Pleural cancer
diseaseOn this page
Also known as cancer of pleuracancer of the pleuramalignant neoplasm of pleuramalignant neoplasm of the pleuramalignant pleura neoplasmmalignant pleural neoplasmmalignant pleural tumormalignant pleural tumourmalignant tumor of pleuramalignant tumor of the pleuramalignant tumour of pleuramalignant tumour of the pleuraneoplasm of pleurapleura cancerpleural tumorpleural tumour
Summary
Pleural cancer (MONDO:0006294) is a cancer and 6 clinical trials. Top therapeutic interventions include bupivacaine and fapi-46 ga-68. A subtype of respiratory system cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 6
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | pleural cancer |
| Mondo ID | MONDO:0006294 |
| EFO | EFO:1000362 |
| DOID | DOID:5158 |
| ICD-10-CM | C38.4 |
| NCIT | C3547 |
| SNOMED CT | 363433009 |
| UMLS | C0153494 |
| MedGen | 56307 |
| Anatomy (UBERON) | UBERON:0000977 |
| Is cancer (heuristic) | yes |
Also known as: cancer of pleura · cancer of the pleura · malignant neoplasm of pleura · malignant neoplasm of the pleura · malignant pleura neoplasm · malignant pleural neoplasm · malignant pleural tumor · malignant pleural tumour · malignant tumor of pleura · malignant tumor of the pleura · malignant tumour of pleura · malignant tumour of the pleura · neoplasm of pleura · pleura cancer · pleural cancer · pleural tumor · pleural tumour
Disease family
This is a subtype of respiratory system cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › respiratory system cancer › pleural cancer
Related subtypes (8): nasal cavity cancer, tracheal cancer, bronchus cancer, larynx cancer, pharynx cancer, lung cancer, SMARCA4-deficient sarcoma of thorax, paranasal sinus cancer
Subtypes (4): malignant pleural solitary fibrous tumor, malignant parietal pleura tumor, malignant visceral pleura tumor, malignant pleural mesothelioma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 6.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 4 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05044468 | PHASE2 | ACTIVE_NOT_RECRUITING | EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement |
| NCT04459273 | PHASE1 | ACTIVE_NOT_RECRUITING | Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers |
| NCT05267496 | Not specified | ACTIVE_NOT_RECRUITING | Oscillating Positive Expiratory Pressure Therapy for Patients With Thoracic Neoplasms Undergoing Chest Surgery |
| NCT00581503 | Not specified | WITHDRAWN | Early Detection and Staging of Endobronchial Lung and Pleural Cancer, Airway Injury, and Prostate Cancer |
| NCT03210298 | Not specified | UNKNOWN | International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) |
| NCT04662645 | Not specified | COMPLETED | Embedded Palliative Care in Managing Symptoms in Participants With Recurrent Stage III-IV Thoracic Malignancies and Their Caregivers |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BUPIVACAINE | 4 | 1 |
| FAPI-46 GA-68 | 2 | 1 |
Related Atlas pages
- Drugs: Bupivacaine