Posttransplant acute limbic encephalitis
diseaseOn this page
Also known as PALE
Summary
Posttransplant acute limbic encephalitis (MONDO:0015595) is a disease. A subtype of limbic encephalitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide)
- Phenotypes (HPO): 23
Clinical features
Signs & symptoms
Clinical features (HPO)
23 HPO clinical features (Orphanet curated; top 23 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0001250 | Seizure | Frequent (30-79%) |
| HP:0002354 | Memory impairment | Frequent (30-79%) |
| HP:0002902 | Hyponatremia | Frequent (30-79%) |
| HP:0002922 | Increased CSF protein concentration | Frequent (30-79%) |
| HP:0011185 | EEG with focal epileptiform discharges | Frequent (30-79%) |
| HP:0012756 | CSF polymorphonuclear pleocytosis | Frequent (30-79%) |
| HP:0020071 | Viremia | Frequent (30-79%) |
| HP:0031885 | Hyperglycorrhachia | Frequent (30-79%) |
| HP:0100806 | Sepsis | Frequent (30-79%) |
| HP:0200149 | CSF lymphocytic pleiocytosis | Frequent (30-79%) |
| HP:0000708 | Atypical behavior | Occasional (5-29%) |
| HP:0000709 | Psychosis | Occasional (5-29%) |
| HP:0000716 | Depression | Occasional (5-29%) |
| HP:0000739 | Anxiety | Occasional (5-29%) |
| HP:0001251 | Ataxia | Occasional (5-29%) |
| HP:0001289 | Confusion | Occasional (5-29%) |
| HP:0001332 | Dystonia | Occasional (5-29%) |
| HP:0001336 | Myoclonus | Occasional (5-29%) |
| HP:0011203 | EEG with abnormally slow frequencies | Occasional (5-29%) |
| HP:0012332 | Abnormal autonomic nervous system physiology | Occasional (5-29%) |
| HP:0025100 | Abnormal hippocampus morphology | Occasional (5-29%) |
| HP:0100022 | Abnormality of movement | Occasional (5-29%) |
| HP:0100543 | Cognitive impairment | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | posttransplant acute limbic encephalitis |
| Mondo ID | MONDO:0015595 |
| Orphanet | 163921 |
| UMLS | C4750744 |
| MedGen | 1657779 |
| GARD | 0020051 |
| Is cancer (heuristic) | no |
Also known as: PALE · pale
Disease family
This is a subtype of limbic encephalitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › encephalomyelitis › encephalitis › limbic encephalitis › posttransplant acute limbic encephalitis
Related subtypes (5): paraneoplastic limbic encephalitis, non-herpetic acute limbic encephalitis, limbic encephalitis with caspr2 antibodies, limbic encephalitis with DPP6 antibodies, autoimmune limbic encephalitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.