Primary brain neoplasm
diseaseOn this page
Also known as primary brain tumorprimary brain tumour
Summary
Primary brain neoplasm (MONDO:0021632) is a cancer and 49 clinical trials. Top therapeutic interventions include ferumoxytol, aminolevulinic acid, and entrectinib. A subtype of brain neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 49
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | primary brain neoplasm |
| Mondo ID | MONDO:0021632 |
| NCIT | C170814, C4952 |
| UMLS | C0750974 |
| MedGen | 152924 |
| Is cancer (heuristic) | yes |
Also known as: primary brain neoplasm · primary brain tumor · primary brain tumour
Disease family
This is a subtype of brain neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › brain disorder › brain neoplasm › primary brain neoplasm
Related subtypes (16): brain cancer, cerebellopontine angle tumor, olfactory nerve neoplasm, cerebellar neoplasm, childhood brain meningioma, olfactory groove meningioma, dysembryoplastic neuroepithelial tumor, hypothalamic neoplasm, optic pathway glioma, choroid plexus neoplasm, brainstem neoplasm, pineal body neoplasm, neoplasm of cerebral hemisphere, benign neoplasm of brain, optic tract meningioma, infratentorial neoplasm
Subtypes (1): brain astrocytoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 49.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 30 |
| PHASE2 | 7 |
| PHASE1 | 5 |
| EARLY_PHASE1 | 3 |
| PHASE4 | 2 |
| PHASE3 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00571155 | PHASE4 | COMPLETED | Trial of Levetiracetam in Patients With Primary Brain Tumors and Symptomatic Seizures Who Undergo Surgery |
| NCT02034708 | PHASE4 | COMPLETED | Efficacy Evaluation of Dotarem®-Enhanced MRI Compared to Gadovist®/Gadavist®-Enhanced MRI in the Diagnosis of Brain Tumors |
| NCT00241670 | PHASE3 | COMPLETED | Fluorescence-guided Resection of Malignant Gliomas With 5-Aminolevulinic Acid |
| NCT00430911 | PHASE3 | COMPLETED | Radiotherapy for Malignant Astrocytomas in the Elderly |
| NCT02568267 | PHASE2 | ACTIVE_NOT_RECRUITING | Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) |
| NCT00659126 | PHASE2 | TERMINATED | Ferumoxytol- and Gadolinium-Labeled MRI in Measuring Tumors Before or After Treatment in Patients With Primary or Metastatic Brain Tumors |
| NCT01242566 | PHASE2 | COMPLETED | Temozolomide in Elderly Patients With KPS < 70 |
| NCT01472731 | PHASE2 | COMPLETED | Safety and Imaging Study of GC1008 in Glioma |
| NCT02038218 | PHASE2 | COMPLETED | Study of 4-Demethyl-4-cholesteryloxycarbonylpenclome (DM-CHOC-PEN) in Patients With Brain Tumors |
| NCT02898012 | PHASE2 | COMPLETED | Temozolomide Plus Bevacizumab in Supratentorial Glioblastoma in 70 Years and Older Patients With an Impaired Functional Status |
| NCT06439420 | PHASE2 | COMPLETED | CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial |
| NCT03830151 | PHASE1 | RECRUITING | Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors |
| NCT05106296 | PHASE1 | RECRUITING | Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer |
| NCT06104488 | PHASE1 | RECRUITING | A Study of Avutometinib for People With Solid Tumor Cancers |
| NCT00639262 | PHASE1 | COMPLETED | Combination of Sorafenib and Radiation for Brain Metastases and Primary Brain Tumors |
| NCT01528046 | PHASE1 | COMPLETED | Metformin in Children With Relapsed or Refractory Solid Tumors |
| NCT05634707 | EARLY_PHASE1 | ACTIVE_NOT_RECRUITING | Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT) |
| NCT02338037 | EARLY_PHASE1 | COMPLETED | Neuropharmacokinetics of Eribulin Mesylate in Treating Patients With Primary or Metastatic Brain Tumors |
| NCT02452216 | EARLY_PHASE1 | COMPLETED | Using Ferumoxytol-Enhanced MRI to Measure Inflammation in Patients With Brain Tumors or Other Conditions of the CNS |
| NCT01535430 | Not specified | RECRUITING | Assessment of Eloquent Function in Brain Tumor Patients |
| NCT03684109 | Not specified | RECRUITING | Non-invasive Glioma Characterization Through Molecular Imaging |
| NCT04066465 | Not specified | RECRUITING | Neurocognitive Function After Proton Therapy in Children and Adolescents |
| NCT04306432 | Not specified | RECRUITING | Cognitive Function After Radiation Therapy for Primary Brain Tumours |
| NCT04988009 | Not specified | RECRUITING | Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology |
| NCT05539677 | Not specified | RECRUITING | Biobank and Register of Patients With Agresive Tumors for Translational and Analytical Research |
| NCT05576103 | Not specified | RECRUITING | Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients |
| NCT06799481 | Not specified | RECRUITING | Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors |
| NCT06831461 | Not specified | RECRUITING | Proton Versus Photon Radiotherapy in Adults With Primary Brain Tumors |
| NCT06930846 | Not specified | RECRUITING | HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer) |
| NCT07278440 | Not specified | NOT_YET_RECRUITING | An Exercise Intervention for Improving Mental and Physical Health in Patients With Primary Brain Tumors and Their Caregivers, ET-NEURO Trial |
| NCT07426848 | Not specified | RECRUITING | OT SMILE: Occupational Therapy Group Intervention for Primary Brain Tumour Patients |
| NCT00265174 | Not specified | UNKNOWN | Serum DNA Analysis: Potential Application for Diagnosis and Prognosis in Brain Cancer. |
| NCT00285324 | Not specified | COMPLETED | Diffusion Tensor MRI to Distinguish Brain Tumor Recurrence From Radiation Necrosis |
| NCT00595322 | Not specified | COMPLETED | Bevacizumab in the Radiation Treatment of Recurrent Malignant Glioma |
| NCT00629395 | Not specified | TERMINATED | Computerized Cognitive Training for Childhood Cancer Survivors |
| NCT00629447 | Not specified | COMPLETED | Innohep for Prophylaxis of Venous Thromboembolism in Brain Tumor Patients |
| NCT01779219 | Not specified | TERMINATED | Intraoperative MRI-guidance in Frameless Stereotactic Biopsies |
| NCT02167204 | Not specified | COMPLETED | 18F-FLT PET/CT in Measuring Cell Proliferation in Patients With Brain Tumors |
| NCT02272452 | Not specified | UNKNOWN | Assistance in Neurosurgery (ExtempoRMN) |
| NCT02389855 | Not specified | COMPLETED | Laser Ablation in Stereotactic Neurosurgery (LAISE): NeuroBlate® Retrospective Registry |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| FERUMOXYTOL | 4 | 2 |
| AMINOLEVULINIC ACID | 4 | 1 |
| ENTRECTINIB | 4 | 1 |
| ERIBULIN MESYLATE | 4 | 1 |
| LEVETIRACETAM | 4 | 1 |
| TINZAPARIN SODIUM | 4 | 1 |
| AVUTOMETINIB | 3 | 1 |
| ALOVUDINE F-18 | 2 | 1 |
| ETIRACETAM | 2 | 1 |
| FRESOLIMUMAB | 2 | 1 |
| GADOLINIUM | 2 | 1 |
| INDOXIMOD | 2 | 1 |
| 1-METHYLTRYPTOPHAN | 0 | 1 |
| LEVITIRACETAM | 0 | 1 |