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Atlas / Disease / Polyp

Polyp

disease
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Summary

Polyp (MONDO:0005079) is a disease (an umbrella term covering 21 Mondo subtypes) with 8 GWAS associations across 8 studies and 70 clinical trials. Top therapeutic interventions include calcium carbonate, folic acid, and propofol. A subtype of cancer or benign tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Umbrella term: 21 Mondo subtypes
  • GWAS associations: 8
  • Clinical trials: 70

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namepolyp
Mondo IDMONDO:0005079
EFOEFO:0000662
MeSHD011127
ICD-10-CMN84
NCITC3340
SNOMED CT441456002
UMLSC0032584
MedGen19397
Is cancer (heuristic)no

Also known as: polyp

Data availability: 8 GWAS associations (8 studies).

Disease family

This is a subtype of cancer or benign tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › polyp

Related subtypes (4): hyperplasia, precancerous condition, neoplastic disease or syndrome, cancer-related condition

Subtypes (21): epulis, polyp of middle ear, uterine polyp, intestinal polyp, hyperplastic polyp, nasal cavity polyp, stomach polyp, neoplastic polyp, polyp of ureter, polyp of large intestine, polyp of vagina, polyp of vulva, polyp of external auditory canal, polyp of sphenoidal sinus, polyp of frontal sinus, polyp of maxillary sinus, polyp of gallbladder, polyp of ethmoidal sinus, polyp of vocal cord, gastrointestinal polyp, fibroepithelial polyp

Genetics & variants

GWAS landscape

8 GWAS associations across 8 studies. Top hits map to 1 distinct genes (as reported by GWAS).

Top associations by p-value

rsIDp-valueGeneRisk alleleOdds ratio
rs1425800299e-32LINC01429 - RNU6-347PG5.49
rs5447842192e-29CASC15G5.87
rs1922162162e-29WARS2P1 - RPA2P2T5.22
rs5501409093e-25CASC15G6.68
rs5645747059e-23CASZ1 - HSPE1P24C5.65
rs1505018382e-13GPRC5B - GPR139C4.21
rs5714851352e-11PTGES - UBE2V1P4G2.17
rs5318416573e-11RNU6-546P - LINC01876A4.8

Top studies (by case count)

StudyLead authorYearCasesControlsTitle
GCST90436361Zhou W20187,408387,338Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
GCST90044177Jiang L20215,167451,181A generalized linear mixed model association tool for biobank-scale data.
GCST90478441Verma A20243,409432,437Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90478440Verma A2024749117,582Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90480332Verma A2024749117,582Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90080111Backman JD2021740387,190Exome sequencing and analysis of 454,787 UK Biobank participants.
GCST90084097Backman JD2021740387,190Exome sequencing and analysis of 454,787 UK Biobank participants.
GCST90478439Verma A202460857,609Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

TierVariants
Tier 1: coding0
Tier 2: splice/UTR0
Tier 3: regulatory1
Tier 4: intronic/intergenic7

MAF distribution

BucketVariants
common (>=0.05)0
low_freq (0.01-0.05)0
rare (<0.01)8
unknown0

Functional consequences

ConsequenceCount
intergenic_variant5
intron_variant2
regulatory_region_variant1

Top variants

rsIDChrPosAllelesMAFConsequenceGenep-valueTier
rs1425800292051872169G>C,T0regulatory_region_variantLINC01429 - RNU6-347P9e-32Tier 3: regulatory
rs544784219622256642G>A0.001intergenic_variantCASC152e-29Tier 4: intronic/intergenic
rs1922162161081061489T>A,C0.001intergenic_variantWARS2P1 - RPA2P22e-29Tier 4: intronic/intergenic
rs550140909621685310G>A,C0.001intron_variantCASC153e-25Tier 4: intronic/intergenic
rs564574705110846424C>T0intergenic_variantCASZ1 - HSPE1P249e-23Tier 4: intronic/intergenic
rs1505018381619987218C>G,T0.001intergenic_variantGPRC5B - GPR1392e-13Tier 4: intronic/intergenic
rs5714851359129774408G>A0.001intron_variantPTGES - UBE2V1P42e-11Tier 4: intronic/intergenic
rs5318416572155348984A>G0intergenic_variantRNU6-546P - LINC018763e-11Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated or in trials for this disease

No drug has an approved disease-direct ChEMBL indication for this disease.

6 drugs in clinical trials for this disease (phase 2–3, investigational): efficacy not established — a trial record, not an indication.

