Polyposis

Summary

Polyposis (MONDO:0000147) is a disease and 6 clinical trials. Top therapeutic interventions include budesonide. A subtype of neoplastic polyp — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 6

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	polyposis
Mondo ID	MONDO:0000147
NCIT	C4089
UMLS	C0334108
MedGen	137722
Is cancer (heuristic)	no

Also known as: multiple polyps · polyposis

Disease family

This is a subtype of neoplastic polyp. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › polyp › neoplastic polyp › polyposis

Subtypes (4): polyposis, intestinal, scattered and discrete, gastric adenocarcinoma and proximal polyposis of the stomach, POLE-related polyposis and colorectal cancer syndrome, POLD1-related polyposis and colorectal cancer syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 6.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3
PHASE3	1
PHASE1/PHASE2	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01197612	PHASE3	COMPLETED	Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis
NCT01946711	PHASE1/PHASE2	COMPLETED	Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi
NCT04094675	PHASE2	COMPLETED	Sirolimus for Cowden Syndrome With Colon Polyposis
NCT04013152	Not specified	ACTIVE_NOT_RECRUITING	Clinical Database of Colorectal Robotic Surgery
NCT06455384	Not specified	RECRUITING	The Genetics Navigator: Evaluating a Digital Platform for Genomics Health Services
NCT02592603	Not specified	COMPLETED	Endocuff for Surveillance of Serrated Polyposis Syndrome

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BUDESONIDE	4	2