Post-traumatic epilepsy
diseaseOn this page
Also known as concussive convulsionconcussive convulsionsconvulsion, concussiveconvulsions, concussivedisorder, post-traumatic seizuredisorders, post-traumatic seizureearly post traumatic seizuresearly post-traumatic seizureearly post-traumatic seizuresEpilepsies, post-traumaticEpilepsies, traumaticepilepsy, post traumaticepilepsy, traumaticimpact seizureimpact seizureslate post traumatic seizureslate post-traumatic seizurelate post-traumatic seizurespost traumatic seizure disorderpost-traumatic Epilepsies
Summary
Post-traumatic epilepsy (MONDO:0043264) is a disease and 10 clinical trials. Top therapeutic interventions include levetiracetam, phenytoin, and biperiden. A subtype of epilepsy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 10
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | post-traumatic epilepsy |
| Mondo ID | MONDO:0043264 |
| MeSH | D004834 |
| SNOMED CT | 75023009 |
| UMLS | C0014557 |
| MedGen | 4991 |
| Is cancer (heuristic) | no |
Also known as: concussive convulsion · concussive convulsions · convulsion, concussive · convulsions, concussive · disorder, post-traumatic seizure · disorders, post-traumatic seizure · early post traumatic seizures · early post-traumatic seizure · early post-traumatic seizures · Epilepsies, post-traumatic · Epilepsies, traumatic · epilepsy, post traumatic · epilepsy, traumatic · impact seizure · impact seizures · late post traumatic seizures · late post-traumatic seizure · late post-traumatic seizures · post traumatic seizure disorder · post-traumatic Epilepsies (+16 more)
Disease family
This is a subtype of epilepsy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › brain disorder › epilepsy › post-traumatic epilepsy
Related subtypes (12): extratemporal epilepsy, focal epilepsy, epilepsy syndrome, monogenic epilepsy, reflex epilepsy, immune epilepsy, metabolic epilepsy, structural epilepsy, infantile-onset epilepsy, generalized epilepsy, epilepsy, unknown whether focal or generalized, developmental and epileptic encephalopathy
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 10.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 4 |
| PHASE3 | 3 |
| PHASE2 | 2 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04945213 | PHASE3 | RECRUITING | Biperiden Trial for Epilepsy Prevention |
| NCT00004817 | PHASE3 | COMPLETED | Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures |
| NCT00566046 | PHASE3 | TERMINATED | Prevention of Post-traumatic Seizures With Levetiracetam |
| NCT01463033 | PHASE2 | COMPLETED | Levetiracetam to Prevent Post-Traumatic Epilepsy |
| NCT06523725 | PHASE2 | WITHDRAWN | Trial Investigating the Safety and Efficacy of BRC-003 in Refractory Post-Traumatic Epilepsy |
| NCT03999164 | PHASE1 | ACTIVE_NOT_RECRUITING | Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy |
| NCT05235061 | Not specified | ACTIVE_NOT_RECRUITING | HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) -Post-Traumatic Epilepsy (PTE) |
| NCT05353452 | Not specified | RECRUITING | Collaborative Care in Posttraumatic Epilepsy |
| NCT05823766 | Not specified | ACTIVE_NOT_RECRUITING | Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI) |
| NCT03441867 | Not specified | UNKNOWN | Neuroimaging Biomarker for Seizures |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LEVETIRACETAM | 4 | 2 |
| PHENYTOIN | 4 | 2 |
| BIPERIDEN | 4 | 1 |
| VALPROATE SODIUM | 4 | 1 |
| ETIRACETAM | 2 | 1 |
| CHEMBL1617470 | 0 | 1 |
| LEVITIRACETAM | 0 | 1 |
Related Atlas pages
- Drugs: Levetiracetam, Phenytoin, Biperiden, Valproate