Postorgasmic illness syndrome

Summary

Postorgasmic illness syndrome (MONDO:0017213) is a disease. A subtype of urinary system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 18

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		45	Worldwide	Validated
Point prevalence	<1 / 1 000 000		Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

18 HPO clinical features (Orphanet curated; top 18 by frequency):

HPO ID	Term	Frequency
HP:0011446	Abnormality of higher mental function	Very frequent (80-99%)
HP:0012378	Fatigue	Very frequent (80-99%)
HP:0000366	Abnormality of the nose	Frequent (30-79%)
HP:0000737	Irritability	Frequent (30-79%)
HP:0000822	Hypertension	Frequent (30-79%)
HP:0000975	Hyperhidrosis	Frequent (30-79%)
HP:0001945	Fever	Frequent (30-79%)
HP:0002315	Headache	Frequent (30-79%)
HP:0000217	Xerostomia	Occasional (5-29%)
HP:0000613	Photophobia	Occasional (5-29%)
HP:0000622	Blurred vision	Occasional (5-29%)
HP:0000716	Depression	Occasional (5-29%)
HP:0000750	Delayed speech and language development	Occasional (5-29%)
HP:0001260	Dysarthria	Occasional (5-29%)
HP:0001324	Muscle weakness	Occasional (5-29%)
HP:0001609	Hoarse voice	Occasional (5-29%)
HP:0001962	Palpitations	Occasional (5-29%)
HP:0003552	Muscle stiffness	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	postorgasmic illness syndrome
Mondo ID	MONDO:0017213
Orphanet	279947
ICD-11	1094271130
UMLS	C4749582
MedGen	1663577
GARD	0010809
Is cancer (heuristic)	no

Also known as: POIS · post orgasmic sick syndrome

Disease family

This is a subtype of urinary system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › urinary system disorder › postorgasmic illness syndrome

Related subtypes (19): bacteriuria, ureteral disorder, pyuria, urinary tract obstruction, urethral disorder, kidney disorder, urinary bladder disorder, hyperglycinuria, hypercalciuria, absorptive, 2, hypercalciuria, absorptive, 1, megacystis-megaureter syndrome, congenital urachal anomaly, urinary system neoplasm, urothelial hyperplasia, urolithiasis, urinary tract infection, meningitis-retention syndrome, paraneoplastic renal syndrome, idiopathic hypercalciuria

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.