Pneumococcal infection
diseaseOn this page
Also known as infection, pneumococcalinfection, Streptococcus pneumoniaeinfections, pneumococcalinfections, Streptococcus pneumoniaepneumoniae infection, Streptococcuspneumoniae infections, StreptococcusStreptococcus pneumoniae caused disease or disorderStreptococcus pneumoniae disease or disorderStreptococcus pneumoniae infectionStreptococcus pneumoniae infectionsStreptococcus pneumoniae infectious disease
Summary
Pneumococcal infection (MONDO:0005114) is a disease and 176 clinical trials. Top therapeutic interventions include streptococcus pneumoniae polysaccharide conjugated to corynebacterium diphtheriae crm197, colistimethate sodium, and elasomeran. A subtype of streptococcal infection — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 176
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | pneumococcal infection |
| Mondo ID | MONDO:0005114 |
| EFO | EFO:0000772 |
| MeSH | D011008 |
| SNOMED CT | 16814004 |
| UMLS | C0032269 |
| MedGen | 18528 |
| Is cancer (heuristic) | no |
Also known as: infection, pneumococcal · infection, Streptococcus pneumoniae · infections, pneumococcal · infections, Streptococcus pneumoniae · pneumococcal infection · pneumoniae infection, Streptococcus · pneumoniae infections, Streptococcus · Streptococcus pneumoniae caused disease or disorder · Streptococcus pneumoniae disease or disorder · Streptococcus pneumoniae infection · Streptococcus pneumoniae infections · Streptococcus pneumoniae infectious disease
Disease family
This is a subtype of streptococcal infection. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › gram-positive bacterial infections › streptococcal infection › pneumococcal infection
Related subtypes (7): erysipelas, streptococcal meningitis, impetigo, scarlet fever, streptococcal toxic-shock syndrome, streptococcal sore throat, group B streptococcal infection
Subtypes (3): streptococcal pneumonia, pneumococcal meningitis, streptococcus pneumoniae discitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
4 approved, 4 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE CONJUGATED TO CORYNEBACTERIUM DIPHTHERIAE CRM197 | Approved (phase 4) |
| Streptococcus Pneumoniae Polysaccharide Conjugated To Corynebacterium Diphtheriae Toxoid | Approved (phase 4) |
| Streptococcus Pneumoniae Polysaccharide Conjugated To Haemophilus Influenzae Protein D | Approved (phase 4) |
| Streptococcus Pneumoniae Polysaccharide Conjugated To Tetanus Toxoid | Approved (phase 4) |
| Elasomeran | Phase 3 (in late-stage trials) |
| Influenza Virus Vaccine | Phase 3 (in late-stage trials) |
| Penicillin G | Phase 3 (in late-stage trials) |
| Sodium Chloride | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Rituximab.
Clinical trials & evidence
Clinical trials
Clinical trials: 176.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE3 | 54 |
| Not specified | 41 |
| PHASE4 | 27 |
| PHASE1 | 26 |
| PHASE2 | 18 |
| PHASE1/PHASE2 | 7 |
| EARLY_PHASE1 | 2 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04875819 | PHASE4 | RECRUITING | Safety and Immunogenicity Following Meningococcal and Pneumococcal Immunization Among Adult People Living With HIV |
| NCT04945681 | PHASE4 | ACTIVE_NOT_RECRUITING | Evaluating the Effectiveness of a Pneumococcal Immunisation Campaign in a Camp for Internally Displaced People |
| NCT06817421 | PHASE4 | NOT_YET_RECRUITING | Opportunistic Pneumococcal Immunisation Trial in MALnutrition |
| NCT06822907 | PHASE4 | RECRUITING | Immunogenicity and Safety PCV-20 of the Vaccine Administered During an Acute Febrile Illness in Adults |
| NCT00197808 | PHASE4 | COMPLETED | Response of United Kingdom (UK) Infants to a Reduced Primary Schedule With Meningococcal C and Pneumococcal Conjugate Vaccines |
| NCT00276107 | PHASE4 | COMPLETED | Study Evaluating Prevenar Vaccine in Healthy Infants |
| NCT00304382 | PHASE4 | COMPLETED | Humoral Determinants of Immunity to Pneumococcal Infection |
| NCT00368186 | PHASE4 | TERMINATED | Immunogenicity and Safety Study of Pneumococcal 7-Valent Conjugate Vaccine in Sickle Cell Disease Infants. |
| NCT00625677 | PHASE4 | COMPLETED | Study to Evaluate the Immune Response of United Kingdom (UK) Infants Receiving DTaP/Hib/IPV, Meningococcal C Conjugate and Pneumococcal Conjugate Vaccines, Antibody Persistence and Responses to Booster Doses in the Second Year of Life |
