Primary interstitial lung disease specific to childhood
diseaseOn this page
Also known as cHILDchildren's interstitial lung diseaseprimary ILD specific to childhood
Summary
Primary interstitial lung disease specific to childhood (MONDO:0017015) is a disease (an umbrella term covering 5 Mondo subtypes) and 228 clinical trials. Top therapeutic interventions include clemastine, thiamine ion, and brentuximab vedotin. A subtype of interstitial lung disease specific to childhood — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Umbrella term: 5 Mondo subtypes
- Clinical trials: 228
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | primary interstitial lung disease specific to childhood |
| Mondo ID | MONDO:0017015 |
| Orphanet | 264665 |
| ICD-11 | 1408868257 |
| UMLS | C3161253 |
| MedGen | 853969 |
| GARD | 0010559 |
| Is cancer (heuristic) | no |
Also known as: cHILD · children’s interstitial lung disease · primary ILD specific to childhood · primary interstitial lung disease specific to childhood
Disease family
This is a subtype of interstitial lung disease specific to childhood. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › lung disorder › interstitial lung disease › interstitial lung disease specific to childhood › primary interstitial lung disease specific to childhood
Related subtypes (4): Niemann-Pick disease type B, Hermansky-Pudlak syndrome with pulmonary fibrosis, familial hypocalciuric hypercalcemia, congenital emphysematous lung disease due to Filamin A loss-of-function variant
Subtypes (5): alveolar capillary dysplasia with misalignment of pulmonary veins, congenital chylothorax, lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome, interstitial lung disease specific to infancy, newborn respiratory distress syndrome
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 228.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 202 |
| PHASE4 | 13 |
| PHASE3 | 6 |
| PHASE2 | 5 |
| PHASE2/PHASE3 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04577690 | PHASE4 | RECRUITING | PECS Study for CIED Implantation Surgery |
| NCT06320626 | PHASE4 | RECRUITING | Pharmacokinetic-guided Dosing of Emicizumab |
| NCT00462371 | PHASE4 | COMPLETED | Comparison Between Insulin Pump Treatment and Multiple Daily Insulin Injections in Diabetic Type 1 Children |
| NCT01154595 | PHASE4 | COMPLETED | Effectiveness of a Ready-to-Use-Food (RUF) Supplement to Prevent Acute Child Malnutrition |
| NCT01204411 | PHASE4 | WITHDRAWN | Efficacy of Artesunate-amodiaquine (AS-AQ) in Children With Malaria and Severe Acute Malnutrition, Madaoua, Niger 2010 |
| NCT02248493 | PHASE4 | COMPLETED | Intravenous Paracetamol for Postoperative Pain |
| NCT02300701 | PHASE4 | COMPLETED | Role of Anti-IgE in Severe Childhood Eczema |
| NCT02464865 | PHASE4 | COMPLETED | Thiamin Deficiency in Obese Thai Children |
| NCT02738814 | PHASE4 | UNKNOWN | Propofol for Treatment on Emergence Agitation |
| NCT02985177 | PHASE4 | WITHDRAWN | A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture |
| NCT03426462 | PHASE4 | COMPLETED | Time to Peak Effect of Propofol in Children |
| NCT05515887 | PHASE4 | COMPLETED | Influence of Shenqu Xiaoshi Oral Liquid on Intestinal Microbiome of Children With Functional Dyspepsia |
| NCT06037915 | PHASE4 | COMPLETED | Airway Interventions During Intravenous Anesthesia in Children Undergoing Direct Laryngoscopy for Surgical Procedures Using High Flow Nasal Versus Low Flow Oxygen. A Pilot Study.(Flowkid) |
| NCT06563245 | PHASE2/PHASE3 | RECRUITING | Brentuximab Vedotin for Newly Diagnosed cHL in Chinese CAYA Based on PET/CT Assessment |
| NCT07336095 | PHASE3 | NOT_YET_RECRUITING | Melatonin vs Midazolam in Children Undergoing Tonsillectomy |
| NCT00408135 | PHASE3 | COMPLETED | Japanese Study Evaluating Safety, Efficacy and Acceptability of Telithromycin in Children With Infections |
