Pleural neoplasm

Summary

Pleural neoplasm (MONDO:0021065) is a cancer (an umbrella term covering 5 Mondo subtypes) and 12 clinical trials. Top therapeutic interventions include diclofenac and ethiodized oil. A subtype of pleural disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 5 Mondo subtypes
• Clinical trials: 12

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	pleural neoplasm
Mondo ID	MONDO:0021065
MeSH	D010997
NCIT	C3332
SNOMED CT	126719004
UMLS	C0032229
MedGen	18523
Anatomy (UBERON)	UBERON:0000977
Is cancer (heuristic)	yes

Also known as: neoplasm of pleura · neoplasm of pleural cavity · neoplasm of the pleura · pleura neoplasm · pleura neoplasm (disease) · pleura tumor · pleura tumour · pleural cavity neoplasm (disease) · pleural cavity tumor · pleural cavity tumour · pleural neoplasm · pleural tumor · pleural tumour · tumor of pleura · tumor of the pleura · tumour of pleura · tumour of the pleura

Disease family

This is a subtype of pleural disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › pleural disorder › pleural neoplasm

Related subtypes (4): pleurisy, pneumothorax, congenital chylothorax, pleural empyema

Subtypes (5): pleural mesothelioma, neurilemmoma of the pleura, pleural cancer, pleural solitary fibrous tumor, benign neoplasm of pleura

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 12.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE4	3
PHASE2	2
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00747916	PHASE4	TERMINATED	Safety, Efficacy, and Side Effects Study of Interventional Cryotherapy in the Pleural Space(ICE PLS)
NCT05077111	PHASE4	UNKNOWN	A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
NCT05121233	PHASE4	UNKNOWN	Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures
NCT05672108	PHASE2	RECRUITING	Phase II Trial of Lung Chemoemobolization
NCT00087698	PHASE2	COMPLETED	Phase II Trial of Neo-Adjuvant Pemetrexed Plus Cisplatin Followed by Surgery and Radiation for Pleural Mesothelioma
NCT06421610	PHASE1	RECRUITING	OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.
NCT03465774	Not specified	RECRUITING	Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions
NCT05267496	Not specified	ACTIVE_NOT_RECRUITING	Oscillating Positive Expiratory Pressure Therapy for Patients With Thoracic Neoplasms Undergoing Chest Surgery
NCT00591981	Not specified	COMPLETED	Thoracic OncoGeriatric Assessment (TOGA) Trials
NCT01776385	Not specified	COMPLETED	The ISET (Isolation by Size of Epithelial Tumor Cells) and the CellSearch Methods in Malignant Pleural Mesothelioma
NCT04731129	Not specified	COMPLETED	Mini Invasive Endomicroscopy of the Pleura for Malignancies Diagnosis
NCT05910112	Not specified	UNKNOWN	Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DICLOFENAC	4	1
ETHIODIZED OIL	4	1