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Atlas / Disease / Placental insufficiency

Placental insufficiency

disease
On this page

Also known as insufficiency, placentaluteroplacental vascular insufficiency

Summary

Placental insufficiency (MONDO:0005919) is a disease and 19 clinical trials. Top therapeutic interventions include aspirin and pravastatin. A subtype of placenta disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Prevalence: 1-5 / 10 000 (Worldwide) [Orphanet-validated]
  • Phenotypes (HPO): 20
  • Clinical trials: 19

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

TypeClassValueGeographyValidation
Point prevalence1-5 / 10 00033WorldwideValidated

Signs & symptoms

Clinical features (HPO)

20 HPO clinical features (Orphanet curated; top 20 by frequency):

HPO IDTermFrequency
HP:0100767Abnormality of the placentaObligate (100%)
HP:0001511Intrauterine growth retardationVery frequent (80-99%)
HP:0001518Small for gestational ageVery frequent (80-99%)
HP:0003508Proportionate short statureVery frequent (80-99%)
HP:0006266Small placentaVery frequent (80-99%)
HP:0011403Abnormal umbilical cord blood vesselsVery frequent (80-99%)
HP:0012418HypoxemiaVery frequent (80-99%)
HP:0000717AutismFrequent (30-79%)
HP:0000729Autistic behaviorFrequent (30-79%)
HP:0002725Systemic lupus erythematosusFrequent (30-79%)
HP:0003613Antiphospholipid antibody positivityFrequent (30-79%)
HP:0012759Neurodevelopmental abnormalityFrequent (30-79%)
HP:0000855Insulin resistanceOccasional (5-29%)
HP:0001627Abnormal heart morphologyOccasional (5-29%)
HP:0002088Abnormal lung morphologyOccasional (5-29%)
HP:0005268Spontaneous abortionOccasional (5-29%)
HP:0008071Maternal hypertensionOccasional (5-29%)
HP:0100021Cerebral palsyOccasional (5-29%)
HP:0100601EclampsiaOccasional (5-29%)
HP:0100602PreeclampsiaOccasional (5-29%)

Identifiers

Disease identifiers

FieldValue
Canonical nameplacental insufficiency
Mondo IDMONDO:0005919
EFOEFO:0007443
MeSHD010927
Orphanet439167
DOIDDOID:3891
SNOMED CT237292005
UMLSC0032051
MedGen45942
GARD0021823
Is cancer (heuristic)no

Also known as: insufficiency, placental · uteroplacental vascular insufficiency

Disease family

This is a subtype of placenta disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › uterine disorder › placenta disorder › placental insufficiency

Related subtypes (7): placental abruption, fetal growth restriction, oligohydramnios, placenta accreta, placenta praevia, placenta neoplasm, disorder of extraembryonic membrane

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Aspirin.

Clinical trials & evidence

Clinical trials

Clinical trials: 19.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified14
PHASE42
PHASE22
PHASE31

Top trials by phase / activity

NCTPhaseStatusTitle
NCT01352234PHASE4COMPLETEDComparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia
NCT03528967PHASE4COMPLETEDEnoxaparin in the Prevention of Placental Insufficiency in Pregnant Women
NCT01388322PHASE3COMPLETEDLow Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy
NCT07098975PHASE2RECRUITINGStatin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)
NCT01616615PHASE2COMPLETEDAspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation
NCT05423665Not specifiedRECRUITINGSpeckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth Twin Pregnancies
NCT06339606Not specifiedNOT_YET_RECRUITINGPregnancy Repository
NCT06861309Not specifiedRECRUITINGPlacental Imaging Techniques
NCT07144839Not specifiedRECRUITINGPlacental Risk Assessment to CusTomize Individualized Pregnancy Care and Evaluation
NCT00465634Not specifiedCOMPLETEDDoppler and Biological Second Trimester Placental Insufficiency Screening
NCT00930397Not specifiedCOMPLETEDObservational Study in UTERO - Placental 3D Doppler Examination: Interest for Pre-eclampsia Screening During Pregnancy
NCT01092949Not specifiedCOMPLETEDReference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE
NCT01736826Not specifiedCOMPLETEDFree DNA and Nucleosome Concentrations in Pathological Pregnancies
NCT02971566Not specifiedCOMPLETEDSplanchnic Oxygenation Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler.
NCT03100084Not specifiedUNKNOWNPREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome
NCT03731546Not specifiedCOMPLETEDEffect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency
NCT03731611Not specifiedCOMPLETEDImpact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency
NCT05381272Not specifiedUNKNOWNImpact of Early and Severe Fetal Growth Restriction on Neurodevelopmental Outcomes in Preterm Infants
NCT06039319Not specifiedCOMPLETEDAcute Effects of Maternal Exercise and the Growth Restricted Pregnancy

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
ASPIRIN42
PRAVASTATIN41

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 20

This page pulls from 20 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogardgenccgwasgwas_studyhgncmedgenmeshmimmondomondochildmondoparentorphanetsctidumls