DrugHighest phase
PropofolPhase 3
Soybean OilPhase 3
Fluticasone PropionatePhase 2
HypromellosePhase 2
MethylprednisolonePhase 2
Sodium ChloridePhase 2

Clinical trials & evidence

Clinical trials

Clinical trials: 70.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified58
PHASE46
PHASE2/PHASE32
PHASE12
PHASE31
PHASE21

Top trials by phase / activity

NCTPhaseStatusTitle
NCT00114842PHASE4COMPLETEDMagnetic Resonance (MR) Colonography With Fecal Tagging
NCT00332943PHASE4COMPLETEDMR Colonography With Fecal Tagging. Barium vs. BariumFerumoxsil
NCT01124266PHASE4COMPLETEDEndoscopy Nurse Participation in Adenoma Detection Rate During Colonoscopy
NCT01461564PHASE4COMPLETEDCarbon Dioxide During Screening Unsedated Colonoscopy
NCT01807169PHASE4COMPLETEDRecto Colonic Endoscopic Mucosal Resection and Polypectomy Under Clopidogrel
NCT02937506PHASE4COMPLETEDPatient Satisfaction With Propofol for Out Patient Colonoscopy
NCT00153816PHASE2/PHASE3COMPLETEDVitamin D/Calcium Polyp Prevention Study
NCT00272324PHASE2/PHASE3COMPLETEDAspirin/Folate Prevention of Large Bowel Polyps
NCT00339625PHASE3COMPLETEDPolyp Prevention Trial
NCT05865496PHASE2UNKNOWNA Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps
NCT01451008PHASE1COMPLETEDCompression Anastomosis Using the Compression Anastomotic Ring-locking Procedure (CARP)
NCT01560377PHASE1COMPLETEDPerfusion Assessment in Laparoscopic Left Anterior Resection
NCT03708952Not specifiedACTIVE_NOT_RECRUITINGLifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases
NCT05064124Not specifiedRECRUITINGEarly DiAgnosis Real-Time Healthcare System for CANcer Trial
NCT05551052Not specifiedACTIVE_NOT_RECRUITINGCRC Detection Reliable Assessment With Blood
NCT06481007Not specifiedNOT_YET_RECRUITINGALgerian Cholecystectomy Outcomes and Determinants Study (AL-CODS)
NCT07035691Not specifiedRECRUITINGNew bioMarkers tO straTIfy cOlorectal caNcer Referrals
NCT00124163Not specifiedUNKNOWNEvaluation of Stool Tagging for Improved Patient Compliance
NCT00145015Not specifiedCOMPLETEDFishGastro Study: Fish Consumption and Gastro-Intestinal Health
NCT00234650Not specifiedCOMPLETEDAdenoma Detection Rate With Position Change at Colonoscopy
NCT00237276Not specifiedUNKNOWNExperience and Enhancement: Improving Colonoscopic Polyp Detection
NCT00245492Not specifiedCOMPLETEDChromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening.
NCT00323999Not specifiedUNKNOWNHysteroscopic Monopolar and Bipolar Resection
NCT00553436Not specifiedCOMPLETEDEvaluation of an Endoscopic Suturing System for Tissue Apposition in Colonic Polypectomy
NCT00577083Not specifiedCOMPLETEDCap-fitted Colonoscopy: a Randomized, Tandem Colonoscopy Study of Adenoma Miss Rates
NCT00792649Not specifiedUNKNOWNComparison Between HD+ Endoscopy and Standard Videoendoscopy in Screening Colonoscopy
NCT00979342Not specifiedCOMPLETEDComparative Sedation Study of the MyoSure Hysteroscopic Tissue Removal System
NCT01152112Not specifiedCOMPLETEDHOME Study: Hysteroscopic Office Myomectomy Evaluation
NCT01369758Not specifiedCOMPLETEDMyoSure Hysteroscopic Tissue Removal System Registry Study
NCT01430208Not specifiedCOMPLETEDA New Alternative to Traditional Hysteroscopy
NCT01481337Not specifiedCOMPLETEDEndoscopic Mucosal Colonic Resection and Polypectomy Under Aspirin
NCT01552200Not specifiedCOMPLETEDPerformance Evaluation of the NaviAid™ G-Eye System
NCT01688557Not specifiedCOMPLETEDTrial on Innovative Technologies in Colonoscopy
NCT01735266Not specifiedCOMPLETEDLeft-colon WEC May Reduce Insertion Time Compared With Whole-colon WEC.
NCT01749722Not specifiedCOMPLETEDSafety and Efficacy of the NaviAid™ G-Eye System During Colonoscopy
NCT01820182Not specifiedCOMPLETEDProspective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule
NCT01917513Not specifiedCOMPLETEDProspective Trial to Compare the Clinical Efficiency of G-EYE™ HD Colonoscopy With Standard HD Colonoscopy
NCT02034929Not specifiedCOMPLETEDEndoCuff-assisted Versus Standard Colonoscopy for Adenoma Detection
NCT02133027Not specifiedUNKNOWNRole of the Right Portal Pedicle and Rouviere’s Sulcus as an Anatomic Landmark in Laparoscopic Cholecystectomy
NCT02292563Not specifiedCOMPLETEDThe Impact of Experienced Endoscopy Nurse Participation on Polyp and Adenoma Detection During Colonoscopy

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
CALCIUM CARBONATE41
FOLIC ACID41
PROPOFOL41

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 21

This page pulls from 21 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardbsnpefogenccgwasgwas_studyhgncicd10cmmedgenmeshmimmondomondochildmondoparentncitorphanetsctidumls