Plantar fasciitis
diseaseOn this page
Summary
Plantar fasciitis (MONDO:0004833) is a disease and 112 clinical trials. Top therapeutic interventions include cortisone acetate, abobotulinumtoxina, and botulinum toxin type a. A subtype of fasciitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 112
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | plantar fasciitis |
| Mondo ID | MONDO:0004833 |
| MeSH | D036981 |
| DOID | DOID:9600 |
| ICD-11 | 254630809 |
| SNOMED CT | 202882003 |
| UMLS | C0149756 |
| MedGen | 56201 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of fasciitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › fasciitis › plantar fasciitis
Related subtypes (5): nodular fasciitis, proliferative fasciitis, ischemic fasciitis, necrotizing fasciitis, eosinophilic fasciitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Sodium Chloride | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Abobotulinumtoxina, Bupivacaine, Daxibotulinumtoxina, Dexamethasone, Methylprednisolone, Onabotulinumtoxina.
Clinical trials & evidence
Clinical trials
Clinical trials: 112.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 87 |
| PHASE4 | 10 |
| PHASE2 | 6 |
| PHASE2/PHASE3 | 4 |
| PHASE3 | 3 |
| PHASE1 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00189592 | PHASE4 | COMPLETED | Plantar Fasciosis Treatment Using Coblation |
| NCT00222911 | PHASE4 | COMPLETED | Treatment of Plantar Fasciitis With Dorsiflexion Night Splints and Medial Arch Supports |
| NCT00758641 | PHASE4 | COMPLETED | Platelet Rich Plasma to Treat Plantar Fasciitis |
| NCT00888394 | PHASE4 | COMPLETED | Effectiveness of Podiatry on Plantar Pain |
| NCT01326351 | PHASE4 | UNKNOWN | Prolotherapy for the Treatment of Plantar Fasciitis |
| NCT01509274 | PHASE4 | UNKNOWN | Treatment of Plantar Fasciitis With Injection af Platelet-rich Plasma Into the Origin of the Plantar Fascia |
| NCT01588730 | PHASE4 | TERMINATED | Dynamic and Static Splinting as a Treatment for Plantar Faciiopathy |
| NCT01994759 | PHASE4 | COMPLETED | Optimal Treatment of Plantar Fasciitis: Physical Training, Glucocorticoid Injections or a Combination Thereof. |
| NCT02448316 | PHASE4 | COMPLETED | Plantar Fasciitis, Operation or Conservative Treatment |
| NCT02608723 | PHASE4 | COMPLETED | Shock Wave Therapy: Do the External Appearance of the Device Influence Clinical Outcomes? |
| NCT00447876 | PHASE2/PHASE3 | COMPLETED | Study to Assess the Efficacy and Safety of Dysport® in the Treatment of Chronic Plantar Fasciitis |
| NCT00720694 | PHASE3 | COMPLETED | Study of Effectiveness and Safety of Extracorporeal Shock Wave Therapy (ESWT) for Treatment of Painful Heel Syndrome |
| NCT01017406 | PHASE3 | UNKNOWN | Heel Cushion for Plantar Fasciitis |
| NCT01431066 | PHASE3 | COMPLETED | ActiPatch Plantar Fasciitis Clinical Trial |
| NCT01786057 | PHASE2/PHASE3 | UNKNOWN | Effect of Extracorporeal Shock Wave Therapy of Gastrosoleus Trigger Points in Patients With Plantar Fasciitis |
| NCT01957631 | PHASE2/PHASE3 | WITHDRAWN | Comparing Steroid Injections and Platelet Rich Plasma Injections in the Treatment of Plantar Fasciitis |
| NCT05367271 | PHASE2/PHASE3 | COMPLETED | The Efficacy of Botulinum Toxin vs. Corticosteroid for the Treatment of Refractory Plantar Fasciitis |
| NCT07587255 | PHASE2 | NOT_YET_RECRUITING | Efficacy of Extracorporeal Shockwave Therapy on Plantar Fasciitis in Patients With Peripheral Neuropathy |
