Pregnancy disorder with abortive outcome
diseaseOn this page
Also known as intrauterine fetal deathintrauterine fetal demiseIUFDpregnancy with abortive outcomestillbirth
Summary
Pregnancy disorder with abortive outcome (MONDO:0041526) is a disease and 73 clinical trials. Top therapeutic interventions include epoetin beta, folic acid, and mifepristone. A subtype of pregnancy disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 73
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | pregnancy disorder with abortive outcome |
| Mondo ID | MONDO:0041526 |
| ICD-10-CM | O00-O08 |
| SNOMED CT | 363681007 |
| UMLS | C0156543 |
| MedGen | 102352 |
| Is cancer (heuristic) | no |
Also known as: intrauterine fetal death · intrauterine fetal demise · IUFD · pregnancy with abortive outcome · stillbirth
Disease family
This is a subtype of pregnancy disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › obstetric disorder › pregnancy disorder › pregnancy disorder with abortive outcome
Related subtypes (28): funisitis, chorea gravidarum, luteoma of pregnancy, polyhydramnios, impetigo herpetiformis, gestational diabetes, placenta disorder, pemphigoid gestationis, dystocia, hyperemesis gravidarum, pruritic urticarial papules and plaques of pregnancy, familial gestational hyperthyroidism, pseudohyperaldosteronism type 2, aromatase deficiency, acute fatty liver of pregnancy, malignancy diagnosed during pregnancy, postpartum psychosis, peripartum cardiomyopathy, gestational trophoblastic neoplasm, hypertension, pregnancy-induced, chronic intervillositis of unknown etiology, postpartum amenorrhea-galactorrhea syndrome, pregnancy associated osteoporosis, twin anemia-polycythemia sequence, twin-reversed arterial perfusion sequence, selective intrauterine growth restriction, amniotic fluid embolism, vasa previa
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 73.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 65 |
| PHASE3 | 4 |
| PHASE4 | 3 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05757167 | PHASE4 | ACTIVE_NOT_RECRUITING | Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics |
| NCT00270530 | PHASE4 | COMPLETED | Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia |
| NCT02620904 | PHASE4 | TERMINATED | Mifepristone Induction for Fetal Demise |
| NCT06723392 | PHASE3 | RECRUITING | Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries |
| NCT07537894 | PHASE2/PHASE3 | NOT_YET_RECRUITING | Perioperative Dexmedetomidine to Reduce Post-procedure Grief Following Second-trimester Dilation and Evacuation |
| NCT00133744 | PHASE3 | COMPLETED | Impact of Prenatal Vitamin/Mineral Supplements on Perinatal Mortality |
| NCT00671060 | PHASE3 | COMPLETED | Misoprostol for Treatment of Fetal Death at 14-28 Weeks of Pregnancy |
| NCT02336243 | PHASE3 | UNKNOWN | A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders |
| NCT02738892 | Not specified | ACTIVE_NOT_RECRUITING | Zambian Preterm Birth Prevention Study |
| NCT03662178 | Not specified | RECRUITING | Investigating the Structured Use of Ultrasound Scanning for Fetal Growth |
| NCT03775954 | Not specified | RECRUITING | Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise |
| NCT04393259 | Not specified | RECRUITING | The Tommy’s National Rainbow Clinic Study |
| NCT04905537 | Not specified | RECRUITING | Study on Early Genetic Screening and Precise Strategy of Neonatal Critical Illness |
| NCT06125860 | Not specified | ACTIVE_NOT_RECRUITING | BEP Targeting Strategies in Ethiopia |
| NCT06273007 | Not specified | RECRUITING | Improving Intrapartum Care for Saving Life at Birth in Ethiopia Through PartoMa Approach |
| NCT06825481 | Not specified | NOT_YET_RECRUITING | Uterine Doppler As StillbirthPredictor |
| NCT06918236 | Not specified | RECRUITING | Association of Assisted Reproductive Technologies Parameters With the Perinatal Outcome |
| NCT07011940 | Not specified | NOT_YET_RECRUITING | Walk With Me (WWM) for Perinatal Grief |
| NCT07015203 | Not specified | RECRUITING | The Combined First Trimester Screening |
| NCT07144839 | Not specified | RECRUITING | Placental Risk Assessment to CusTomize Individualized Pregnancy Care and Evaluation |
| NCT07494760 | Not specified | NOT_YET_RECRUITING | A Feasibility Randomised Control Trial to Evaluate Early Perinatal Bereavement Counselling for Parents Who Have Experienced a Perinatal Death |
| NCT00573118 | Not specified | UNKNOWN | Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity |
| NCT00856076 | Not specified | UNKNOWN | Venous Thromboembolism in Pregnancy Study |
| NCT00878098 | Not specified | COMPLETED | Study of DDT and Loss of Clinically-Recognized Pregnancies in South Africa |
| NCT01229189 | Not specified | COMPLETED | Evaluation of the Effectiveness of Vitamin D Supplementation to Pregnant Women and Their Infants in Pakistan. |
| NCT01417962 | Not specified | COMPLETED | Magnetic Resonance Imaging Autopsy Study |
| NCT01664546 | Not specified | UNKNOWN | Study of the Best Blastocyst Post Transfer by aCGH |
| NCT01777022 | Not specified | COMPLETED | Promoting Awareness Fetal Movements to Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial. |
| NCT01867749 | Not specified | COMPLETED | Group Interpersonal Psychotherapy for Treatment of Major Depressive Disorder Following Perinatal Loss |
| NCT01888380 | Not specified | COMPLETED | The Paediatric Virtual Autopsy Trial |
| NCT01916928 | Not specified | COMPLETED | The Use of Cell Free Fetal DNA in the Maternal Blood in the Evaluation of Intrauterine Fetal Demise and Miscarriage |
| NCT01990625 | Not specified | COMPLETED | A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings |
| NCT01995968 | Not specified | UNKNOWN | Antenatal Detection of Fetal Growth Restriction and Stillbirths Rate. |
| NCT02025530 | Not specified | COMPLETED | The Midlands and North of England Stillbirth Study |
| NCT02039583 | Not specified | COMPLETED | Impact of Smoke-free Legislation on Early-life Mortality and Low Birth Weight in England |
| NCT02148952 | Not specified | COMPLETED | BetterBirth: A Trial of the WHO Safe Childbirth Checklist Program |
| NCT02185625 | Not specified | COMPLETED | Reduction of Adverse Pregnancy Outcomes With a Smartphone Application in Ghana |
| NCT02189265 | Not specified | COMPLETED | Assessing the Impact of Smoke-free Legislation on Perinatal Health in the Netherlands |
| NCT02218931 | Not specified | COMPLETED | ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes |
| NCT02273037 | Not specified | COMPLETED | Intermittent Auscultation Using Handheld Doppler: a Randomized Controlled Trial Comparing Perinatal Outcomes in Uganda |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| EPOETIN BETA | 4 | 1 |
| FOLIC ACID | 4 | 1 |
| MIFEPRISTONE | 4 | 1 |
Related Atlas pages
- Drugs: Epoetin Beta, Folic Acid, Mifepristone