placenta Accreta Spectrum Cases
NCT06712576Not specifiedNOT_YET_RECRUITINGEvaluation of Planned Conservative Surgical Management of Placenta Accreta Spectrum in Women’s Health Center, Assiut University Hospital
NCT06717997Not specifiedNOT_YET_RECRUITINGThe Placental Thickness and Pregnancy Outcomes in Placenta Previa Women
NCT06755047Not specifiedRECRUITING3D Placental Volume in Placenta Accreta
NCT06761885Not specifiedNOT_YET_RECRUITINGPrediction of Placenta Accreta Outcome in Pregnant Woman With Placenta Previa Using (hcg_h ) as Abiomarkers
NCT06833606Not specifiedRECRUITINGDiagnosis and Outcomes of Placental Accretism
NCT06957184Not specifiedNOT_YET_RECRUITINGA Comparison Between Bladder Dissection Before and After Uterine Incision During Cesarean Section for Placenta Accreta Spectrum: A Randomized Controlled Study
NCT07283042Not specifiedRECRUITINGEvaluation of Clinical Outcomes and Acceptability of an Anatomical Classification for Placenta Accreta Spectrum
NCT07452185Not specifiedNOT_YET_RECRUITINGEvaluation of Cervical Invasion and Length in Placenta Accreta Patients
NCT01289262Not specifiedCOMPLETEDLong Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure
NCT02010229Not specifiedCOMPLETEDClinical Situations at High Risk of Placenta Accreta / Percreta
NCT02302573Not specifiedCOMPLETEDPlacenta Accreta : Contrast-enhanced Ultrasound Analysis in High Risk Population
NCT02442518Not specifiedUNKNOWNAntenatal Diagnosis of Placental Attachment Disorders
NCT02635412Not specifiedWITHDRAWNDelivery Timing in Morbidly Adherent Placentas: a Randomized, Controlled Trial
NCT02702024Not specifiedCOMPLETEDThe Effectiveness of Double Incision Technique in Uterus Preserving Surgery for Placenta Percreta
NCT02712099Not specifiedCOMPLETEDTUI 3D in Diagnosis of Placenta Accreta: Comparison With Gray-scale and Color Doppler Techniques
NCT02728232Not specifiedCOMPLETEDInternal Iliac Artery Ligation and Abnormally Invasive Placenta
NCT02729974Not specifiedCOMPLETEDUse of ROTEM Intraoperatively in Women With Placenta Accreta
NCT02784886Not specifiedUNKNOWNCell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta
NCT02966197Not specifiedCOMPLETEDEfficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta
NCT03032770Not specifiedCOMPLETEDEarly Prediction of Placenta Accreta by Ultrasound and Color Doppler
NCT03129035Not specifiedUNKNOWNBilateral Internal Iliac Artery Ligation Before Cesarean Hysterectomy
NCT03224780Not specifiedUNKNOWNCreatine Kinase Versus 3D Doppler for Antenatal Diagnosis of Abnormal Adherent Placenta.
NCT03273569Not specifiedUNKNOWNPDIUC Protocol for Placental Accreta
NCT03286998Not specifiedUNKNOWNUltrasound in Prediction of Operative Findings in Cesarean Section Among Placenta Accreta Cases
NCT03327818Not specifiedCOMPLETEDComparison Between Hysterectomy and Conservative Management in Treatment of Placenta Accreta Regarding Maternal Complication
NCT03372538Not specifiedUNKNOWNMultidisciplinary Team in Management of Placenta Accreta
NCT03437291Not specifiedUNKNOWNComparison Between the Role of Transabdominal Ultrasound Versus Transvaginal Ultrasound in Evaluation of Placental Invasion in Cases of Placenta Previa Anterior Wall With Previous Uterine Scar
NCT03530475Not specifiedUNKNOWNDiagnostic Accuracy of Doppler Ultrasound and Role of Uterine Artery Doppler
NCT03638024Not specifiedUNKNOWNCell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion .
NCT03707132Not specifiedCOMPLETEDTourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta
NCT03763916Not specifiedUNKNOWNIntraoperative Ureteric Dissection vs Preoperative Ureteric Stenting in Women With Abnormally Invasive Placenta

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
TRANEXAMIC ACID41
RELAXIN31
CHEMBL475494901

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 23

This page pulls from 23 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogardgenccgwasgwas_studyhgncicd10cmicd11medgenmeshmimmondomondochildmondoparentncitorphanetsctidumls