| NCT02973269 | PHASE2 | TERMINATED | DaxibotulinumtoxinA for Injection for the Management of Plantar Fasciitis |
| NCT03137407 | PHASE2 | COMPLETED | Phase 2 DaxibotulinumtoxinA for Injection for the Management of Plantar Fasciitis |
| NCT03825315 | PHASE2 | COMPLETED | DaxibotulinumtoxinA for Injection for the Treatment of Plantar Fasciitis |
| NCT03978234 | PHASE2 | UNKNOWN | Evaluating the Safety and Effect of abobotulinumtoxinA in the Gastrocnemius Muscle to Improve Equinus and Plantar Fasciitis Pain |
| NCT06169319 | PHASE2 | COMPLETED | A Study to Assess Collagenase Clostridium Histolyticum (CCH) in the Treatment of Plantar Fasciitis (PFA) |
| NCT07395128 | PHASE1 | RECRUITING | Lateral Plantar Artery Embolization For Plantar Fasciitis |
| NCT05868577 | PHASE1 | COMPLETED | Infracalcaneal Peppering Injection Technique for Chronic Plantar Fasciitis |
| NCT02196155 | Not specified | RECRUITING | Botulinum Toxin A Versus Steroids for the Treatment of Chronic Plantar Fasciitis |
| NCT05075005 | Not specified | RECRUITING | The Effects of Terrain Variation on Intrinsic Foot Musculature in Healthy Individuals and Individuals With Plantar Fasciitis |
| NCT05216679 | Not specified | RECRUITING | Novel Stretching Device Versus Night Splints |
| NCT06542211 | Not specified | RECRUITING | Observation on the Efficacy of Improving Ankle Dorsiflexion Limitation in Patients With Plantar Fasciitis |
| NCT06563492 | Not specified | NOT_YET_RECRUITING | The Effect of Insoles in Plantar Fasciitis |
| NCT06589037 | Not specified | NOT_YET_RECRUITING | “Comparison of Shockwave Application on the Sole of the Foot Vs. the Back of the Leg in the Treatment of Plantar Fasciitis: a Clinical Trial.” |
| NCT06674902 | Not specified | NOT_YET_RECRUITING | Electrolysis in Patients With Chronic Plantar Fasciitis |
| NCT06967168 | Not specified | RECRUITING | HeEL Pain Pathways Feasibility Study |
| NCT07006389 | Not specified | ENROLLING_BY_INVITATION | Factors Affecting Response to Extracorporeal Shock Wave Therapy in Plantar Fasciitis: A Cross-sectional Clinical Study |
| NCT07057505 | Not specified | NOT_YET_RECRUITING | Pain and Fascia Thickness After Steroid Injection in Plantar Fasciitis |
| NCT07060352 | Not specified | NOT_YET_RECRUITING | Estimating the Prevalence of GAstrocnemius Muscle REtraction in a Population Suffering From Plantar aPOneurositis and Describing the Effects of Lengthening |
| NCT07070245 | Not specified | ENROLLING_BY_INVITATION | Comparing Instrument Assisted Soft Tissue Mobilization With Positional Release Technique for Plantar Fasciitis Pain and Range of Motion |
| NCT07151066 | Not specified | ENROLLING_BY_INVITATION | Anthropometric Parameters of the Foot and Plantar Fasciitis |
| NCT07179666 | Not specified | NOT_YET_RECRUITING | Comparing Neural Mobilization and Traditional Physiotherapy in Plantar Fasciitis Patients |
| NCT07182201 | Not specified | NOT_YET_RECRUITING | Effect of Foot Core Control Training on Dorsiflexion Function and Gait Biomechanical Characteristics of Patients With Chronic Plantar Fasciitis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CORTISONE ACETATE | 4 | 2 |
| ABOBOTULINUMTOXINA | 4 | 1 |
| BOTULINUM TOXIN TYPE A | 4 | 1 |
| ETHIODIZED OIL | 4 | 1 |
| LIDOCAINE | 4 | 1 |
| SODIUM CHLORIDE | 4 | 1 |
| CORTISONE | 3 | 2 |
| CHEMBL1497313 | 0 | 2 |