| NCT01122927 | PHASE3 | TERMINATED | Safety and Tolerability of Aripiprazole in Adolescents With Schizophrenia or Children and Adolescents With Bipolar I Disorder, Manic or Mixed Episode With or Without Psychotic Features. |
| NCT01552642 | PHASE3 | COMPLETED | An Interactive Web-based Intervention to Achieve Healthy Weight in Young Children |
| NCT02338440 | PHASE2/PHASE3 | UNKNOWN | Pharmacokinetic Study of Lipo-PGE1 for Prevention of VOD After HSCT |
| NCT02348073 | PHASE3 | COMPLETED | Efficacy of Phosphatidylserine Enriched With n-3 PUFA Supplementation on ADHD in Children With Epilepsy |
| NCT05799053 | PHASE3 | COMPLETED | Peppermint Oil for the Treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT Study |
| NCT05999994 | PHASE2 | RECRUITING | A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer |
| NCT02339350 | PHASE2 | UNKNOWN | Treatment of Newly Diagnosed High Risk Acute Lymphoblastic Leukemia in Children |
| NCT03741101 | PHASE2 | UNKNOWN | Treatment of NF1-related Plexiform Neurofibroma With Trametinib |
| NCT06164600 | PHASE2 | COMPLETED | Bovine Colostrum for Prophylaxis Against Recurrent Urinary Tract Infection in Children |
| NCT06315699 | PHASE2 | COMPLETED | Clemastine Fumarate in the Treatment of Neurodevelopmental Delays in Williams Syndrome |
| NCT02852928 | Not specified | RECRUITING | European Management Platform for Childhood Interstitial Lung Diseases - chILD-EU Register and Biobank |
| NCT03426579 | Not specified | RECRUITING | Correlation Between Sedation Depth Monitoring and Reflexes During Intravenous Anesthesia With Dexmedetomidine and Remifentanil in Children Undergoing Direct Laryngoscopy for Surgical Procedures |
| NCT04022460 | Not specified | ACTIVE_NOT_RECRUITING | Using Personal Mobile Technology to Identify Obstructive Sleep Apnea in Children With Down Syndrome (UPLOAD) |
| NCT04528810 | Not specified | NOT_YET_RECRUITING | A Study of Child Injury Based on Data Mining |
| NCT04989790 | Not specified | RECRUITING | Clinical Effectiveness of the PICU Up! Multifaceted Early Mobility Intervention for Critically Ill Children |
| NCT05016271 | Not specified | ACTIVE_NOT_RECRUITING | Health Benefits of Air Purifiers in Primary School Students |
| NCT05615324 | Not specified | ACTIVE_NOT_RECRUITING | SAFIR Family Talk - Investigating the Effect of The Family Talk Intervention |
| NCT05790785 | Not specified | RECRUITING | Vascular Complications in Children From T1D Diagnosis |
| NCT05849753 | Not specified | RECRUITING | Breaking Disparities in Access to Advanced Diabetes Technologies in Children With Type 1 Diabetes |
| NCT05914324 | Not specified | ACTIVE_NOT_RECRUITING | Outpatient Pediatric Pulse Oximeters in Africa |
| NCT06047821 | Not specified | ACTIVE_NOT_RECRUITING | Enterics for Global Health (EFGH) |
| NCT06092671 | Not specified | RECRUITING | Effect of FPCA on Incidence of Emergency Delirium in Children After Surgery |
| NCT06312410 | Not specified | RECRUITING | The VIA Family 2.0 - a Family Based Intervention for Families with Parental Mental Illness |
| NCT06400667 | Not specified | ACTIVE_NOT_RECRUITING | Functional Assessment Protocol for the Upper Limb for Pediatric Age |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CLEMASTINE | 4 | 3 |
| THIAMINE ION | 4 | 2 |
| BRENTUXIMAB VEDOTIN | 4 | 1 |
| DACARBAZINE | 4 | 1 |
| HYDROCODONE | 4 | 1 |
| IBUPROFEN | 4 | 1 |
| KETOPROFEN | 4 | 1 |
| MORPHINE | 4 | 1 |
| OMALIZUMAB | 4 | 1 |
| TELITHROMYCIN | 4 | 1 |
| TISLELIZUMAB | 4 | 1 |
| TRAMADOL | 4 | 1 |
| TRAMETINIB | 4 | 1 |
| WATER | 4 | 1 |
| PEPPERMINT | 3 | 1 |
| STARCH, CORN | 3 | 1 |
| CHEMBL4059722 | 0 | 1 |
| CHEMBL4589226 | 0 | 1 |
| CHEMBL5592090 | 0 | 1 |
| CHEMBL1215848 | 0 | 1 |
| CHEMBL1574179 | 0 | 1 |
| CHEMBL5433950 | 0 | 1 |
| (R,R)-TRAMADOL | 0 | 1 |