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Atlas / Disease / Post-thrombotic syndrome

Post-thrombotic syndrome

disease
On this page

Also known as postphlebitic syndrome

Summary

Post-thrombotic syndrome (MONDO:0005928) is a disease and 41 clinical trials. Top therapeutic interventions include alteplase, rivaroxaban, and sulodexide. A subtype of venous insufficiency — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 41

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namepost-thrombotic syndrome
Mondo IDMONDO:0005928
EFOEFO:0007452
MeSHD011186
DOIDDOID:2364
ICD-10-CMI87.0
SNOMED CT20427003
UMLSC0032807
MedGen46043
Is cancer (heuristic)no

Also known as: postphlebitic syndrome

Disease family

This is a subtype of venous insufficiency. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › vein disorder › venous insufficiency › post-thrombotic syndrome

Related subtypes (1): chronic venous insufficiency

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 41.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified27
PHASE37
PHASE45
PHASE21
PHASE1/PHASE21

Top trials by phase / activity

NCTPhaseStatusTitle
NCT01432795PHASE4COMPLETEDPracticability of Gliding Aids for Medical Compression Stockings
NCT02159521PHASE4COMPLETEDTreatment of Chronic Deep Vein Thrombosis (DVT) and Post-Thrombotic Syndrome (PTS) With the EkoSonic® Endovascular System
NCT02512601PHASE4TERMINATEDProspective Evaluation of the QoL of Patients With PTS Who Receive Compression Therapy and Sulodexide
NCT04411316PHASE4WITHDRAWNCatheter-directed Thrombolysis Compared to Anticoagulation Alone for Acute Primary Iliofemoral Deep Venous Thrombosis
NCT04794569PHASE4TERMINATEDTinzaparin Lead-In to Prevent the Post-Thrombotic Syndrome
NCT04319627PHASE3RECRUITINGStatins for Venous Event Reduction in Patients With Venous Thromboembolism
NCT06925698PHASE3NOT_YET_RECRUITINGImmunosuppressive Therapy Alone Versus Plus Oral Anticoagulation in the Treatment of VT Associated With Behcet’s Disease
NCT07432529PHASE3NOT_YET_RECRUITINGDesign and Rationale of the COLT Study
NCT00182208PHASE3COMPLETEDEvaluation of a Venous-Return Assist Device (Venowave) to Treat Post-Thrombotic Syndrome: A Randomized Controlled Trial
NCT00790335PHASE3COMPLETEDAcute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
NCT02767232PHASE3WITHDRAWNPediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial
NCT03833024PHASE3UNKNOWNThe MUFFIN-PTS Trial
NCT01637428PHASE2UNKNOWNThe Use of Intermittent Pneumatic Compression Device for Symptomatic Relief in Patients With Post Thrombotic Syndrome
NCT04833764PHASE1/PHASE2UNKNOWNMechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis
NCT03250247Not specifiedACTIVE_NOT_RECRUITINGChronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)
NCT05701917Not specifiedRECRUITINGDEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis
NCT07473284Not specifiedNOT_YET_RECRUITINGIncidence and Characteristic of CRT Persistent After Catheter Extraction in ICU Patients
NCT00633971Not specifiedCOMPLETEDTreatment Trial for Post-Thrombotic Syndrome
NCT00858130Not specifiedCOMPLETEDPilot Study for VeinoPlus to Improve Symptoms of Postthrombotic Syndrome (PTS)
NCT01578122Not specifiedCOMPLETEDElastic Compression Stockings for Prevention of Post-thrombotic Syndrome
NCT01615692Not specifiedWITHDRAWNThe 36-month Extension to Follow up Sub Study
NCT01846780Not specifiedCOMPLETEDTreadmill Pilot Study (Invasive Pressure Measurements in PTS)
NCT02113475Not specifiedUNKNOWNVenous Thrombectomy/Thrombolysis Outcome Registry
NCT02268630Not specifiedUNKNOWNLong Term Outcomes of Venous Thromboembolism
NCT02433054Not specifiedCOMPLETEDBern Venous Stent Registry
NCT02942394Not specifiedCOMPLETEDTreatment of the Postthrombotic Syndrome With the Oblique Stent - TOPOS Study
NCT03039517Not specifiedWITHDRAWNPost Thrombotic Syndrome Prevention Study
NCT03054727Not specifiedCOMPLETEDLong Term Assessment of Post Thrombotic Syndrome : OPTIMEV Study ( SPOT )
NCT03075761Not specifiedCOMPLETEDPhysical Activity in Children at Risk of Post-thrombotic Sequelae (PACT)
NCT03195777Not specifiedCOMPLETEDNovel PET/CT and Treatment Strategies to Reduce PTS Following DVT
NCT03368313Not specifiedUNKNOWNNon-elastic Compression Garment Therapy Versus Control for Deep Vein Thrombosis
NCT03757481Not specifiedCOMPLETEDLong-term Outcome After Heparin and Edoxaban Versus Heparin Plus Vit K Antagonists for Acute DVT and PE
NCT04007653Not specifiedUNKNOWNLong-term Outcome After Edoxaban Versus Vitamin K Antagonists for Acute VTE
NCT04103112Not specifiedTERMINATEDCompression Hosiery to Avoid Post-Thrombotic Syndrome
NCT04250025Not specifiedUNKNOWNAngioplasty-stenting vs Optimal Medical Treatment on Post-thrombotic Syndrome Reduction
NCT04825548Not specifiedCOMPLETEDPost-thrombotic Syndrome After Deep Venous Thrombosis (DVT) in Patients Treated According to the NOPHO ALL2008 Protocol
NCT05296499Not specifiedUNKNOWNEXERT: Exercise Physiology After Thrombosis
NCT05622500Not specifiedTERMINATEDBest Endovenous Treatment, Including STenting, Versus Non-endovenous Treatment in Chronic Proximal Deep Venous Disease
NCT05744843Not specifiedUNKNOWNStructured Exercise Versus Endovascular Reconstruction in Post Thrombotic Syndrome
NCT05794932Not specifiedCOMPLETEDExercise Tolerance After Venous Recanalization for Post-thrombotic Syndrome

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
ALTEPLASE41
RIVAROXABAN41
SULODEXIDE31
TINZAPARIN31

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 20

This page pulls from 20 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogenccgwasgwas_studyhgncicd10cmmedgenmeshmimmondomondochildmondoparentorphanetsctidumls