Preaxial polydactyly of toes

Summary

Preaxial polydactyly of toes (MONDO:0017457) is a disease. A subtype of non-syndromic polydactyly — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	Preaxial polydactyly of toes
Mondo ID	MONDO:0017457
Orphanet	295006
ICD-11	1685587490
SNOMED CT	205132000
UMLS	C0432036
MedGen	609309
GARD	0012771
Is cancer (heuristic)	no

Also known as: bifid great toes · bifid halluces · bifid hallux · preaxial polydactyly of foot

Disease family

An umbrella term covering 2 Mondo subtypes.

Classification path: disease › human disease › disease by etiologic mechanism › disease of genetic or genomic mechanism › hereditary disease › polydactyly › non-syndromic polydactyly › Preaxial polydactyly of toes

Related subtypes (9): polysyndactyly 4, synpolydactyly type 1, synpolydactyly type 2, preaxial polydactyly of fingers, postaxial polydactyly of fingers, central polydactyly of fingers, megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome, postaxial polydactyly, mirror-image polydactyly

Subtypes (2): Preaxial polydactyly of toes, unilateral, Preaxial polydactyly of toes, bilateral

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.