| NCT00744263 | PHASE4 | COMPLETED | Study Evaluating the Effiacy of a 13-Valent Pneumococcal Conjugate Vaccine (13vPnC) in Adults |
| NCT01193582 | PHASE4 | COMPLETED | A Study To Assess The Safety And Effectiveness Of Prevenar In Chinese Children Who Have Not Previously Received A Vaccine Against Pneumococcal Bacteria |
| NCT01577771 | PHASE4 | COMPLETED | Immunogenicity and Reactogenicity of PCV13 Among Infants and Children in Burkina Faso |
| NCT02062281 | PHASE4 | COMPLETED | Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults |
| NCT02225327 | PHASE4 | COMPLETED | MF59-adjuvanted Influenza Vaccine and 23-valent Pneumococcal Polysaccharide Vaccine |
| NCT02260882 | PHASE4 | COMPLETED | Revaccination With PNEUMOVAX™ 23 in Older Japanese Adults (V110-902) |
| NCT02582047 | PHASE4 | COMPLETED | Influenza Vaccine and Pneumococcal Vaccine |
| NCT02637583 | PHASE4 | COMPLETED | Sequential Versus Simultaneous Pneumococcal Vaccination in Elderly: Immunological Memory and Antibody Levels |
| NCT02787863 | PHASE4 | COMPLETED | Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology |
| NCT03095326 | PHASE4 | COMPLETED | Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in Indonesia |
| NCT03489018 | PHASE4 | COMPLETED | The Effect of Fractional Doses of Pneumococcal Conjugate Vaccines on Immunogenicity and Carriage in Kenyan Infants |
| NCT03552445 | PHASE4 | COMPLETED | Immunogenicity and Safety of a Tetanus-diphtheria Vaccine and a 13-valent Pneumococcal Conjugate Vaccine |
| NCT03619252 | PHASE4 | COMPLETED | Pneumococcal Vaccination of Multiple Myeloma Patients on Novel Agents |
| NCT04875858 | PHASE4 | UNKNOWN | Immunogenicity After Revaccination With 23-valent Pneumococcal Polysaccharide Vaccine: Healthy Elderly People Versus Diabetic Patients |
| NCT04989465 | PHASE4 | COMPLETED | A Clinical Trial of 23-valent Pneumococcal Polysaccharide Vaccine |
| NCT05477693 | PHASE4 | COMPLETED | Immunogenicity and Safety of 23-valent Pneumococcal Polysaccharide Vaccine |
| NCT05731115 | PHASE4 | COMPLETED | Lot-to-lot Consistency of 23-valent Pneumococcal Polysaccharide Vaccine |
| NCT05767606 | PHASE4 | UNKNOWN | Concomitant Administration of the Novavax Vaccine and a 20-valent Pneumococcal Conjugate Vaccine in Adults Aged ≥60 Years |
| NCT05759520 | PHASE3 | ACTIVE_NOT_RECRUITING | Phase III Clinical Trial of 13-valent Pneumococcal Conjugate Vaccine (Multivalent Conjugate) in Infants |
| NCT06608199 | PHASE3 | RECRUITING | A Phase 3 Study to Evaluate the Immunogenicity and Safety of Minhai’s PCV13-DT/TT Vaccine As Compared to Pfizer’s PCV13 Vaccine |
| NCT06838000 | PHASE3 | ACTIVE_NOT_RECRUITING | Study of the Safety and Immunogenicity of Catch-up Vaccination With a 21-valent Pneumococcal Conjugate Vaccine (PCV21) in Healthy Infants, Toddlers, Children, and Adolescents |
| NCT07017777 | PHASE3 | RECRUITING | A Study to Evaluate the Immunogenicity and Safety of 13-valent Pneumococcal Conjugate Vaccine (PCV13i) in Healthy Infants Aged 2 Months (Minimum 6 Weeks) |
| NCT00127153 | PHASE3 | COMPLETED | A Study of V110 a Pneumococcal Vaccine in Healthy Adults (V110-013) |
| NCT00189020 | PHASE3 | COMPLETED | Effect of Two Versus Three Pneumococcal Conjugate Vaccinations |
| NCT00310349 | PHASE3 | UNKNOWN | PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease |
| NCT00378417 | PHASE3 | COMPLETED | Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes |
| NCT00427895 | PHASE3 | COMPLETED | Study Comparing a 13-valent Pneumococcal Conjugate Vaccine With 23-valent Pneumococcal Polysaccharide Vaccine in Adults |
| NCT00452452 | PHASE3 | COMPLETED | Study Evaluating 13-valent Pneumococcal Conjugate Vaccine Catch-Up Regimens in Older Infants and Children |
| NCT00452790 | PHASE3 | COMPLETED | Study Evaluating 13-valent Pneumococcal Conjugate Vaccine in Healthy Infants in India |
| NCT00492557 | PHASE3 | COMPLETED | Study Evaluating Safety and Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine With Influenza Vaccine in Adults |
| NCT00496093 | PHASE3 | COMPLETED | Safety, Tolerability and Immunogenicity of Pneumovax 23 in Healthy Adults in India (V110-011) |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE CONJUGATED TO CORYNEBACTERIUM DIPHTHERIAE CRM197 | 4 | 8 |
| COLISTIMETHATE SODIUM | 4 | 1 |
| ELASOMERAN | 4 | 1 |
| HEPATITIS B VIRUS HBSAG SURFACE PROTEIN ANTIGEN | 4 | 1 |
| ZINC ION | 3 | 1 |
| CHEMBL1201279 | 0 | 1 |
| CHEMBL4071927 | 0 | 1 |
| CHEMBL4754862 | 0 | 1 |